Study of the chemical components of CO2 extracts from the fruits of Sorbus aucuparia L.




Sorbus aucuparia L., GC-MS analysis, CO2 extraction, fatty acid


The article presents the results of the study of the chemical composition of Sorbus aucuparia L. СО2 subcritical extract.

For the first time in Kazakhstan, 20 grams of brown Sorbus aucuparia L. extract were collected using subcritical carbon dioxide extraction. The current study was directed mainly to the chemical compositions of subcritical Sorbus aucuparia L. СО2 subcritical extract.

The Sorbus aucuparia L. extract's chemical compositions were determined using gas chromatography/mass spectrophotometry (GC-MS). The extract included the following main compounds: 5-Methyl-2(3H)-furanone (30.18 %), 5-(3-Ethoxy-4,5-dihydro-isoxazol-5-yl)-5-methyl-imidazolidine-2,4-dione (3.20 %), 4H-Pyran-4-one, 2,3-dihydro-3,5-dihydroxy-6-methyl (2.53 %). Determined fatty acid profile and the moisture content of raw vegetable ingredients of Sorbus substance.

Quantitative determination of fatty acids of ethanol extract was carried out. The results of the analysis for fatty acids in the study showed that linoleic (37.7 %) and oleic (50.5 %) were the most prominent fatty acids.

The aim of this study is to determine the component composition by using the GC-MS method and fatty acid to study the Sorbus aucuparia L. extract obtained by CO2 extraction, which grows in Kazakhstan.

Materials and methods. To determine the possibility of using Sorbus aucuparia L., we carried out the composition and fatty acid of the extract obtained by CO2 extraction in subcritical conditions of Sorbus aucuparia L. by a certain GC-MS method.

Results. The raw materials of the plant were collected in accordance with GACP requirements. Conducted subcritical CO2 extraction of plant raw materials showed a 20 g extraction yield. Chemical compounds were discovered, bioactive components were identified, such as 5-Methyl-2(3H)-furanone (30.18 %), 5-(3-Ethoxy-4,5-dihydro-isoxazol-5-yl)-5-methyl-imidazolidine-2,4-dione (3.20 %), 4H-Pyran-4-one, 2,3-dihydro-3,5-dihydroxy-6-methyl (2.53 %).

Conclusions. The possibility of using the obtained CO2 extract of Sorbus aucuparia L. in the field of pharmaceutical products as a substance and a drug

Author Biographies

Serzhan Mombekov, S. D. Asfendiyarov Kazakh National Medical University

PhD, Associate Professor

School of Pharmacy

Ubaidilla Datkhayev, S. D. Asfendiyarov Kazakh National Medical University

Doctor of Pharmaceutical Sciences, Professor

School of Pharmacy

Dosmagulova Kalamkul, Arkalyk State Pedagogical Institute named after I. Altynsarin

Master of Education Sciences

Faculty of Natural Science and Informatization

Assel Kozhamzharova, S. D. Asfendiyarov Kazakh National Medical University

Associate Professor

School of Pharmacy

Ainash Baidullayeva, S. D. Asfendiyarov Kazakh National Medical University

Assistant Teacher

Department of Engineering Disciplines and Good Practices

School of Pharmacy

Mukhamejan Assel, S. D. Asfendiyarov Kazakh National Medical University

Master Student

School of Pharmacy

Aigerim Kantureyeva, S. D. Asfendiyarov Kazakh National Medical University

PhD Student

School of Pharmacy

Zura Yessimsiitova, Al-Farabi Kazakh National University

PhD, Associate Professor

Faculty of biology and biotechnology

Damira Yussayeva, Al-Farabi Kazakh National University


Faculty of Biology and Biotechnology

Zaure Beken, S. D. Asfendiyarov Kazakh National Medical University

Department of Biological Chemistry

Akmaral Kydyrkhanova, Al-Farabi Kazakh National University

Faculty of Biology and Biotechnology

Aidana Karbozova, Al-Farabi Kazakh National University

Department of Biodiversity and Bioresources

Faculty of Biology and Biotechnology

Iryna Zhuravel, National University of Pharmacy

Doctor of Chemical Sciences, Professor

Department of Pharmaceutical Technology, Standardization and Certification of Medicines


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Study of the chemical components of CO2 extracts from the fruits of Sorbus aucuparia L.




How to Cite

Mombekov, S., Datkhayev, U., Kalamkul, D., Kozhamzharova, A., Baidullayeva, A., Assel, M., Kantureyeva, A., Yessimsiitova, Z., Yussayeva, D., Beken, Z., Kydyrkhanova, A., Karbozova, A., & Zhuravel, I. (2024). Study of the chemical components of CO2 extracts from the fruits of Sorbus aucuparia L. ScienceRise: Pharmaceutical Science, (2 (48), 83–89.



Pharmaceutical Science