Influence of peach leaf extract on the metabolic processes and prooxidant/antioxidant balance in rats in conditions of chronic immobilization stress

Authors

DOI:

https://doi.org/10.15587/2519-4852.2017.92521

Keywords:

thick extract, peach ordinary (Persica vulgaris), immobilization stress, metabolism, stressprotective effect

Abstract

The aim - research of stressprotective action of thick extract of peach ordinary (Persica vulgaris) leaf (TEPL) on the impact on metabolism, antioxidant system and lipid peroxidation in conditions of chronic stress.

Materials and methods. Chronic stress was caused daily four hour immobilization of rats in tight boxes for 18 days. TEPL in a dose 100 mg/kg and reference drug syrup "Imunoton" in a dose of 15 ml/kg was administered before 5 days to the experiment and every day for 40 minutes before stress exposure. After 18 days lipid metabolism: level of triglycerides (TG) and total cholesterol in serum; carbohydrate metabolism: level of glucose in blood serum and liver glycogen were determined. State of the system lipid peroxidation / antioxidant protection (LPO / AOP) was assessed by the level of thiobarbituric acid reagents (TBA-Rs), reduced glutathione (SH) and catalase activity, cytolytic processes was assessed by the level of ALT in blood serum.

Results: TEPL and reference drug "Imunoton" in comparison with a group of untreated animals reduced levels of triglyceride respectively 1.7 and 2.1 times (p<0.05) and cholesterol 1.5 (p<0.05) and 1.2 times (p> 0.05) and levels of glucose in the blood serum respectively 1.5 and 1.4 times (p<0.05) and liver glycogen respectively 3.2 and 2.6 times (p<0.05), the marker of cytolysis ALT respectively 1.2 times (p<0.05) and increased the level of the antioxidant enzyme catalase respectively 2.3 and 1.6 times (p<0.05).

Conclusions. Stressprotective effect of TEPL was expressed in normalization of hyperlipidemia, preservation of constancy in carbohydrate metabolism, cytolytic processes inhibition, antioxidant protection enhancing. Unlike TEPL reference drug "Imunoton" containing extracts of Eleutherococcus, St. John's wort, Echinacea and has adaptogenic, immunostimulative action did not show significant effect on high level of cholesterol. Antioxidant action of TEPL exceeded the effect of the drug "Imunoton".

Author Biographies

Ganna Zaychenko, Bohomolets National Medical University T. Shevchenka blvd., 13, Kyiv, Ukraine, 01601

MD, professor, head of department

Department of pharmacology

Chuгshed Sharifov, National University of Pharmacy Pushkinskaya str., 53, Kharkiv, Ukraine, 61002

Department of Clinical pharmacology

Oksana Mishchenko, National University of Pharmacy Pushkinskaya str., 53, Kharkiv, Ukraine, 61002

Doctor of pharmaceutical sciences, professor, head of department

Department of Clinical pharmacology

Elena Koshevaya, National University of Pharmacy Pushkinskaya str., 53, Kharkiv, Ukraine, 61002

PhD, senior researcher, Head of Laboratory

Central Research Laboratory

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Published

2017-02-28

How to Cite

Zaychenko, G., Sharifov, C., Mishchenko, O., & Koshevaya, E. (2017). Influence of peach leaf extract on the metabolic processes and prooxidant/antioxidant balance in rats in conditions of chronic immobilization stress. ScienceRise: Pharmaceutical Science, (1 (5), 13–16. https://doi.org/10.15587/2519-4852.2017.92521

Issue

No. 1 (5) (2017)

Section

Pharmaceutical Science

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Copyright (c) 2017 Ганна Володимирівна Зайченко, Хуршед Шералієвич Шаріфов, Оксана Яківна Міщенко, Олена Юріївна Кошева

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