The effect of sodium chondroitin sulfate on free-radical processes in cartilage tissue of rats with osteoarthrosis

Authors

  • Yelizaveta Tikhova Taras Shevchenko National University of Kyiv Volodymyrska str., 64/13, Kyiv, Ukraine, 01601, Ukraine
  • Katerina Dvorshchenko Taras Shevchenko National University of Kyiv Volodymyrska str., 64/13, Kyiv, Ukraine, 01601, Ukraine
  • Oleksandr Korotkyi Taras Shevchenko National University of Kyiv Volodymyrska str., 64/13, Kyiv, Ukraine, 01601, Ukraine
  • Volodymyr Vereschaka Taras Shevchenko National University of Kyiv Volodymyrska str., 64/13, Kyiv, Ukraine, 01601, Ukraine

DOI:

https://doi.org/10.15587/2519-8025.2017.109318

Keywords:

osteoarthrosis, oxide stress, peroxide oxidation of lipids, cartilages, chondroitin sulfate

Abstract

It was established, that at osteoarthrosis, induced by the administration of monoiodine acetate, the oxide stress develops in the cartilage tissue of knee joints, at that the content of active forms of oxygen and products of lipids peroxide oxidation grows, especially: hydrogen peroxide, superoxide-anion radical, dienoic conjugates, RBA-active products and Schiff bases. Activities of xantinoxidase prooxidant enzyme and antioxidant superoxidysmutase also grew at the pathology. It was revealed, that at administering the preparation on the base of chondroitin sulfate, the content of active forms of oxygen and products of lipids peroxide oxidation decreased in the cartilage tissue of rats with chemically induced osteoarthrosis. The negative control proved that the preparation on the base of chondroitin sulfate doesn’t influence the shift of the prooxidant-antioxidant balance in experimental animals. The obtained data testify to antioxidant properties of this preparation

Author Biographies

Yelizaveta Tikhova, Taras Shevchenko National University of Kyiv Volodymyrska str., 64/13, Kyiv, Ukraine, 01601

Postgarduate student

Department of Biochemistry

ESC "Institute of Biology and Medicine"

Katerina Dvorshchenko, Taras Shevchenko National University of Kyiv Volodymyrska str., 64/13, Kyiv, Ukraine, 01601

Doctor of Biological Sciences, Head of the Research Laboratory

Laboratory "Biochemistry"

ESC "Institute of Biology and Medicine"

Oleksandr Korotkyi, Taras Shevchenko National University of Kyiv Volodymyrska str., 64/13, Kyiv, Ukraine, 01601

PhD, Associate Professor

Department of Biochemistry

NSC "Institute of Biology and Medicine"

Volodymyr Vereschaka, Taras Shevchenko National University of Kyiv Volodymyrska str., 64/13, Kyiv, Ukraine, 01601

MD, Senior Researcher

Department of SRL "Physico-chemical biology"        

ESC "Institute of Biology and Medicine"

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Published

2017-08-31

How to Cite

Tikhova, Y., Dvorshchenko, K., Korotkyi, O., & Vereschaka, V. (2017). The effect of sodium chondroitin sulfate on free-radical processes in cartilage tissue of rats with osteoarthrosis. ScienceRise: Biological Science, (4 (7), 26–30. https://doi.org/10.15587/2519-8025.2017.109318

Issue

No. 4 (7) (2017)

Section

Biological Sciences

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Copyright (c) 2017 Katerina Dvorshchenko, Oleksandr Korotkyi, Volodymyr Vereschaka, Yelizaveta Tikhova

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