Research of the choice of the basis of a semi-solid medicine with a semi-solid extract of Feverfew (Tanacetum parthenium)

Authors

DOI:

https://doi.org/10.15587/2519-4852.2021.225764

Keywords:

semi-solid dosage forms, semi-solid medicines, medicinal plants, Feverfew

Abstract

The aim. To conduct the research on the choice of the basis for a mild drug with a semi-solid extract of feverfew for use in dermatology.

Materials and methods. In the study of the solubility of a semi-solid extract of feverfew (SSFE) used the method of optical microscopy using a laboratory microscope “Konus Academy”. Determination of pH and homogeneity of the studied samples was performed according to the methods described in SPhU, Vol.1. The bioavailability of the model samples was investigated by diffusion in 3 % agar gel. Colloidal stability and thermal stability were determined according to the methods of GOST 29188.3-91. Measurements of rheological parameters were performed on a rotary viscometer “MYR 3000 V 2R” (Viskotech, Spain). Determination of particle distribution was performed using a laser diffraction analyzer of particle size Mastersizer 3000.

Results. The best results in determining the organoleptic properties, stability and degree of release of biologically active substances (BAS) showed samples prepared on emulgel and gel bases. Structural and mechanical parameters of the samples on these bases proved the presence of a non-Newtonian type of flow with plastic and thixotropic properties. When determining the distribution of SSFE particles by optical diffraction, their smaller size was determined in the sample on an emulgel basis in comparison with the gel.

Conclusions. Emulgel loaded with specific drugs has been found effective in some topical disorders, and it is emerging as potential drug delivery system in the area of dermatology. Since emu-lgel shows enhanced spreadability, adhesion, viscosity and extrusion. Based on the obtained results, an emulsion gel base was chosen as a carrier for a semi-solid drug with SSFE

Author Biographies

Mariia Velia, Bukovinian State Medical University

Lecturer

Department of Pharmacy

College of the Higher State Educational Institution of Ukraine "Bukovina State Medical University"

Olena Ruban , National University of Pharmacy

Doctor of Pharmaceutical Sciences, Professor, Head of Department

Department of Industrial Technology of Drugs

Maryna Khalavka , National University of Pharmacy

PhD, Assistant

Department of Industrial Technology of Drugs

Larisa Hohlova , National University of Pharmacy

PhD, Associate Professor

Department of Industrial Technology of Drugs

References

  1. Hordiei, K. R., Gontova, T. M., Serbin, A. G., Kotov, A. G., Kotova, E. E. (2019). Study of phenolic compounds in the Feverfew Herb by TLC and HPLC methods. Ukrainian biopharmaceutical journal, 3 (60), 64–70. doi: http://doi.org/10.24959/ubphj.19.225
  2. Sur, R., Martin, K., Liebel, F., Lyte, P., Shapiro, S., Southall, M. (2008). Anti-Inflammatory Activity of Parthenolide-Depleted Feverfew (Tanacetum parthenium). Inflammopharmacology, 17 (1), 42–49. doi: http://doi.org/10.1007/s10787-008-8040-9
  3. Konovalova, D. S., Konovalov, D. A. (2008). Seskviterpenovye laktony piretruma devichego kak biologicheski aktivnye veschestva (obzor). Ekologiia cheloveka, 3, 3–7.
  4. Pareek, A., Suthar, M., Rathore, G., Bansal, V. (2011). Feverfew (Tanacetum parthenium L.): A systematic review. Pharmacognosy Reviews, 5 (9), 103–110. doi: http://doi.org/10.4103/0973-7847.79105
  5. Ruban, O. A., Pertsev, I. M., Kutsenko, S. A., Maslii, Yu. S.; Pertsev, I. M. (Ed.) (2016). Dopomizhni rechovyny u vyrobnytstvi likiv. Kharkiv: Zoloti storinky, 720.
  6. Rowe, R. C., Sheskey, P. J., Cook, W. G., Fenton, M. E. (Eds.) (2012). Handbook of Pharmaceutical Excipients. London: Pharmaceutical Press, 1064.
  7. Derzhavna farmakopeia Ukrainy. Vol. 1. (2015). Kharkiv: Derzhavne pidpryiemstvo «Ukrainskyi naukovyi farmakopeinyi tsentr yakosti likarskykh zasobiv», 1128.
  8. European Pharmacopoeia (2016). European Directorate for the Quality of Medicines (EDQM). Strasbourg: Council of Europe, 4016.
  9. Velia, M. I., Khalavka, M. V., Ruban, O. A. (2019). Vyznachennia rozchynnosti hustoho ekstraktu maruny divochoi (Tanacetum parthenium (Feverfew)) mikroskopichnym metodom. Tekhnolohichni ta biofarmatsevtychni aspekty stvorennia likarskykh preparativ riznoi napravlenosti dii. Kharkiv: Vyd-vo NFaU, 58–61.
  10. Lauterbach, A., Müller-Goymann, C. C. (2014). Comparison of rheological properties, follicular penetration, drug release, and permeation behavior of a novel topical drug delivery system and a conventional cream. European Journal of Pharmaceutics and Biopharmaceutics, 88 (3), 614–624. doi: http://doi.org/10.1016/j.ejpb.2014.10.001
  11. Kulkarni, V. S., Shaw, C. (2016). Particle Size Analysis: An Overview of Commonly Applied Methods for Drug Materials and Products. Essential Chemistry for Formulators of Semisolid and Liquid Dosages, 137–144. doi: http://doi.org/10.1016/b978-0-12-801024-2.00008-x
  12. Dhamoon, R., Popli, H., Aggarwal, G., Gupta, M. (2018). Particle Size Characterization- Techniques, Factors and Quality-by-design Approach. International Journal of Drug Delivery, 10, 1–11.
  13. Dhawas, V., Dhabarde, D., Patil, S. (2020). Emulgel: A Comprehensive Review for Novel Topical Drug Delivery System. International Journal of Recent Scientific Research, 11 (4), 38134–38138.
  14. Sahu, T., Patel, T., Sahu, S., Gidwani, B. (2016). Skin cream as topical drug delivery system: a review. Journal of Pharmaceutical and Biological Sciences, 4 (5), 149–154.
  15. Sharadha M, Gowda D V, Vishal Gupta N, Akhila A R. (2020). An overview on topical drug delivery system – Updated review. International Journal of Research in Pharmaceutical Sciences, 11 (1), 368–385. doi: http://doi.org/10.26452/ijrps.v11i1.1831
  16. Tanaji, D. N. (2018). Emulgel: A Comprehensive Review for Topical Delivery of Hydrophobic Drugs. Asian Journal of Pharmaceutics, 12 (2), 382–393. doi: http://doi.org/10.22377/ajp.v12i02.2366

Downloads

Published

2021-02-27

How to Cite

Velia, M., Ruban , O. ., Khalavka , M. ., & Hohlova , L. . (2021). Research of the choice of the basis of a semi-solid medicine with a semi-solid extract of Feverfew (Tanacetum parthenium). ScienceRise: Pharmaceutical Science, (1 (29), 51–59. https://doi.org/10.15587/2519-4852.2021.225764

Issue

Section

Pharmaceutical Science