Enhanced recovery after surgery for bladder cancer patients after radical cystectomy with ileal neobladder

Authors

  • О.E. Stakhovskyi National Cancer Institute, Ukraine

DOI:

https://doi.org/10.26641/2307-5279.23.1.2019.161664

Keywords:

bladder cancer, multimodal fast recovery program, fast track

Abstract

Objective. Study of the Enhanced recovery after surgery (ERAS) protocol in patients with urinary bladder cancer after cystectomy with neobladder. Маterials and methods. Retrospective analysis of the use of ERAS in patients with bladder cancer after radical cystectomy compared with standard postoperative approach. The study group included 21 patients, during which ERAS protocol was used. The control group consisted of 43 matched patients with similar clinical characteristics, which were treated before the implementation of study protocol. The comparative analysis of parameters in study and control groups was carried out using the “hi-square” method. Tо evaluatу efficacy of study protocol intra- and postoperative complications were analyzed. Analysis of the the duration of stay in the hospital, the intensity of pain manifestations on the 10-point visual-analog scale for 3 days after the operation, and the level of readmition in 30 days after the operation. Results. There was a significant difference in the rate of postoperative stay of patients in the hospital among the study groups. In the ERAS protocol group this parameter was 9.2 ± 2. 1 and a for the controln group 13.4 ± 3.1 days (p <0.01). The pain intensity scores were lower in the study group (3.6 ± 1.2 points) versus (5.1 ± 1.3 points) control group (p <0.05). This can be explained by the use of prolonged epidural anesthesia in the postoperative period, smaller incisions for access and the presence of fewer postoperative drainages. Conclusion. The presented results of the study indicate the promising use ERAS protocol in the treatment of patients with invasive urinary carcinoma, that underwent radical cystectomy with ileal neobladder. Such approach reduces the intensity of pain in the postoperative period and decrease the duration of postoperative stay in hospital.

References

White PF, Kehlet H, Neal JM, Schricker T, Carr D, Carli F. The role of the anesthesiologist in fast-track surgery: from multimodal analgesia to perioperative medical care. Anesth. Analg – 2007 – V. 104. – P. 1380–1396. DOI: 10.1213/01.ane.0000263034.96885.e1.

Park JC, Gandhi NM, Carducci MA, Eisenberger MA, Baras AS, Netto GJ, et al. A Retrospective Analysis of the Effect on Survival of Time from Diagnosis to Neoadjuvant Chemotherapy to Cystectomy for Muscle Invasive Bladder Cancer. J Urol. 2016 Apr;195(4P1):880–5. DOI:10.1016/j.juro.2015.11.024.

Lawrentschuk N, Colombo R, Hakenberg OW, Lerner SP, Mеnsson W, Sagalowsky A, et al. Prevention and management of complications following radical cystectomy for bladder cancer. Eur Urol. 2010 Jun;57(6):983–1001. DOI: 10.1016/j.eururo.2010.02.024.

Kehlet H. Fast-track colorectal surgery. Lancet. 2008 Mar 8;371(9615):791–3. DOI: 10.1016/S0140-6736(08)60357-8.

Tabibi A, Simforoosh N, Basiri A, Ezzatnejad M, Abdi H, Farrokhi F., et al Bowel preparation versus no preparation before ileal urinary diversion. Urology. 2007 Oct;70(4):654–8. DOI: 10.1016/j.urology.2007.06.1107.

Xu R, Zhao X, Zhong Z, Zhang L. No advantage is gained by preoperative bowel preparation in radical cystectomy and ileal conduit: a randomized controlled trial of 86 patients. Int Urol Nephrol. 2010 Dec;42(4):947–50. DOI: 10.1007/s11255-010-9732-9.

Cerantola Y, Hьbner M, Grass F, Demartines N, Schдfer M. Immunonutrition in gastrointestinal surgery. Br J Surg. 2011 Jan;98(1):37–48. DOI: 10.1002/bjs.7273.

Smith I, Kranke P, Murat I, Smith A, O’Sullivan G, Sшreide E, et al. Perioperative fasting in adults and children: guidelines from the European Society of Anaesthesiology. Eur J Anaesthesiol. 2011 Aug;28(8):556–69. DOI: 10.1097/EJA.0b013e3283495ba1.

Gustafsson UO, Scott MJ, Schwenk W, Demartines N, Roulin D, Francis N, et al. Enhanced Recovery After Surgery (ERAS) Society, for Perioperative Care; European Society for Clinical Nutrition and Metabolism(ESPEN); International Association for Surgical Metabolism and Nutrition (IASMEN). Guidelines for perioperative care in elective colonic surgery: Enhanced Recovery After Surgery (ERAS(®)) Society recommendations. World J Surg. 2013 Feb;37(2):259–84. DOI: 10.1007/s00268-012-1772-0.

Liu SS, Wu CL. Effect of postoperative analgesia on major postoperative complications: a systematic update of the evidence. Anesth Analg. 2007 Mar;104(3):689–702. DOI: 10.1213/01.ane.0000255040.71600.41.

Low J, Johnston N, Morris C. Epidural analgesia: first do no harm. Anaesthesia. 2008 Jan;63(1):1–3. DOI: 10.1111/j.1365-2044.2007.05407.x.

Published

2019-03-29

Issue

Section

Oncourology