Macroscopic and microscopic analysis of Alfredia nivea KAR. & KIR herb




Alfredia nivea, medicinal plant raw material, morphological and anatomical signs, standardization


Kazakhstan flora is rich in promising little-studied plants that are used in folk medicine, but additional deep research is required for their introduction into medical practice with the help of modern scientific techniques. An interesting object for introduction into the official medical and pharmaceutical practice is the Alfredia Nivea Kar. & Kir, family Asteraceae, whose extracts have a neurotropic effect.

The aim. Regarding mentioned above, in order to create new medicines based on the grass of the Alfredia nivea, it is necessary to develop methods of its macro and microscopic identification.

Materials and methods. Macro- and microscopic studies of the grass of Alfredia nivea were carried out in accordance with the methodology of SPhU 2.8.23 "Microscopic examination of medicinal vegetable raw materials". Macroscopic studies were performed using magnifying glass and binocular microscope MBS-9, microscopic-using MS Microscopes 10 (eyepiece X5, X10, X15, lenses x10, x40), micromed XS-4130 (WF15X, Opera, lens X40/0, 65, x10/0,25) with microphoto addon (China).

Results. The morphological and anatomical features of the Alfredia nivea grass. Diagnostic features of the structure of stems, leaves and flowers of this species were revealed.

Conclusions. The macroscopic and anatomical identification parameters of the grass of the Alfredia of Snow. The study of the morphological and anatomical features of the stems, leaves and flowers of Alfredia nivea, considering the requirements of European pharmacopoeia. Diagnostic features of the structure of stems, leaves and flowers of the species were found, which were used as key quality indicators for standardization and identification of raw materials

Author Biographies

Almat Rustemkulov, S. D. Asfendiyarov Kazakh National Medical University

PhD Student

Tetiana Gontova, National University of Pharmacy

Doctor of Pharmaceutical Sciences, Professor

Department of Pharmacognosy

Balzhan Makhatova, S. D. Asfendiyarov Kazakh National Medical University

PhD, Associate Professor

Department of Engineering Disciplines and Good Practices

Aisana Rustemkulova, S. D. Asfendiyarov Kazakh National Medical University

PhD Student

Nadezhda Gemedzhieva, Institute of Botany and Phytointroduction

Doctor of Biological Sciences, Head of Laboratory

Laboratory of Plant Resources

Aizhamal Shormanova, Institute of Botany and Phytointroduction

PhD, Leading Specialist

Laboratory of Flora of Higher Plants

Galyna Starchenko, Ivano-Frankivsk National Medical University

PhD, Associate Professor

Department of Pharmaceutical Management, Drug Technology and Pharmacognosy

Ain Raal, University of Tartu

PhD, Professor

Institute of Pharmacy

Ubaidilla Datkhaev, S. D. Asfendiyarov Kazakh National Medical University

Doctor of Pharmaceutical Sciences, Professor, Vice-Rector for Corporate Development

Oleh Koshovyi, National University of Pharmacy

Doctor of Pharmaceutical Sciences, Professor

Department of Pharmacognosy


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How to Cite

Rustemkulov, A., Gontova, T., Makhatova, B., Rustemkulova, A., Gemedzhieva, N., Shormanova, A., Starchenko, G., Raal, A., Datkhaev, U., & Koshovyi, O. (2023). Macroscopic and microscopic analysis of Alfredia nivea KAR. & KIR herb. ScienceRise: Pharmaceutical Science, (1(41), 41–49.



Pharmaceutical Science