Β-lactam antibiotics in Ukraine: market and consumption analysis in 2013–2018

Authors

DOI:

https://doi.org/10.15587/2519-4852.2019.165682

Keywords:

pharmaceutical market, β-lactam antibiotics, consumption of medicines, ATC/DDD methodology

Abstract

The strategy of combating the development of antibiotic resistance is a global challenge for the scientific community for the sake of life and health of the population. An analysis of the relationship between the levels of antimicrobial drug consumption and the development of antibiotic resistance is one of the tools to contain the resistance. An increase in the consumption of antimicrobial drugs may not significantly reduce the possibility of treating infectious diseases.

According to reports from the European Surveillance of Antimicrobial Consumption Network, β-lactam antimicrobial drugs are the most consumed antibiotic group in Europe among other. The consumption level of β-lactams in Ukraine is significantly lower than in the Europe. Such data require a detailed assessment of the level of consumption of β-lactam antimicrobial drugs, for individual INN and analysis of the balance of their use.

The aim of the work is to analyze the market and consumption of antimicrobial drugs of the β-lactam group in Ukraine for 2013-2018 with the help of the ATC / DDD methodology, as well as comparison of the obtained consumption volumes with similar results in the European Union.

Results. The total amount of AMP of the β-lactam group presented in the Ukrainian market in 2018 is 343 trade names (TN), of which 92 are domestic and 251 are foreign manufactured, which indicates the high saturation of the Ukrainian pharmaceuticals by imported drugs

In Ukraine, in 2017, penicillins consumed 4.48 times less than the EU average, while cephalosporins and carbapenems are almost the same.

The most commonly used INNs from the penicillin group – Amoxicillin and Amoxicillin with β-lactamase inhibitors, and the leaders in terms of consumption among cephalosporins are medicines for CITIs Ceftriaxone and Cefuroxime.

Conclusions. Antimicrobials of the β-lactam group are well-studied and widely used in medical practice. They are widely represented in the Ukrainian market (343 TN), but only less than a third of them (92 TN) of domestic production, which indicates the high saturation of the Ukrainian pharmaceutical market with imported drugs. The volume of antimicrobial drugs used in the β-lactam group in Ukraine is almost 4.5 times lower than in the EU.

The most commonly used drugs are Amoxicillin, from a group of penicillins with extended spectrum. Cefriaxone and Cefuroxime are most commonly used drugs among cephalosporins

Author Biographies

Larysa Yakovlieva, National University of Pharmacy Pushkinska str., 53, Kharkiv, Ukraine, 61002

Doctor of Pharmaceutical Sciences, Professor, Merited worker of science and technology of Ukraine, Head of Department

Department of Pharmacoeconomics

Tetiana Bahlai, National University of Pharmacy Pushkinska str., 53, Kharkiv, Ukraine, 61002

Аспирант

Кафедра фармакоэкономики

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Published

2019-04-30

How to Cite

Yakovlieva, L., & Bahlai, T. (2019). Β-lactam antibiotics in Ukraine: market and consumption analysis in 2013–2018. ScienceRise: Pharmaceutical Science, (2 (18), 16–21. https://doi.org/10.15587/2519-4852.2019.165682

Issue

No. 2 (18) (2019)

Section

Pharmaceutical Science

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Copyright (c) 2019 Larysa Yakovlieva, Tetiana Bahlai

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