Design and implementation of green chemistry approaches into pharmaceutical analysys of benzydamine dosage formes
Aim. The development of the pharmaceutical industry of Ukraine and the world has led to an increase in the need for the use of hazardous and toxic chemicals and solvents, which affects the safety of the environment and directly employees of pharmaceutical companies.
Therefore, one of the solutions to this problem is the implementation of “green chemistry” approaches in pharmaceutical quality control laboratories.
Materials and methods. Chromatographic separation methods are used for the qualitative and quantitative analysis of raw materials and finished dosage forms, the determination of substances that are formed during the degradation of active substances and allow rapid analysis of complex mixtures.
Results. For the implementation of green chemistry principles in the laboratory of pharmaceutical companies, it is necessary to evaluate the possibility of using rapid quality control methods such as gas chromatography, ultra-high performance liquid chromatography, and absorption spectrophotometry in the ultraviolet and visible regions.
Conclusions. Approaches to "greening" of analytical procedures used in quality control of pharmaceuticals have been studied. Ways of implementation of modern approaches of methods of "green chemistry" to chromatographic methods are offered. On the basis of the developed decision tree the design of development and "greening" of the methods of quality control of benzidamine dosage forms is proposed
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