Pharmacological and technological studies in the development of tablet composition with acorus calamus leaf extract

Authors

DOI:

https://doi.org/10.15587/2519-4852.2024.306558

Keywords:

Acorus calamus, quercetin, tablets, gastrointestinal tract, relatively therapeutic dose

Abstract

The aim: To determine the optimal qualitative and quantitative composition of auxiliary substances for tablets containing dry extract of Acorus calamus leaves and the solid dispersion of quercetin, their relatively therapeutic dose and antiexudative activity.

Materials and methods: This study determined a relatively therapeutic dose of dry extract of Acorus calamus leaves, investigated the impact of various auxiliary substances on the properties of tablets formulated with active ingredients - dry extract of Acorus calamus leaves and solid dispersion of quercetin, and assessed antiexudative activity these tablets. The comprehensive analysis entailed the utilization of standardized pharmacopoeial methods to evaluate the quality of the tablet samples. These methods encompassed a range of assessments designed to ensure that the tablets met the requisite pharmacological standards, focusing on key characteristics such as dissolution rate and stability. Determination of the relatively therapeutic dose and antiexudative activity made using standard pharmacological methods in laboratory rats.

Results: In-depth exploration during the study led to identifying Ac-Di-Sol and Lubripharm SSF as the most suitable auxiliary substances for the tablet composition. Detailed analysis revealed that Ac-Di-Sol, when utilized at a 10 % concentration, markedly improved the tablets' disintegration rate without adversely affecting their structural integrity. Concurrently, Lubripharm SSF was observed to significantly enhance the tablets' mechanical stability by reducing their friability.

Conclusions: As a result of the study, the relatively therapeutic dose of dry extract of Acorus calamus leaves, and the solid dispersion of quercetin, optimal auxiliary substances for the tablet formulation - Ac-Di-Sol and Lubripharm SSF - were established. The conducted research enabled the development of a tablet composition that aligns with the requisite pharmacotechnological specifications and conditions of the modern pharmaceutical industry and demonstrates high antiexudative activity relative to monocomponent substances and famous drugs

Author Biographies

Oleksiy Andryushayev, National University of Pharmacy

PhD Student

Department of Industrial Technology of Drugs

Yevhenii Samoilov, National University of Pharmacy

PhD Student

Department of Pharmacology and Pharmacotherapy

Valeriia Hnatiuk, Bogomolets National Medical University

Doctor of Medicine Sciences, Associate Professor

Department of Pharmacology

Olena Ruban, National University of Pharmacy

Doctor of Pharmaceutical Sciences, Professor, Head of Department

Department of Industrial Technology of Drugs

Mariia Velia, Bukovinian State Medical University

PhD, Assistant

Department of Pharmacy

Maryna Savokhina, National University of Pharmacy

PhD, Associate Professor

Department of Pharmacology and Pharmacotherapy

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Pharmacological and technological studies in the development of tablet composition with acorus calamus leaf extract

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Published

2024-06-30

How to Cite

Andryushayev, O., Samoilov, Y., Hnatiuk, V., Ruban, O., Velia, M., & Savokhina, M. (2024). Pharmacological and technological studies in the development of tablet composition with acorus calamus leaf extract. ScienceRise: Pharmaceutical Science, (3 (49), 27–36. https://doi.org/10.15587/2519-4852.2024.306558

Issue

No. 3 (49) (2024)

Section

Pharmaceutical Science

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Copyright (c) 2024 Oleksiy Andryushayev, Yevhenii Samoilov, Valeriia Hnatiuk, Olena Ruban, Mariia Velia, Maryna Savokhina

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