Use of algorithm of the prevention complex of inflammatory processes in the oral cavity in metabolic syndrome




metabolic syndrome, treatment-and-prophylactic complex, inflammation, cytokine status, periodontal tissues


The aim of the work was to evaluate in the experiment the effectiveness of the developed treatment-and-prophylactic complex for the prevention of periodontal tissue disorders under metabolic syndrome simulation.

Materials and methods: The study of biochemical and immunological changes in the blood serum, liver and gingival tissue was performed during simulation on the metabolic syndrome of alimentary genesis on Wistar rats, all animals were divided into 5 groups: 1) intact, 2) with simulated metabolic syndrome, 3) in a week after the start of MS simulation 5 times a week in the morning perorally administered a “Capillaroprotect” aqueous solution (bioflavonoid, antioxidant) produced by “Ekosvit Oil” (Ukraine) at a rate of 135 mg/kg, 4) under similar conditions receiving the preparation based on the dihydroquercetin were locally applied on gums a new dental elixir based on bee products and adaptogens of plant origin by o,5 ml/rat with a tampon, which has held for 5–7 minutes, 5) during MS simulation from the second week were used the preparation based on the dihydroquercetin, the dental elixir topically on gums and physiotherapy.

Results: Under conditions of experimental MS simulation with a diet rich in saturated fats and carbohydrate there are systemic disorders in the body: reduced nonspecific antimicrobial protection, increased microbial contamination, intensification of lipid peroxidation, the development of inflammation and hepatotoxicity. Prophylactic administration of the proposed dihydroquercetin preparation to animals in the process of simulation of MS significantly inhibits the established disorders, positively affecting the biochemical parameters of the blood serum, liver tissue, periodontium, reducing triglycerides, total cholesterol, glucose level, restoring the state of non-specific resistance, lipid metabolism, preventing inflammation and hepatosis, as well as contamination with pathogenic microflora.

Conclusion. The proposed treatment-and-prophylactic complex, which includes the dihydroquercetin preparation, used per os in combination with local therapy of periodontal tissues with a tooth elixir based on propolis and biologically active substances of plant origin adaptogens with ultraphonophoresis under induced metabolic syndrome significantly removed the negative effects of its most important components

Author Biographies

Lyudmila Kravchenko, Odessa National Medical University

Doctor of Medical Science, Professor

Department of Therapeutic Dentistry

Olen Appelhans, Odessa National Medical University

Doctor of Medical Science, Professor

Department of Normal and Pathological Clinical Anatomy

Anatoliy Poliakov, Odessa National Medical University

Department of Internal Medicine No. 3

Liana Unhurian, Odessa National Medical University

Doctor of Pharmacy Sciences, Professor

Department of Organization and Economics of Pharmacy

Oleksandr Pasechnyk, Odessa National Medical University

PhD, Associate professor

Department of Surgical dentistry

Mariya Rozumenko, Odessa National Medical University


Department of Orthopedic Dentistry

Yana Ivanova, Odessa National Medical University


Department of Internal Medicine No. 3

Vladislav Rozumenko, Odessa National Medical University


Department of Orthopedic Dentistry


  1. Saklayen, M. G. (2018). The Global Epidemic of the Metabolic Syndrome. Current Hypertension Reports, 20 (2). doi:
  2. Jaramillo, A., Contreras, A., Lafaurie, G. I., Duque, A., Ardila, C. M., Duarte, S., Osorio, L. (2016). Association of metabolic syndrome and chronic periodontitis in Colombians. Clinical Oral Investigations, 21 (5), 1537–1544. doi:
  3. Hrygorieva, O. A., & Korotchuk, Y. V. (2020). Morphometric, instrumental and laboratory parameters of female rats with experimental metabolic syndrome. Achievements of Clinical and Experimental Medicine, 3, 20–25. doi:
  4. Petrukhina, N. B., Shikh, E. V., Zorina, O. A., Kartysheva, E. V. (2018). Medikamentoznaia terapiia khronicheskogo generalizovannogo parodontita u patcientov s metabolicheskim sindromom. Stomatologiia, 6 (2), 45–46.
  5. Kravchenko, L., Appelhans, O., Poliakov, A., Unhurian, L., Ivchenko, N., Bas, N. et. al. (2021). Topical application of the new dental elixir for treatment of periodontal complications during experimental reproduction of the metabolic syndrome. Pharmacology online, 3, 1–9.
  6. Gosteva, Z. V. (2016). Aktualnist kompleksnoho likuvannia khvorykh iz zakhvoriuvanniamy parodonta na tli metabolichnoho syndromu. Problemy osteolohii, 1, 51–56.
  7. Reshetniak, M. V., Khirmanov, V. N., Zybina, N. N. (2011). Model metabolicheskogo sindroma, vyzvannaia kormleniem fruktozoi: patogeneticheskie vzaimosviazi obmennykh narushenii. Meditcinski akademicheskii zhurnal, 11 (3), 23–27.
  8. Birulina, J. G., Ivanov, V. V., Buyko, E. E., Bykov, V. V., Smagliy, L. V., Nosarev, A. V. et. al. (2021). High-fat, high-carbohydrate diet-induced experimental model of metabolic syndrome in rats. Bulletin of Siberian Medicine, 19 (4), 14–20. doi:
  9. Makarova, M. N., Makarov, V. G. (2018). Diet-Induced Models Of Metabolic Disorders. Experimental Metabolic Syndrome. Laboratory Animals for Science, 1 (1), 79–91. doi:
  10. Kravchenko, L. S., Appelkhans, O. L., Ivanova, Ya. I., Goncharenko, O. V. (2021). Pat. No. 122996 UA. Zubnyi eliksyr dlia mistsevoi profilaktyky i likuvannia zapalnykh protsesiv slyzovoi obolonky porozhnyny rota ta tkanyn parodonta. MPK (2021.01) А61К8/19, А61К35/644. No. а202002339. declareted: of 10.04.2020; published: 27.01.2021, Bul. No.4.
  11. Goriachkovskii, A. M. (2003). Klinicheskaia biokhimiia v laboratornoi diagnostike. Odesa: Ekologiia, 616.
  12. Levitckii, A. P., Denga, O. V., Makarenko, O. A. et. al. (2010). Biokhimicheskie markery vospaleniia tkanei rotovoi polosti. Odesa: KPOGT, 16.
  13. Petrukhina, N. B., Zorina, O. A., Shikh, E. V., Kartysheva, E. V., Kudryavtsev, A. V., Berkutova, I. S. (2018). Changes in proinflammatory cytokines in patients with chronic periodontitis and metabolic syndrome, depending on gender and age. Stomatologiya, 97 (6), 38–45. doi:
  14. Gustavo, P., Andreza, M. F., Elcia, M., Espindola, A., Celso, M., Mila, F. M. et. al. (2012). The Role of Chemokines and Cytokines in the Pathogenesis of Periodontal and Periapical Lesions: Current Concepts. Inflammation, Chronic Diseases and Cancer – Cell and Molecular Biology, Immunology and Clinical Bases. InTech. doi:
  15. Mirhafez, S. R., Pasdar, A., Avan, A., Esmaily, H., Moezzi, A., Mohebati, M. et. al. (2015). Cytokine and growth factor profiling in patients with the metabolic syndrome. British Journal of Nutrition, 113 (12), 1911–1919. doi:
  16. Shnaider, S. A., Levitckii, A. P. (2017). Eksperimentalnaia stomatologiia. Chast 1: eksperimentalnye modeli stomatologicheskikh zabolevani. Odessa: KP “OGT”, 167.
  17. Obergan, T. Y., Grigorjeva, M. E. (2016). Evaluation of hemostasis, lipid and carbohydrate metabolism parameters in rats with modified model of experimental metabolic syndrome. Sovremennye tehnologii v medicine, 8 (4), 303–305.
  18. Pyndus, T. A., Denga, A. E., Tkachenko, E. K. (2017). State of oral cavity tissues of rats in conditions of modeling metabolic syndrome. Bukovinian Medical Herald, 21 (4 (84)), 89–98. doi:
  19. Shalitin, S., Battelino, T., Moreno, L. A.; Koletzko, B., Shamir, R., Turck, D., Phillip, M. (Eds.) (2019). Obesity, metabolic syndrome and nutrition. Nutrition and growth. World Review of Nutrition and Dietetics. Basel: Karger, 119, 13–42. doi:
  20. Meladze, I. N. (2016). Vospalitelno-destruktivnye izmeneniia v tkaniakh parodonta krys pri eksperimentalnom metabolicheskom sindrome i puti ikh ustraneniia. Sovremennaia stomatologiia, 4, 73–75.




How to Cite

Kravchenko, L., Appelhans, O., Poliakov, A., Unhurian, L., Pasechnyk, O., Rozumenko, M., Ivanova, Y., & Rozumenko, V. (2022). Use of algorithm of the prevention complex of inflammatory processes in the oral cavity in metabolic syndrome. ScienceRise: Pharmaceutical Science, (4 (38), 62–68.



Pharmaceutical Science