Extracts of the Canadian goldenrod (Solidago Canadensis L.) – promising agents with antimicrobial, anti-inflammatory and hepatoprotective activity

Yurii Hrytsyk; Oleh Koshovyi; Roman Hrytsyk; Ain Raal

doi:10.15587/2519-4852.2024.310837

Authors

Yurii Hrytsyk Ivano-Frankivsk National Medical University, Ukraine https://orcid.org/0000-0003-3006-290X
Oleh Koshovyi National University of Pharmacy, Ukraine https://orcid.org/0000-0001-9545-8548
Roman Hrytsyk Ivano-Frankivsk National Medical University, Ukraine https://orcid.org/0000-0003-3592-2606
Ain Raal University of Tartu, Estonia https://orcid.org/0000-0001-8731-7366

DOI:

https://doi.org/10.15587/2519-4852.2024.310837

Keywords:

Canadian goldenrod (Solidago L.), extract, phenolic compounds, antimicrobial activity, anti-inflammatory activity, hepatoprotective activity

Abstract

S. canadensis L. and S. virgaurea L. are the most common species of Solidago L. in Europe and with a long tradition of use in medicine for various therapeutic purposes: diseases of the urinary tract, gastrointestinal tract, diabetes, allergies and antiseptic purposes. Therefore, the research of species of the Solidago genus, which have a rich content of natural BACs, and the development of new effective medicinal products of plant origin are relevant.

The aim. The method of work is the phytochemical and pharmacological study of extracts of the Canadian goldenrod herb, obtained by ethanol solutions of various concentrations, for the innovative perspective of creating new medicines based on them with antimicrobial, anti-inflammatory and hepatoprotective activity.

Materials and methods. The objects of the study were extracts of herb from Canadian goldenrod, obtained using purified water, 40 %, 70 % and 90 % ethanol. Phytochemical study of the extracts was performed by TLC and spectrophotometry. Study of acute toxicity, antimicrobial, anti-inflammatory and hepatoprotective activity of extracts was carried out according to standard methods.

Research results. A study of the phytochemical composition and pharmacological activity of extracts of herb from Canadian goldenrod obtained with different solvents. It was established that extracts of herb from Canadian goldenrod show anti-inflammatory activity. The most pronounced antiexudative activity is shown by the extract of the Canadian goldenrod herb (extractant - 40 % ethanol), reducing the degree of swelling by 24.77 %. Herb extracts from from Canadian goldenrod in acute toxic liver damage show moderate hepatoprotective activity, which is somewhat inferior to the comparative drug "Silibor". A more intense and effective effect on the hepatobiliary system was shown by the extract of the Canadian goldenrod herb (extractant - 40 % ethanol).

Conclusions. The perspective of creation based on herb of Canadian goldenrod new drugs with hepatoprotective activity. The most promising substance turned out to be an extract of herb from Canadian goldenrod obtained with a 40 % ethanol solution.

Author Biographies

Yurii Hrytsyk, Ivano-Frankivsk National Medical University

PhD Student

Department of Pharmaceutical Management, Drugs Technology and Pharmacognosy

Oleh Koshovyi, National University of Pharmacy

Doctor of Pharmaceutical Sciences, Professor

Department of Pharmacognosy and Nutriciology

Roman Hrytsyk, Ivano-Frankivsk National Medical University

PhD, Assistant

Department of Oncology

Ain Raal, University of Tartu

PhD, Professor

Institute of Pharmacy

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