DOI: https://doi.org/10.15587/2519-4852.2018.129599

Methodological approaches to the search of new herbal anticonvulsants

Yuliya Prokopenko, Victoriya Georgiyants

Abstract


 

Aim. Development of the most appropriate algorithm for the search and selection of herbs showing anticonvulsant properties, as well as to interpret the level of anticonvulsant activity of different groups of herbal substances using PASS tool.

Methods. Literature analysis and PASS software were used for development of a clear algorithm for finding the most suitable herbs having anticonvulsant activity.

Results. The most rational decision in case of development of the algorithms for the targeted search of herbs for epilepsy treatment is to divide herbal objects according to their chemical composition and mechanism of action. It was found that certain groups of biologically active compounds (alkaloids, flavonoids, phenolic acids) and some members of the Betulaceae, Papaveraceae, Solanaceae, Fumariaceae, Lamiaceae, Polemoniaceae, Viscaceae, and Oleaceae families have anticonvulsant activity. PASS analysis resulted that antiepileptic activity is inherent, but not significant for most of the studied compounds. Particular expectations caused the analysis of the results of alkaloids protopine and sanguinarine due to their high indexes of activity – 0.813 and 0.820 %, respectively.

Conclusion. The algorithm for selection of the most promising herbs for the further detailed phytochemical and pharmacological studies concerning possibilities of their use for treatment of epilepsy was substantiated. PASS prediction analysis for different groups of herbal substances was carried out. As expected, according to the PASS prediction results, antiepileptic activity is inherent, but not significant for most of the studied compounds. The analyzed compounds have the likelihood of manifestation of antiepileptic activity: the indexes of activity of the analyzed substances are in range from 0.430 to 0.754 %. Several biologically active compounds may have neuroprotector activity; the highest indexes were obtained for histidine (0.680 %) and alanine (0.718 %). Amino acids asparagine and serine have shown probable presence of cognition activator activity (0.489 % and 0.554 %, respectively)


Keywords


antiepileptic activity; herbs; herbal substances; algorithm; PASS tool; index of activity

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References


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GOST Style Citations


Plants and Plant Products with Potential Anticonvulsant Activity – A Review / Kumar S. et. al. // Pharmacognosy Communications. 2012. Vol. 2, Issue 1. P. 3–99. doi: 10.5530/pc.2012.suppl1.2 

Nsour W. M., Lau C. B.-S., Wong I. C. K. Review on phytotherapy in epilepsy // Seizure. 2000. Vol. 9, Issue 2. P. 96–107. doi: 10.1053/seiz.1999.0378 

Influence of dry herbal extracts on pentylenetetrazole-induced seizures in mice: screening results and relationship “chemical composition – pharmacological effect” / Tsyvunin V. et. al. // ScienceRise: Pharmaceutical Science. 2016. Issue 1 (1). P. 18–28. doi: 10.15587/2519-4852.2016.71518 

Krovat E., Steindl T., Langer T. Recent Advances in Docking and Scoring // Current Computer Aided-Drug Design. 2005. Vol. 1, Issue 1. P. 93–102. doi: 10.2174/1573409052952314 

Discriminating between Drugs and Nondrugs by Prediction of Activity Spectra for Substances (PASS) / Anzali S. et al. // Journal of Medicinal Chemistry. 2001. Vol. 44, Issue 15. P. 2432–2437. doi: 10.1021/jm0010670 

Mathews G. C. The Dual Roles of GABA in Seizures and Epilepsy Generate More Excitement. Epilepsy Currents. 2007. Vol. 7, Issue 1. P. 28–30. doi: 10.1111/j.1535-7511.2007.00159.x 

In Vivo Anticonvulsant Activity of Extracts and Protopine from the Fumaria schleicheri Herb / Prokopenko Y. et. al. // Scientia Pharmaceutica. 2015. Vol. 84, Issue 3. P. 547–554. doi: 10.3390/scipharm84030547 

Mojaradl T. B., Roghani M. The anticonvulsant and antioxidant effects of berberine in kainate-induced temporal lobe epilepsy in rats // Basic and clinical neuroscience. 2014. Issue 5 (2). P. 124–130.

Anticonvulsant activity of solasodine isolated fromSolanum sisymbriifoliumfruits in rodents / Chauhan K. et. al. // Pharmaceutical Biology. 2010. Vol. 49, Issue 2. P. 194–199. doi: 10.3109/13880209.2010.508499 

Medicinal compounds with antiepileptic/anticonvulsant activities / Zhu H.-L. et. al. // Epilepsia. 2013. Vol. 55, Issue 1. P. 3–16. doi: 10.1111/epi.12463 

Herbal Products and GABA Receptors / Johnston G. A. R. et. al. // Encyclopedia of Neuroscience. 2009. P. 1095–1101. doi: 10.1016/b978-008045046-9.00868-8 

Protopine inhibits serotonin transporter and noradrenaline transporter and has the antidepressant-like effect in mice models / Xu L.-F. et. al. // Neuropharmacology. 2006. Vol. 50, Issue 8. P. 934–940. doi: 10.1016/j.neuropharm.2006.01.003 

Wasowski C., Marder M. Flavonoids as GABA receptor ligands: the whole story? // Journal of experimental pharmacology. 2012. Issue 4. P. 9–24. doi: 10.2147/jep.s23105 

Effects of atropine sulphate on seizure activity and brain damage produced by soman in guinea-pigs: ECoG correlates of neuropathology / Carpentier P. et. al. // Neurotoxicology. 2000. Issue 21 (4). P. 521–540.

Rosmarinic acid is anticonvulsant against seizures induced by pentylenetetrazol and pilocarpine in mice / Grigoletto J. et. al. // Epilepsy & Behavior. 2016. Vol. 62. P. 27–34. doi: 10.1016/j.yebeh.2016.06.037 







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