Application of statistical tools for the formulation and optimization of carvedilol mucoadhesive buccal films by using natural polymers

Authors

DOI:

https://doi.org/10.15587/2519-4852.2023.273548

Keywords:

natural polymers, mucoadhesive, Carvedilol, buccal film, in vitro studies

Abstract

The aim and objective of this study was to create mucoadhesive buccal films that contained the multipurpose medical carvedilol, which has a variety of medicinal uses.

Materials and methods. The films were equipped using a solvent casting technique and concentrations of natural polymers, including Sweet basil, Lime Basil seeds and Purple basil mucilage. The influence of Carbopol 934 P, a selected natural polymer, was also investigated. The formulation variables were improved by the use of a factorial design of experiments and evaluated for their physico-chemical and in vitro evaluations.

Result. These evaluations provided crucial insights into the properties of the buccal films. To evaluate the release profile and release kinetics of carvedilol from the films, in vitro drug release experiments were carried out in a phosphate buffer solution. Ex vivo permeation tests using fresh sheep buccal mucosa were performed to evaluate the drug's permeation through the buccal membrane. Samples were taken at regular intervals, and a UV Spectrophotometer was used for analysis. With a polymer solution concentration at level "3," formulation run R20 showed the best optimized buccal formulation. This formulation shows promise for further in vivo research.

Conclusions. The results of this study offer important new evidence about the design and efficacy of mucoadhesive buccal films containing carvedilol. The optimization of formulation parameters and the assessment of physicochemical properties and drug release kinetics contribute to the progress of reproducible buccal films

Author Biographies

Leela Lakshmi Vajrala, Jagan’s College of Pharmacy

Associate professor

Department of Pharmaceutics

Umashankar M S, SRM Institute of Science and Technology (formerly known as SRM University)

Doctor of Pharmaceutical Science, Professor

Department of Pharmaceutics

SRM College of Pharmacy

Alagusundaram M, Jagan’s College of Pharmacy; ITM University Gwalior

Professor

Department of Pharmaceutics;

Professor, Dean

School of Pharmacy

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Application of statistical tools for the formulation and optimization of carvedilol mucoadhesive buccal films by using natural polymers

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Published

2023-08-31

How to Cite

Vajrala, L. L., M S, U., & M, A. (2023). Application of statistical tools for the formulation and optimization of carvedilol mucoadhesive buccal films by using natural polymers. ScienceRise: Pharmaceutical Science, (4(44), 63–75. https://doi.org/10.15587/2519-4852.2023.273548

Issue

No. 4(44) (2023)

Section

Pharmaceutical Science

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Copyright (c) 2023 Leela Lakshmi Vajrala, Umashankar M S, Alagusundaram M

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