Peculiarities of disorders of nitrogen oxide system in the blood at adrenalin-induced myocardial injury in conditions of immobilization stress and their correction by L-arginine

Authors

DOI:

https://doi.org/10.15587/2519-4852.2021.238320

Keywords:

Free arginine, nitric oxide system indicators, adrenaline-induced myocardial injury, immobilization stress

Abstract

The aim: of the study was to elucidate the changes to nitric oxide activity in the blood during adrenaline-induced myocardial injury under immobilization stress and to establish the corrective effect of L-arginine.

Methods: determination of free arginine was conducted by the method of Aleinikova T.L., total nitric oxide products in the blood by the method of Schmidt H.H., the total activity of nitric oxide synthase by the method of Sumbaiev V.V.. Immobilization stress was reproduced by the method of Horizontov P.D. Adrenaline-induced myocardial injury was reproduced by the method of Markova O.O. L-arginine was injected based on scientific data by Kiryanova N.A.

Results. Studies have shown that on days 1 and 3 with adrenaline-induced myocardial injury under immobilization stress there was an increase in nitric oxide products in the blood, respectively, according to control. The use of L-arginine on the 5th day, led to a decrease in levels of NO products in the blood by less than, lower against the group of animals with MI and IS, to treatment.

Conclusions. Thus, biochemical studies of NO system in the dynamics of IS and MI showed an increase in food content and total synthase activity of NO on the background of reduced levels of L-arginine, which were detected at all stages of the study and especially expressed on the 1st day before treatment. The use of the drug L-arginine, made it possible to identify its corrective effect on impaired metabolic processes in MI and IS

Author Biographies

Oksana Lys, Danylo Halytskyi Lviv National Medical University

Postgraduate Student

Department of Pathological Physiology

Mykhailo Reheda, Danylo Halytskyi Lviv National Medical University

Doctor of Medical Sciences, Professor

Department of Pathological Physiology

Nataliya Sementsiv, Danylo Halytskyi Lviv National Medical University

PhD

Department of Pathological Physiology

Mariana Reheda-Furdychko, Lviv Medical Institute

Doctor of Medical Sciences

Department of Anatomy Physiology and Pathology

Stepan Reheda, Danylo Halytskyi Lviv National Medical

Doctor of Philosophy

Department of Surgical and Orthopedic Dentistry

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Published

2021-08-31

How to Cite

Lys, O., Reheda, M., Sementsiv, N., Reheda-Furdychko, M., & Reheda, S. (2021). Peculiarities of disorders of nitrogen oxide system in the blood at adrenalin-induced myocardial injury in conditions of immobilization stress and their correction by L-arginine. ScienceRise: Pharmaceutical Science, (4(32), 24–28. https://doi.org/10.15587/2519-4852.2021.238320

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Pharmaceutical Science