The assessment of homogeneity of gel on polimetilsiloxan basis containing extracts of quince leaves and grapes waste products for its technology optimization and improvement

Authors

  • Елена Васильевна Кузнецова Shupyk National Medical Academy of Postgraduate Education Dorogozhytska str., 9, Kyiv, Ukraine, 04112, Ukraine https://orcid.org/0000-0002-4655-9868
  • Вікторія Євгеніївна Буцька Shupyk National Medical Academy of Postgraduate Education Dorogozhytska str., 9, Kyiv, Ukraine, 04112, Ukraine https://orcid.org/0000-0001-6360-394X
  • Олександр Геннадійович Тимченко Shupyk National Medical Academy of Postgraduate Education Dorogozhytska str., 9, Kyiv, Ukraine, 04112, Ukraine https://orcid.org/0000-0003-2052-5165
  • Тетяна Віталіївна Джан Kyiv international university Lvivska str., 49, Kyiv, Ukraine, 03179, Ukraine

DOI:

https://doi.org/10.15587/2519-4852.2016.81479

Keywords:

technology, gel, extracts, Quince, Grapes waste products, temperature modes, mixing, microscopy

Abstract

Aim. To optimize technology of gel on Polimetilsiloxan basis containing extracts of Quince leaves and Grapes waste products for high quality drug with optimal shelf life creation.

Methods. Pharmaceutical technology (particles size study by microscopy), physical and chemical methods were used.

Results. Technological parameters of gel preparation were described. Technology of gel on Polimetilsiloxan basis containing extracts of Quince leaves and Grapes waste products was chosen by research results. Microscopy pictures of the studied gel samples were obtained using microscopy analysis of the gel structure. The gel has a structure of free created rigid matrix, built after polycondensation processes of methyl silantriole and siloxane bounds between silicon atoms. It has been experimentally proven that the structure of the finished drug on Polimetilsiloxan basis containing extracts of Quince leaves and Grapes waste products, prepared at temperature of 60 oС and mixing speed 1500 rpm, consists on equally distributed microparticles having almost identical form and adjacent to each other more tightly. The chosen technological modes are characterized by better microstructure ordering compared to their analogues at using other process parameters. Gel samples have satisfactory values of physical and chemical parameters.

Conclusion. Technological parameters for obtaining of gel on Polimetilsiloxan basis containing extracts of Quince leaves and Grapes waste products were determined and substantiated

Author Biographies

Елена Васильевна Кузнецова, Shupyk National Medical Academy of Postgraduate Education Dorogozhytska str., 9, Kyiv, Ukraine, 04112

Department of Industrial, of clinical pharmacy and Clinical Pharmacology

Вікторія Євгеніївна Буцька, Shupyk National Medical Academy of Postgraduate Education Dorogozhytska str., 9, Kyiv, Ukraine, 04112

PhD, Associate professor

Department of Industrial, of clinical pharmacy and Clinical Pharmacology

Олександр Геннадійович Тимченко, Shupyk National Medical Academy of Postgraduate Education Dorogozhytska str., 9, Kyiv, Ukraine, 04112

PhD, Associate professor

Department of Industrial, of clinical pharmacy and Clinical Pharmacology

Тетяна Віталіївна Джан, Kyiv international university Lvivska str., 49, Kyiv, Ukraine, 03179

PhD, Associate professor

Department of Pharmacy

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Published

2016-10-30

How to Cite

Кузнецова, Е. В., Буцька, В. Є., Тимченко, О. Г., & Джан, Т. В. (2016). The assessment of homogeneity of gel on polimetilsiloxan basis containing extracts of quince leaves and grapes waste products for its technology optimization and improvement. ScienceRise: Pharmaceutical Science, (3 (3), 60–64. https://doi.org/10.15587/2519-4852.2016.81479

Issue

No. 3 (3) (2016)

Section

Pharmaceutical Science

License

Copyright (c) 2016 Елена Васильевна Кузнецова, Вікторія Євгеніївна Буцька, Олександр Геннадійович Тимченко, Тетяна Віталіївна Джан

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