Development of an emulsion composition with fennel and caraway essential oils for use in the combined therapy of ulcerative colitis

Oleksandr Shmalko; Tetiana Kovalova; Liubov Bodnar; Volodymyr Kovalov; Volodymyr Yakovenko; Liliia Vyshnevska

doi:10.15587/2519-4852.2024.302941

Authors

Oleksandr Shmalko Petro Mohyla Black Sea National University, Ukraine https://orcid.org/0000-0002-5777-0896
Tetiana Kovalova National University of Pharmacy, Ukraine https://orcid.org/0000-0002-5984-6196
Liubov Bodnar National University of Pharmacy, Ukraine https://orcid.org/0000-0002-3268-0683
Volodymyr Kovalov National University of Pharmacy, Ukraine https://orcid.org/0000-0003-1603-2771
Volodymyr Yakovenko National University of Pharmacy, Ukraine http://orcid.org/0000-0002-9348-7764
Liliia Vyshnevska National University of Pharmacy, Ukraine https://orcid.org/0000-0002-6887-3591

DOI:

https://doi.org/10.15587/2519-4852.2024.302941

Keywords:

ulcerative colitis, intestinal disorders, oral microemulsion, Fennel and Caraway essential oil

Abstract

The aim of the study is to develop the composition of an emulsion containing essential oils of Fennel and Caraway seeds for use in the symptomatic complex therapy of ulcerative colitis with the aim of eliminating functional intestinal disorders.

Materials and methods. The objects of the study were samples of emulsions containing active pharmaceutical ingredients (essential oils of Fennel and Caraway), purified water, oils (refined sunflower oil, refined olive oil, refined sesame oil), emulsifiers (polyethylene glycol 40 hydrogenated castor oil, polysorbate 80, polyethylene glycol 100 stearate, acacia gum, guar gum, xanthan gum, soya lecithin), viscosity regulator - apple pectin and flavouring agents (food additives with cherry and tarragon flavour).

Organoleptic properties, stability, rheological parameters, pH, particle size determination by microscopy, and a taste test were carried out with model emulsion samples. Research to establish the optimal technological parameters was carried out in parallel.

Results. The main parameters of the technological process have been established, which allow to obtain an emulsion with evenly distributed particles: 15 minutes at maximum speed. The concentration of emulsifiers at which the emulsions are stable was selected. It was found that the samples containing polyethylene glycol 100 stearate, gums, and soy lecithin have satisfactory organoleptic properties.

The sample with soy lecithin emulsifier differs from the others in its ability to form microemulsions, but it has low viscosity. To improve the rheological properties, apple pectin was added to the emulsion.

The taste test showed that among vegetable oils, refined sesame oil has a more neutral taste, and the flavouring additive "Tarkhun" balances the taste better.

The release of active pharmaceutical ingredients (APIs) from the emulsion base was confirmed by thin-layer chromatography.

Conclusions. A microemulsion with essential oils based on refined sesame oil, soy lecithin, with the addition of viscosity and flavour correctors was developed. The obtained emulsion has satisfactory organoleptic properties and conforms to the requirements for emulsion quality indicators

Author Biographies

Oleksandr Shmalko, Petro Mohyla Black Sea National University

Associate Professor

Department of Pharmacy, Pharmacology, Medical, Bioorganic and Biological Chemistry

Medical Institute

Tetiana Kovalova, National University of Pharmacy

PhD, Associate Professor

Department of Pharmaceutical Technology of Drugs

Liubov Bodnar, National University of Pharmacy

Postgraduate Student

Department of Pharmaceutical Technology of Drugs

Volodymyr Kovalov, National University of Pharmacy

PhD, Philosophy Doctor, Associate Professor

Department of Pharmaceutical Technology of Drugs

Volodymyr Yakovenko, National University of Pharmacy

Doctor of Pharmaceutical Science, Professor

Department of Industrial Pharmacy and Economics

Liliia Vyshnevska, National University of Pharmacy

Doctor of Pharmaceutical Science, Professor, Head of Department

Department of Pharmaceutical Technology of Drugs

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