Determination of standardization parameters of Oxycoccus macrocarpus (Ait.) Pursh and Oxycoccus palustris Pers. Leaves




large cranberry, common cranberry, leaves, morphological and anatomical features, standardization


 The aim. Extracts of cranberry large leaves have prospects when used to correct insulin-resistant conditions. There­fore, to create new drugs based on cranberry leaves, you need to develop instructions for cultivating the plant, harvesting raw materials and methods of quality control. Therefore, the aim of the research was to determine the pa­rameters of standardization of large cranberry leaves (Oxycoccus macrocarpus (Ait.) Pursh) and swamp cranberries (Oxycoccus palustris Pers.).

Materials and methods. Macro- and microscopic studies of raw materials were performed according to the method of SPhU 2.8.23 “Microscopic examination of medicinal plant raw materials”. Macroscopic examinations were per­formed using a magnifying glass and MBS-9 binocular microscope. Identification of basic substances was performed by TLC, testing and quantification of flavonoids according to SPhU methods.

Results. The morphological and anatomical features of the leaves of common cranberry and large cranberry were determined. The general features of the structure of stems and leaves species and different differences for each species are were revealed. TLC identification of the main BAS of raw materials was developed and standardization parameters were determined.

Conclusions. The parameters of cranberry leaf standardization are determined by the following indicators: mac­ro-and microscopic features, TLC identification of the main BAS raw materials (hyperoside, rutin and caffeic acid), impurities (not more than 2 %), brown stems not more than 5 %, weight loss during drying (not more than 10 %), total ash (not more than 7 %) and not less than 1 % of flavonoids, in terms of hyperoside

Supporting Agency

  • This work was supported by the Ministry of Health Care of Ukraine from the State Budget in the framework [grant number 2301020] “Scientific and scientific‐technical activity in the field of health protection” on the topic “Modern approaches to the creation of new medicines for a correction of metabolic syndrome”.

Author Biographies

Inna Vlasova, National University of Pharmacy

Postgraduate Student

Department of Pharmacognosy

Tetiana Gontova, National University of Pharmacy

Doctor of Pharmaceutical Sciences, Professor

Department of Pharmacognosy

Lyubov Grytsyk, Ivano-Frankivsk National Medical University

PhD, Associate Professor

Department of Chemistry, Pharmaceutical Analysis and Postgraduate Education

Gulsim Zhumashova, Asfendiyarov Kazakh National Medical University

PhD, Head of Department

Department of Pharmaceutical and Toxicological Chemistry, Pharmacognosy and Botany

Galiya Sayakova, Asfendiyarov Kazakh National Medical University

PhD, Professor

Department of Pharmaceutical and Toxicological Chemistry, Pharmacognosy and Botany

Assyl Boshkayeva, Asfendiyarov Kazakh National Medical University

Doctor of Pharmaceutical Sciences, Associate Professor

Department of Pharmaceutical and Toxicological Chemistry, Pharmacognosy and Botany

Mariia Shanaida, Ivan Horbachevsky Ternopil National Medical University of the Ministry of Health of Ukraine

Doctor of Pharmaceutical Sciences, Associate Professor

Department of Pharmacognosy and Medical Botany

Oleh Koshovyi, National University of Pharmacy

Doctor of Pharmaceutical Sciences, Professor

Department of Pharmacognosy


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How to Cite

Vlasova, I., Gontova, T., Grytsyk, L., Zhumashova, G., Sayakova, G., Boshkayeva, A., Shanaida, M., & Koshovyi, O. (2022). Determination of standardization parameters of Oxycoccus macrocarpus (Ait.) Pursh and Oxycoccus palustris Pers. Leaves. ScienceRise: Pharmaceutical Science, (3(37), 48–57.



Pharmaceutical Science