Effects of noni leaf extract (Morinda citrifolia L.) on the histopathological appearance of mouse aorta

Authors

DOI:

https://doi.org/10.15587/2519-4852.2025.336968

Keywords:

Atherosclerosis, Histopathological Findings of Mouse Aorta, Hypercholesterolemia, and Noni Leaf Extract

Abstract

Hypercholesterolemia is a metabolic disorder that can lead to the formation of atherosclerotic plaques. One method to manage atherosclerosis is by lowering cholesterol levels. Cholesterol reduction can be achieved through the use of medications or medicinal plants. One of the plants that can be used to lower levels is the noni leaf (Morinda citrifolia L.).

The aim. The aim of this study is to investigate the histopathological changes in the aorta of mice after treatment with noni leaf extract.

Materian and methods. This study was conducted using 25 male mice aged 2-2.5 months with a body weight of 25-30 grams, divided into 5 treatment groups, each consisting of 5 mice. The first group was left untreated as the normal control (KN). The second group was given 0.5% CMC-Na at a dose of 0.28 ml/20 g body weight as the negative control (K(-)). The third group received simvastatin at a dose of 0.026 mg/20 g body weight as the positive control (K(+)). The fourth (P1) and fifth (P2) groups were administered noni leaf extract at doses of 5.6 mg/20 g body weight and 11.2 mg/20 g body weight, respectively.

Result. The results of the study indicate that the histopathological findings of the mouse aorta in each treatment group are consistent with the average damage scores obtained for each group. The histopathological findings of the aorta in the normal control, negative control, positive control, extract dose 1, and extract dose 2 groups showed average damage scores of 0.00, 0.20, 1.40, 0.53, and 0.27, respectively.

Conclusion. It can be concluded that the noni leaf extract at doses of 5.6 mg/20 g body weight and 11.2 mg/20 g body weight can improve, reduce, and diminish the histopathological damage to the mouse aorta, although not as effectively as simvastatin at 0.026 mg/20 g body weight

Supporting Agency

  • This study was funded by the Faculty of Teacher Training and Education, Tanjungpura University through the Merdeka Belajar Kampus Merdeka (MBKM) program.

Author Biographies

Ruqiah Ganda Putri Panjaitan, Tanjungpura University

Professor, Doctor, Master of Science, Bachelor of Science

Department of Biology Education

Andi Besse Tenriawaru, Tanjungpura University

Master of Pedagogy, Bachelor of Education

Department of Biology Education

Nurul Hayati, Tanjungpura University

Bachelor of Education

Department of Biology Education

Hurriah Dewi Sartika Panjaitan, Basuki Rahmat Primary Health Care Center

Medical doctor

Dona Fitriawan, Tanjungpura University

Master of Pedagogy, Bachelor of Education

Department of Mathematics Education

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Effects of noni leaf extract (Morinda citrifolia L.) on the histopathological appearance of mouse aorta

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Published

2025-12-30

How to Cite

Panjaitan, R. G. P., Tenriawaru, A. B., Hayati, N., Panjaitan, H. D. S., & Fitriawan, D. (2025). Effects of noni leaf extract (Morinda citrifolia L.) on the histopathological appearance of mouse aorta. ScienceRise: Pharmaceutical Science, (6 (58), 45–51. https://doi.org/10.15587/2519-4852.2025.336968

Issue

No. 6 (58) (2025)

Section

Pharmaceutical Science

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Copyright (c) 2025 Ruqiah Ganda Putri Panjaitan, Andi Besse Tenriawaru, Nurul Hayati, Hurriah Dewi Sartika Panjaitan, Dona Fitriawan

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