Experimental research on the development of composition of complex action ointment based on phytocomplex

Authors

DOI:

https://doi.org/10.15587/2519-4852.2023.286306

Keywords:

ointment base, emulsion ointment, composition, multicomponent phytoextract, tea tree essential oil, geranium essential oil

Abstract

The aim of the work is to develop the composition of a complex action ointment based on active pharmaceutical ingredients of natural origin for the treatment of cheilitis of various etiologies.

Materials and methods. The development of the ointment base by selecting active pharmaceutical ingredients and auxiliary substances determined by organoleptic, physicochemical, rheological and microbiological research methods.

Results. Studies of the antimicrobial activity of experimental samples have established that the optimal ointment base is a water/oil emulsion, which provides better API release rates than absorption bases.

According to the results of structural and mechanical studies, the introduction of the API complex reduces the structural viscosity of the ointment base. Furthermore, the ability of the ointment to thin out with an increase in the gradient of the shear rate is shown, which will contribute to the uniform distribution of the API during the technological process and the easy application of the ointment to the skin.

The study of textural properties of the experimental ointment samples (cohesion, adhesion, and elasticity) also confirmed the satisfactory spreadability of the sample. The optimal container for its consistent properties was chosen according to the results of the ointment's structural, mechanical and textural properties.

A test of the effectiveness of antimicrobial preservatives was conducted, resulting in the minimum effective concentration of sodium benzoate in the amount of 1 % was substantiated. Furthermore, based on the results of a complex of studies, the composition of the emulsion ointment was developed, which includes vaseline (liquid paraffin) 20 %, emulsifiers glycerol monostearate 5.5 %, polysorbate-80 3.5 %, viscosity regulator of the aqueous phase hydroxyethyl cellulose 3 %, phytocomplex API "Phytol" (concentrated aqueous extract of burdock root: oak bark: pot marigold flower in the ratio 5:1:1.5, respectively) and essential oils of tea tree 1 % and geranium 1.5 %, purified water.

Conclusions. Based on organoleptic, physicochemical, rheological and microbiological studies, the composition of the ointment of complex action was developed based on active pharmaceutical ingredients of natural origin for the treatment of cheilitis of various etiologies.

Author Biographies

Ksenia Matsiuk, National University of Pharmacy

Postgraduate Student

Department of Pharmaceutical Technology of Drugs

Tetiana Kovalova, National University of Pharmacy

PhD, Associate Professor

Department of Pharmaceutical Technology of Drugs

Yuliia Maslii, National University of Pharmacy

PhD, Associate Professor

Department of Industrial Technology of Drugs

Nataliia Herbina, National University of Pharmacy

PhD, Associate Professor

Department of Industrial Technology of Drugs

Liliia Vyshnevska, National University of Pharmacy

Doctor of Pharmaceutical Sciences, Professor, Head of Department

Department of Pharmaceutical Technology of Drugs

Olha Kaliuzhnaia, National University of Pharmacy

PhD, Associate Professor

Department of Biotechnology

Oksana Tkachuk, Rivne Medical Academy

PhD, Senior Lecturer

Department of Chemical and Pharmaceutical Disciplines

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Experimental research on the development of composition of complex action ointment based on phytocomplex

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Published

2023-08-31

How to Cite

Matsiuk, K., Kovalova, T., Maslii, Y., Herbina, N., Vyshnevska, L., Kaliuzhnaia, O., & Tkachuk, O. (2023). Experimental research on the development of composition of complex action ointment based on phytocomplex. ScienceRise: Pharmaceutical Science, (4(44), 19–27. https://doi.org/10.15587/2519-4852.2023.286306

Issue

No. 4(44) (2023)

Section

Pharmaceutical Science

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Copyright (c) 2023 Ksenia Matsiuk, Tetiana Kovalova, Yuliia Maslii, Nataliia Herbina, Liliia Vyshnevska, Olha Kaliuzhnaia, Oksana Tkachuk

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