Studies of physico-chemical and pharmaco-technological parameters of bioflavonoids diosmin and hesperidin
Keywords:diosmin, hesperidin, pharmaco-technological study, microscopically researches, moisture absorption, solubility, derivatographic characteristics
The use of medicinal substances of herbal origin are perspective direction for the development sector of the pharmaceutical industry of healthcare in Ukraine, even though increased demand for synthetic medicines. The natural substances that have a wide range of therapeutic effects, low toxicity and can be used in therapy of anorectal diseases is diosmin and hesperidin. In the pharmaceutical market of Ukraine the substances of diosmin and hesperidin are presented as solid dosage forms, which can be used for treatment of chronic venous insufficiency. It is appropriate to development composition and technology of new combination dosage form, which can purposefully release active substances in the places of progressing pathological process. The definition of substance properties is based on a comprehensive research, which results will have a significant impact on the technology of obtaining a new drug.
The aim of the work was physic-chemical and pharmaco-technological researches of substances diosmin and hesperidin.
Results. The result of our work were carrying out a microscopic research, which is confirming results a differential curve of particle distribution, studied derivatographic characteristics of the substances, moisture absorption and solubility. Based on the research it can be concluded about insufficient solubility of diosmin and hesperidin, their high hygroscopicity and high critical degradation of substances. According to the results of microscopic analysis, diosmin has a few fractions with different distributions of particles and hesperidin has capable of agglomeration.
Conclusions. On the basis of research it can be concluded for the feasibility of further research, which can improve properties of the substances diosmin and hesperidin. The results of research can be concluded, that conducted results will have impact on development of the composition and technology of the new dosage form with diosmin and hesperidin
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