Preparation and study of the substance of multicomponent dry extract of Belisa as a stage of pharmaceutical development of sedative capsules
The aim. Scientifically and experimentally substantiate the production and study of the properties of the multicomponent dry extract of Belisa in order to formulate a capsule mixture based on it, taking into account the requirements of ICQ 8 “Pharmaceutical Development”.
Methods. Physico-chemical and pharmaco-technological research methods were used to determine moisture, bulk density and bulk density after shrinkage, fractional composition of the obtained multicomponent dry extract of Belisa and model mixtures with excipients based on it.
Results. As a result of experimental studies, a multicomponent dry extract of Belisa was obtained. Humidity, bulk density and bulk density after shrinkage, fluidity of the obtained extract and seven model mixtures with it were determined and microscopic analysis was performed. According to the results of the experiment, the dry extract without the addition of excipients for 2 days lost its flowability, which prompted the use of excipients in its subsequent technology. To improve the technological properties of the dry extract of Belisa, model samples were made with different excipients (Aerosil in the amount of 1, 2 and 3 % and maltodextrin in the amount of 2, 3 and 4 %) and with a different technology.
Conclusions. Physico-chemical and pharmaco-technological properties of multicomponent dry extract of Belisa and its model samples with a number of excipients were studied. Humidity, bulk density and bulk density after shrinkage, fractional composition were studied. According to the results of experimental researches the technology is developed and the technological scheme of obtaining the multicomponent dry extract of Belisa is made and critical parameters of its production are defined
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