Wound healing effect of “Prolidoxid” and “Dexpanthenol with ceramides”: a сomparative study based on the model of chemical burns with expressed alterative skin processes

Authors

DOI:

https://doi.org/10.15587/2519-4852.2021.230031

Keywords:

chemical wounds, dexpanthenol, ceramides, propolis, lidocaine, wound-healing effect, anti-inflammatory effect, healing area, cream, ointment

Abstract

Pharmacotherapy of chemical skin injuries remains an urgent issue today due to its serious health consequences and possible development of complications. Topical treatment is one of the most effective methods of wound treatment using hydrophilic ointments and creams. For now, range of hydrophilic medicinal products with a broad spectrum of action is limited. That is why a search and development of new hydrophilic ointments and creams remains an urgent challenge.

The aim. The aim of this research was to study effectiveness of ointment “Prolidoxid” and cream “Dexpanthenol with ceramides” on the experimental chemical burn model in rats.

Materials and methods. Wound healing effect of ointment “Prolidoxid” and cream “Dexpanthenol with ceramides” was proved by the study of planimetric and hematological parameters on the model of acetic acid burns in rats.

Results. Using animal model of chemical burns it was found that ointment “Prolidoxid” and cream “Dexpanthenol with ceramides” accelerate wound healing on Day 5 and Day 6, consequently, compared to untreated control animals, but in comparison with the action of reference medicine wounds were healed two days faster. Hematological parameters showed that studied medicines inhibit inflammation and reactivate blood rheological properties.

Conclusions. The results suggest that effectiveness of cream “Dexpanthenol with ceramides” is higher than for one-component cream “Dexpanthenol”, but ointment “Prolidoxid” exceeds therapeutic action of ointment “Wundahyl” as reported by hematological and planimetric parameters

Author Biographies

Yaroslava Butko, National University of Pharmacy

Doctor of Pharmaceutical Sciences, Professor

Department of Pharmacology and Pharmacotherapy

Oksana Tkachova, National University of Pharmacy

Doctor of Pharmaceutical Sciences, Professor

Department of Pharmaceutical Management and Marketing

Tetyana Tishakova, Kharkiv National Medical University

PhD, Associated Professor

Department of Medical and Bioorganic Chemistry

Anatoly Gordienko, National Technical University “Kharkiv Polytechnic Institute”

Doctor of Pharmaceutical Sciences, Professor

Department of Organic Synthesis and Nanotechnology

Yevhen Bondariev, National University of Pharmacy

Doctor of Pharmaceutical Sciences, Associate Professor

Department of Clinical Pharmacology

Institute for Advanced Training of Pharmacy Specialists

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Published

2021-04-30

How to Cite

Butko, Y., Tkachova, O., Tishakova, T., Gordienko, A. ., & Bondariev, Y. (2021). Wound healing effect of “Prolidoxid” and “Dexpanthenol with ceramides”: a сomparative study based on the model of chemical burns with expressed alterative skin processes. ScienceRise: Pharmaceutical Science, (2 (30), 26–32. https://doi.org/10.15587/2519-4852.2021.230031

Issue

No. 2 (30) (2021)

Section

Pharmaceutical Science

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Copyright (c) 2021 Yaroslava Butko, Oksana Tkachova, Tetyana Tishakova, Anatoly Gordienko, Yevhen Bondariev

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