The study of hepatoprotective influence of anti-diabetic herbal tea on the histological state of liver in rats with streptozotocin nicotinamide induced diabetes type 2

Authors

  • Альона Олександрівна Савич I. Horbachevsky Ternopil State Medical University Svobody sq., 1, Ternopil, Ukraine, 46001, Ukraine https://orcid.org/0000-0001-6053-7625
  • Світлана Михайлівна Марчишин SHEI «I. Ya. Horbachevsky Ternopil State Medical University» 1 Maidan Voli, Ternopil, Ukraine, 46002, Ukraine
  • Юлія Борисівна Лар’яновська I. Horbachevsky Ternopil State Medical University Svobody sq., 1, Ternopil, Ukraine, 46001, Ukraine

DOI:

https://doi.org/10.15587/2519-4852.2016.87255

Keywords:

type 2 diabetes, Streptozotocin, Nicotinamide, decoction, anti-diabetic herbal tea, histological study, hepatocytes

Abstract

Aim of research was to study hepatoprotective influence of the anti-diabetic herbal tea comparing with Metformin tablets and “Arphasetin” tea during experimental type 2 diabetes using liver tissue histological research.

Materials and methods. Experimental type 2 diabetes was reproduced by the single intravenous administration of Streptozotocin (STZ “Sigma”, USA) in the dose of 65 mg/kg.

Results. It was experimentally determined that the administration of the anti-diabetic herbal tea decoction in the dose of 9 mg/kg in rats having diabetes type 2, induced by Streptozotocin in the dose of 65 mg/kg and Nicotinamide in the dose of 230 mg/kg administration, prevents microcirculation disorders and contributes preservation trabecular structure of hepatic fates. Hepatolysis and degeneration of hepatocytes signs are less expressed, glycogen is better stored in cells, and the number of lipid droplets decreases. Anisonucleosis occurs more rarely, cells nuclei are better contoured, the number of dual cells and euchromatin content increase.

Conclusion. The effect of the anti-diabetic herbal tea is similar to the effect of the reference drug Metformin and better than the effect of “Arphasetin” tea, in terms of expressiveness positive influence on diabetegen toxic-degenerative action’s morphological signs. Thus, the administration of the anti-diabetic herbal tea in the dose of 9 mg/kg decreases destructive and degenerative changes of the structural and functional organization of liver of the rats with experimental diabetes type 2

Author Biographies

Альона Олександрівна Савич, I. Horbachevsky Ternopil State Medical University Svobody sq., 1, Ternopil, Ukraine, 46001

Applicant

Department of Pharmacognosy with Medical Botany

Світлана Михайлівна Марчишин, SHEI «I. Ya. Horbachevsky Ternopil State Medical University» 1 Maidan Voli, Ternopil, Ukraine, 46002

Doctor of pharmaceutical sciences, Professor, head of the department

Department of pharmacognosy with a medical botany

Юлія Борисівна Лар’яновська, I. Horbachevsky Ternopil State Medical University Svobody sq., 1, Ternopil, Ukraine, 46001

Doctor of pharmaceutical sciences, professor, head of the department

Department of Pharmacognosy with Medical Botany

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Published

2016-12-28

How to Cite

Савич, А. О., Марчишин, С. М., & Лар’яновська, Ю. Б. (2016). The study of hepatoprotective influence of anti-diabetic herbal tea on the histological state of liver in rats with streptozotocin nicotinamide induced diabetes type 2. ScienceRise: Pharmaceutical Science, (4 (4), 36–42. https://doi.org/10.15587/2519-4852.2016.87255

Issue

No. 4 (4) (2016)

Section

Pharmaceutical Science

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Copyright (c) 2016 Світлана Михайлівна Марчишин, Альона Олександрівна Савич, Юлія Борисівна Лар’яновська

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