Change in biochemical profile of rats under carbon tetrachloride-induced liver injury

Authors

  • Тетяна Іванівна Галенова Taras Shevchenko National University of Kyiv Volodymirska str., 64, Kyiv, Ukraine, 01601, Ukraine
  • Наталія Григорівна Ракша Taras Shevchenko National University of Kyiv Volodymirska str., 64, Kyiv, Ukraine, 01601, Ukraine
  • Олексій Миколайович Савчук Taras Shevchenko National University of Kyiv Volodymirska str., 64, Kyiv, Ukraine, 01601, Ukraine

DOI:

https://doi.org/10.15587/2519-8025.2016.81836

Keywords:

blood biochemical parameters, cytokines, antioxidant enzymes, toxic liver injury

Abstract

The carbon tetrachloride-induced rat model of liver injury was described. Changes in serum biochemical parameters indicate a progressive process of the hepatocyte destruction and intrahepatic cholestasis, which most likely is the result of oxidative stress activation in response to toxicants. Our results also demonstrated an imbalance of pro- and anti-inflammatory cytokines under conditions of tetrachloroethane intoxication

Author Biographies

Тетяна Іванівна Галенова, Taras Shevchenko National University of Kyiv Volodymirska str., 64, Kyiv, Ukraine, 01601

PhD, senior researcher

Наталія Григорівна Ракша, Taras Shevchenko National University of Kyiv Volodymirska str., 64, Kyiv, Ukraine, 01601

PhD, senior researcher

Олексій Миколайович Савчук, Taras Shevchenko National University of Kyiv Volodymirska str., 64, Kyiv, Ukraine, 01601

Doctor of Biological Science, professor

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Published

2016-11-03

How to Cite

Галенова, Т. І., Ракша, Н. Г., & Савчук, О. М. (2016). Change in biochemical profile of rats under carbon tetrachloride-induced liver injury. ScienceRise: Biological Science, (2 (2), 47–54. https://doi.org/10.15587/2519-8025.2016.81836

Issue

No. 2 (2) (2016)

Section

Biological Sciences

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Copyright (c) 2016 Тетяна Іванівна Галенова, Наталія Григорівна Ракша, Олексій Миколайович Савчук

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