Research of the influence of germanium coordination compounds with niacin and oxyethylidendiphosphonic acid on fatty acid composition of blood serum lipids

Authors

DOI:

https://doi.org/10.15587/2519-4852.2017.91071

Keywords:

Germanium, nicotinic acid, fatty acids, lipids, bisphosphonates, blood serum, dosage

Abstract

The aim of research was to study the influence of Germanium coordination compounds with Niacin (МІГУ-1) and Germanium with nicotinic and oxyethylidendiphosphonic acids (OE-5) on fatty acid composition of blood serum lipids in rats.

Methods. Gas chromatography method was used by the authors.

Results. The influence of Germanium coordination compounds with Niacin (МІГУ-1) in the doses of 70 mg/kg, 30 mg/kg, and 10 mg/kg; Germanium with nicotinic and oxyethylidendiphosphonic acids (OE-5) in the doses of 20 mg/kg, 10 mg/kg, and 5 mg/kg; as well as nicotinic acid in the doses of 100mg/kg, 70 mg/kg, 30 mg/kg, and 10 mg/kg on fatty acid composition of blood serum lipids in rats was studied.

Conclusion. Germanium coordination compounds with Niacin kept more pronounced effect, comparing to nicotinic acid, on the fatty acids ratio in blood serum in animals by increasing the unsaturated fatty acids content and decreasing the saturated fatty acids content. Therefore, the further study of displayed compounds as potential drugs for prevention of the cardiovascular system diseases is promising

Author Biographies

Iryna Nizhenkovska, Bogomolets National Medical University 13 Shevchenko boul., Kyiv, Ukraine, 01601

MD, professor, head of the department

Department of pharmaceutical, biological and toxicological chemistry

Violetta Narokha, Bohomolets National Medical University T. Shevchenka blvd., 13, Kyiv, Ukraine, 01601

Assistant

Department of pharmaceutical, biological and toxicological chemistry

Anastasia Bakun, Bohomolets National Medical University T. Shevchenka blvd., 13, Kyiv, Ukraine, 01601

Laboratory assistant

Department of pharmaceutical, biological and toxicological chemistry

Tatyana Bruzgina, Bohomolets National Medical University T. Shevchenka blvd., 13, Kyiv, Ukraine, 01601

PhD, Leading Researcher

Institute of Experimental and clinical medicine 

References

  1. Jiang, J., Yao, S., Cai, H.-H., Yang, P.-H., Cai, J. (2013). Synthesis and synergetic effects of chrysin–organogermanium (IV) complex as potential anti-oxidant. Bioorganic & Medicinal Chemistry Letters, 23 (20), 5727–5732. doi: 10.1016/j.bmcl.2013.07.073
  2. Lavigne, P. M., Karas, R. H. (2013). The Current State of Niacin in Cardiovascular Disease Prevention. Journal of the American College of Cardiology, 61 (4), 440–446. doi: 10.1016/j.jacc.2012.10.030
  3. Wolfe, F., Bolster, M. B., O’Connor, C. M., Michaud, K., Lyles, K. W., Colón-Emeric, C. S. (2013). Bisphosphonate use is associated with reduced risk of myocardial infarction in patients with rheumatoid arthritis. Journal of Bone and Mineral Research, 28 (5), 984–991. doi: 10.1002/jbmr.1792
  4. European Convention for the Protection of Vertebrate Animals used for Experimental and Other Scientific Purposes (1991). Available at: http://conventions.coe.int/treaty/en/treaties/html/123.htm
  5. Nizhenkovs'ka, I. V., Sejfullina, I. J., Naroha, V. P., Chebanenko, O. A., Kuznecova, O. V., Marcynko, O. E., Brjuzgina, T. S. (2015). The influence of niacin and complex compound of Germanium with niacin (MIGU-1) on the fatty composition of cardiomyocytes lipids and hepatocytes of rats with experimental chronic heart failure. Pharmacology and Drug toxicology, 1 (42), 68–75.
  6. Petri, A., Sebin, K. (2003). Transparent statistics in medicine. Moscow: GEOTAR-media, 143.
  7. Kotuginska, S., Gozhenko, A., Vaksuk, V., Sharipov, K., Kirgizbaeva, A. (2015). Comparative characteristics of the state of lipid transport system. Vestnik KazNMU, 1, 470–474.
  8. Heemskerk, M. M., Dharuri, H. K., van den Berg, S. A. A., Jonasdottir, H. S., Kloos, D.-P., Giera, M. et. al. (2014). Prolonged niacin treatment leads to increased adipose tissue PUFA synthesis and anti-inflammatory lipid and oxylipin plasma profile. The Journal of Lipid Research, 55 (12), 2532–2540. doi: 10.1194/jlr.m051938
  9. Zhang, Y., Yang, X., Shi, H., Dong, L., Bai, J. (2011). Effect of α-linolenic acid on endoplasmic reticulum stress-mediated apoptosis of palmitic acid lipotoxicity in primary rat hepatocytes. Lipids in Health and Disease, 10 (1), 122. doi: 10.1186/1476-511x-10-122
  10. Carlson, L. A., Hamsten, A., Asplund, A. (1989). Pronounced lowering of serum levels of lipoprotein Lp(a) in hyperlipidaemic subjects treated with nicotinic acid. Journal of Internal Medicine, 226 (4), 271–276. doi: 10.1111/j.1365-2796.1989.tb01393.x
  11. Kostyuk, V. A., Potapovich, A. I., Strigunova, E. N., Kostyuk, T. V., Afanas’ev, I. B. (2004). Experimental evidence that flavonoid metal complexes may act as mimics of superoxide dismutase. Archives of Biochemistry and Biophysics, 428 (2), 204–208. doi: 10.1016/j.abb.2004.06.008
  12. Lee, J.-S., Park, J.-I., Kim, S.-H., Park, S.-H., Kang, S., Park, C.-B. et. al. (2004). Oral single- and repeated-dose toxicity studies on Geranti Bio-Ge yeast, organic germanium fortified yeasts, in rats. The Journal of Toxicological Sciences, 29 (5), 541–553. doi: 10.2131/jts.29.541

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Published

2017-02-28

How to Cite

Nizhenkovska, I., Narokha, V., Bakun, A., & Bruzgina, T. (2017). Research of the influence of germanium coordination compounds with niacin and oxyethylidendiphosphonic acid on fatty acid composition of blood serum lipids. ScienceRise: Pharmaceutical Science, (1 (5), 32–35. https://doi.org/10.15587/2519-4852.2017.91071

Issue

No. 1 (5) (2017)

Section

Pharmaceutical Science

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Copyright (c) 2017 Ірина Володимирівна Ніженковська, Віолетта Петрівна Нароха, Анастасія Віталіївна Бакун, Тетяна Семенівна Брюзгіна

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