DOI: https://doi.org/10.15587/2519-4852.2017.91071

Research of the influence of germanium coordination compounds with niacin and oxyethylidendiphosphonic acid on fatty acid composition of blood serum lipids

Iryna Nizhenkovska, Violetta Narokha, Anastasia Bakun, Tatyana Bruzgina

Abstract


The aim of research was to study the influence of Germanium coordination compounds with Niacin (МІГУ-1) and Germanium with nicotinic and oxyethylidendiphosphonic acids (OE-5) on fatty acid composition of blood serum lipids in rats.

Methods. Gas chromatography method was used by the authors.

Results. The influence of Germanium coordination compounds with Niacin (МІГУ-1) in the doses of 70 mg/kg, 30 mg/kg, and 10 mg/kg; Germanium with nicotinic and oxyethylidendiphosphonic acids (OE-5) in the doses of 20 mg/kg, 10 mg/kg, and 5 mg/kg; as well as nicotinic acid in the doses of 100mg/kg, 70 mg/kg, 30 mg/kg, and 10 mg/kg on fatty acid composition of blood serum lipids in rats was studied.

Conclusion. Germanium coordination compounds with Niacin kept more pronounced effect, comparing to nicotinic acid, on the fatty acids ratio in blood serum in animals by increasing the unsaturated fatty acids content and decreasing the saturated fatty acids content. Therefore, the further study of displayed compounds as potential drugs for prevention of the cardiovascular system diseases is promising


Keywords


Germanium; nicotinic acid; fatty acids; lipids; bisphosphonates; blood serum; dosage

References


Jiang, J., Yao, S., Cai, H.-H., Yang, P.-H., Cai, J. (2013). Synthesis and synergetic effects of chrysin–organogermanium (IV) complex as potential anti-oxidant. Bioorganic & Medicinal Chemistry Letters, 23 (20), 5727–5732. doi: 10.1016/j.bmcl.2013.07.073

Lavigne, P. M., Karas, R. H. (2013). The Current State of Niacin in Cardiovascular Disease Prevention. Journal of the American College of Cardiology, 61 (4), 440–446. doi: 10.1016/j.jacc.2012.10.030

Wolfe, F., Bolster, M. B., O’Connor, C. M., Michaud, K., Lyles, K. W., Colón-Emeric, C. S. (2013). Bisphosphonate use is associated with reduced risk of myocardial infarction in patients with rheumatoid arthritis. Journal of Bone and Mineral Research, 28 (5), 984–991. doi: 10.1002/jbmr.1792

European Convention for the Protection of Vertebrate Animals used for Experimental and Other Scientific Purposes (1991). Available at: http://conventions.coe.int/treaty/en/treaties/html/123.htm

Nizhenkovs'ka, I. V., Sejfullina, I. J., Naroha, V. P., Chebanenko, O. A., Kuznecova, O. V., Marcynko, O. E., Brjuzgina, T. S. (2015). The influence of niacin and complex compound of Germanium with niacin (MIGU-1) on the fatty composition of cardiomyocytes lipids and hepatocytes of rats with experimental chronic heart failure. Pharmacology and Drug toxicology, 1 (42), 68–75.

Petri, A., Sebin, K. (2003). Transparent statistics in medicine. Moscow: GEOTAR-media, 143.

Kotuginska, S., Gozhenko, A., Vaksuk, V., Sharipov, K., Kirgizbaeva, A. (2015). Comparative characteristics of the state of lipid transport system. Vestnik KazNMU, 1, 470–474.

Heemskerk, M. M., Dharuri, H. K., van den Berg, S. A. A., Jonasdottir, H. S., Kloos, D.-P., Giera, M. et. al. (2014). Prolonged niacin treatment leads to increased adipose tissue PUFA synthesis and anti-inflammatory lipid and oxylipin plasma profile. The Journal of Lipid Research, 55 (12), 2532–2540. doi: 10.1194/jlr.m051938

Zhang, Y., Yang, X., Shi, H., Dong, L., Bai, J. (2011). Effect of α-linolenic acid on endoplasmic reticulum stress-mediated apoptosis of palmitic acid lipotoxicity in primary rat hepatocytes. Lipids in Health and Disease, 10 (1), 122. doi: 10.1186/1476-511x-10-122

Carlson, L. A., Hamsten, A., Asplund, A. (1989). Pronounced lowering of serum levels of lipoprotein Lp(a) in hyperlipidaemic subjects treated with nicotinic acid. Journal of Internal Medicine, 226 (4), 271–276. doi: 10.1111/j.1365-2796.1989.tb01393.x

Kostyuk, V. A., Potapovich, A. I., Strigunova, E. N., Kostyuk, T. V., Afanas’ev, I. B. (2004). Experimental evidence that flavonoid metal complexes may act as mimics of superoxide dismutase. Archives of Biochemistry and Biophysics, 428 (2), 204–208. doi: 10.1016/j.abb.2004.06.008

Lee, J.-S., Park, J.-I., Kim, S.-H., Park, S.-H., Kang, S., Park, C.-B. et. al. (2004). Oral single- and repeated-dose toxicity studies on Geranti Bio-Ge yeast, organic germanium fortified yeasts, in rats. The Journal of Toxicological Sciences, 29 (5), 541–553. doi: 10.2131/jts.29.541


GOST Style Citations


Jiang, J. Synthesis and synergetic effects of chrysin-organogermanium (IV) complex as potential antioxidant [Text] / J. Jiang, S. Yao, H.-H. Cai, P.-H. Yang, J. Cai // Bioorganic & Medicinal Chemistry Letters. – 2013. – Vol. 23, Issue 20. – P. 5727–5732. doi: 10.1016/j.bmcl.2013.07.073

Lavigne, P. M. The current state of niacin in cardiovascular disease prevention: A systematic review and meta-regression [Text] / P. M. Lavigne, R. H. Karas // Journal of the American College of Cardiology. – 2013. – Vol. 61, Issue 4. – P. 440–446. doi: 10.1016/j.jacc.2012.10.030

Wolfe, F. Bisphosphonate use is associate with reduces risk of myocardial infarction in patients with rheumatoid arthritis [Text] / F. Wolfe, M. Bolster, C. O`Connor, K. Michaud, K. W. Lyles, C. S. Colon-Emeric // Journal of Bone and Mineral Research. – 2013. – Vol. 28, Issue 5. – P. 984–991. doi: 10.1002/jbmr.1792

Европейская конвенция о защите позвоночных животных, используемых для экспериментов или в иных научных целях [Электронный ресурс]. – 1991. – Режим доступа: http://conventions.coe.int/treaty/en/treaties/html/123.htm

Ніженковська, І. В. Вплив нікотинової кислоти та комплексу германію з нікотиновою кислотою (МІГУ-1) на жирнокислотний склад ліпідів кардіоміоцитів та гепатоцитів щурів з експериментальною хронічною серцевою недостатність [Текст] / І. В. Ніженковська, І. Й. Сейфулліна, В. П. Нароха, О. А. Чебаненко, О. В. Кузнецова, О. Е. Марцинко, Т. С. Брюзгіна // Фармакологія та лікарська токсикологія. – 2015. – T. 1, № 42. – С. 68–75.

Петри, А. Наглядная статистика в медицине [Текст]: уч. пос. / А. Петри, К. Сэбин. – М.: ГЭОТАР-Медиа, 2003. – 143 с.

Котюжинская, С. Г. Сравнительная характеристика состояния липидтранспортной системы [Текст] / С. Г. Котюжинская, А. И. Гоженко, В. Л. Ваксюк, К. О. Шарипов, А. А. Киргизбаева // Вестник КазНМУ. – 2015. – № 1. – С. 470–474.

Heemskerk, M. M. Prolonged niacin treatment leads to increased adipose tissue PUFA synthesis and anti-inflammatory lipid and oxylipin plasma profil [Text] / M. M. Heemskerk, H. K. Dharuri, S. A. A. van den Berg, H. S. Jonasdottir, D.-P. Kloos, M. Giera et. al. // The Journal of Lipid Research. – 2014. – Vol. 55, Issue 12. – P. 2532–2540. doi: 10.1194/jlr.m051938

Zhang, Y. Effect of α-linolenic acid on endoplasmic reticulum stress-mediated apoptosis of palmitic acid lipotoxicity in primary rat hepatocytes [Text] / Y. Zhang, X. Yang, H. Shi, L. Dong, J. Bai // Lipids in Health and Disease. – 2011. – Vol. 10, Issue 1. – P. 122. doi: 10.1186/1476-511x-10-122

Carlson, L. A. Pronounced lowering of serum levels of lipoprotein lp(a) in hyperlipidaemic subjects treated with nicotinic acid [Text] / L. A. Carlson, A. Hamsten, A. J. Asplund // Journal of Internal Medicine. – 1989. – Vol. 226, Issue 4. – P. 271–276. doi: 10.1111/j.1365-2796.1989.tb01393.x

Kostyuk, V. A. Experimental evidence that flavonoid metal complexes may act as mimics of superoxide dismutase [Text] / V. A. Kostyuk, A. I. Potapovich, E. N. Strigunova, T. V. Kostyuk, I. B. Afanas'ev // Archives of Biochemistry and Biophysics. – 2004. – Vol. 428, Issue 2. – P. 204–208. doi: 10.1016/j.abb.2004.06.008

Lee, J.-S. Oral single- and repeated-dose toxicity studies on Geranti Bio-Ge yeast, organic germanium fortified yeasts, in rats [Text] / J.-S. Lee, J.-I. Park, S.-H. Kim, S.-H. Park, S. Kang, C.-B. Park et. al. // The Journal of Toxicological Sciences. – 2004. – Vol. 25, Issue 5. – P. 541–555. doi: 10.2131/jts.29.541







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