Selection of the base for a topical pharmaceutical form for stump care after prosthetic fitting

Authors

DOI:

https://doi.org/10.15587/2519-4852.2024.313142

Keywords:

amputation, prosthetics, complications, therapy, prevention, semi-solid medicine, technology, structural and mechanical properties

Abstract

The aim of the work. Rehabilitation of patients with amputation of the lower limbs is an urgent task of society. Currently, the pharmaceutical market of Ukraine lacks medicinal products for stump care of domestic production. Therefore, the aim of this work was to research the selection of the basis of soft medicine for the care of stumps after prosthetics.

Materials and methods. The objects of the study were samples of a soft medicinal product on an emulsion basis. Gelling agents (aristoflex, xanthan gum, aerosil) were used as regulators of the structural and mechanical parameters of soft medicine. Research was conducted using a set of studies to determine organoleptic and structural-mechanical indicators.

Results. According to the results of the organoleptic analysis, according to the indicators of homogeneity, the presence of delamination, samples were selected for further research, where aristoflex and xanthan gum were used as a thickener. According to the results of structural and mechanical studies, it was established that the samples with xanthan gum have a satisfactory degree of spreading and adhesiveness, which increases with increasing exposure to mechanical forces. The determined values ​​of static and dynamic coefficients of friction testify to the sliding properties of samples with xanthan gum.

Conclusion. It was established that the addition of xanthan gum to the composition of the base would provide all the necessary characteristics for a soft medicine that is planned to be used in the care of the stump after prosthetics

Supporting Agency

  • State budget of Ukraine within the framework of the budget program KPKVK2301020 "Research, scientific and scientific and technical developments, implementation of works under state target programs and state orders, training and advanced training of scientific personnel in the field of health care, financial support for the development of scientific infrastructure and objects constituting the national heritage" related to the topic 0124U001991 "Development of soft drugs to improve the functional state of the stump during prosthetics".

Author Biographies

Inna Kovalevska, National University of Pharmacy

Doctor of Pharmaceutical Sciences, Professor

Department of Industrial Technology of Medicines and Cosmetics

Halyna Slipchenko, National University of Pharmacy

Doctor of Pharmaceutical Sciences, Professor

Department of Industrial Technology of Medicines and Cosmetics

Yuliia Maslii, Lithuanian University of Health Sciences

PhD, Researcher

Department of Drug Technology and Social Pharmacy

Nataliia Herbina, Lithuanian University of Health Sciences

Junior Researcher

Department of Drug Technology and Social Pharmacy

Olena Ruban, National University of Pharmacy

Doctor of Pharmaceutical Sciences, Professor, Head of Department

Department of Industrial Technology of Medicines and Cosmetics

Olena Ivaniuk, National University of Pharmacy

PhD, Assistant

Department of Drug Technology

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Selection of the base for a topical pharmaceutical form for stump care after prosthetic fitting

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Published

2024-10-31

How to Cite

Kovalevska, I., Slipchenko, H., Maslii, Y., Herbina, N., Ruban, O., & Ivaniuk, O. (2024). Selection of the base for a topical pharmaceutical form for stump care after prosthetic fitting. ScienceRise: Pharmaceutical Science, (5 (51), 71–77. https://doi.org/10.15587/2519-4852.2024.313142

Issue

No. 5 (51) (2024)

Section

Pharmaceutical Science

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Copyright (c) 2024 Inna Kovalevska, Halyna Slipchenko, Yuliia Maslii, Nataliia Herbina, Olena Ruban, Olena Ivaniuk

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