Rheological characteristics of hydroxyethylcellulose -based gels

Authors

  • Ігор Віталійович Улізко Odessa National Medical University Valihovskyy lane, 2, Odesa, Ukraine, 65082, Ukraine
  • Віктор Васильович Трохимчук Shupyk National Medical Academy of Postgraduate Education Dorogozhytska str., 9, Kyiv, Ukraine, 04112, Ukraine
  • Владислав Іванович Чуєшов National University of Pharmacy Pushkinskaya str., 53, Kharkiv, Ukraine, 61002, Ukraine

DOI:

https://doi.org/10.15587/2519-4852.2016.81353

Keywords:

gel, hydroxymethyl cellulose, structural and mechanical properties, rheology, mechanical strength, viscosity, yield value, shear rate, thyxotropic properties

Abstract

Aim. Study of structural and mechanical properties of gel bases with hydroxyethylcellulose (HEC) for further development of anti-inflammatory action gel.

Methods. Pharmaco-technological, physical-chemical and structural-mechanical methods of study have been used.

Structural and mechanical properties of the developed gel have been studied using rotational viscometer «Rheolab QC» («Anton Paar», Austria) with coaxial cylinders CC27/S-SN29766.

Results. Optimum concentration of hydroxyethylcellulose has been determined as 2 %, that provides the required structural-mechanical properties of gel base. It has been determined that gel base with hydroxyethylcellulose belongs to Newtonian flow type with plastic properties and has thyxotropic properties.

The calculated mechanical strength value of the studied gel base is from 1,07 to 1,28 that allows forecasting the drug’s stability in production and storage. The obtained data will be used in development of anti-inflammatory action gel.

Conclusion. Optimum composition of gel base with hydroxyethylcellulose for development of anti-inflammatory action gel

Author Biographies

Ігор Віталійович Улізко, Odessa National Medical University Valihovskyy lane, 2, Odesa, Ukraine, 65082

Assistant

Department of Pharmaceutical Chemistry and Drug Technology

Віктор Васильович Трохимчук, Shupyk National Medical Academy of Postgraduate Education Dorogozhytska str., 9, Kyiv, Ukraine, 04112

Doctor of Pharmacy, Professor

Department of organization and economics of pharmacy

Владислав Іванович Чуєшов, National University of Pharmacy Pushkinskaya str., 53, Kharkiv, Ukraine, 61002

Doctor of Pharmacy, Professor

Department of Industrial Pharmacy

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Published

2016-10-30

How to Cite

Улізко, І. В., Трохимчук, В. В., & Чуєшов, В. І. (2016). Rheological characteristics of hydroxyethylcellulose -based gels. ScienceRise: Pharmaceutical Science, (3 (3), 44–48. https://doi.org/10.15587/2519-4852.2016.81353

Issue

No. 3 (3) (2016)

Section

Pharmaceutical Science

License

Copyright (c) 2016 Ігор Віталійович Улізко, Віктор Васильович Трохимчук, Владислав Іванович Чуєшов

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