Component composition and antimicrobial activity of subcritical CO2 extract of Ferula asafoetida L., growing in the territory of Kazakhstan

Authors

DOI:

https://doi.org/10.15587/2519-4852.2023.266654

Keywords:

Ferula asafoetida, GC-MS analysis, CO2 extraction, antimicrobial effect, component composition, plant raw materials, Ferula L., double serial dilutions method, disco-diffusion method

Abstract

Ferula asafoetida L. has been studied for centuries by many scientists as food products and in traditional medicine, which are relevant for Kazakhstan as well. Recent studies have shown that Ferula asafoetida L. has neuroprotective, memory-enhancing, digestive enzymatic, antioxidant, antispasmodic, hypotensive, hepatoprotective, antimicrobial, antitumor, cytotoxic, and anthelmintic effects.

The aim of this study is to determine the component composition by GC-MS method and to study the antimicrobial properties of Ferula asafoetida L. extract obtained by CO2 extraction, which grows in Kazakhstan.

Materials and methods. To determine the possibility of using Ferula asafoetida L., we carried out the component composition of the extract obtained by CO2 extraction in subcritical conditions of the underground part of Ferula asafoetida L. by a certain GC-MS method and also investigated the antimicrobial effect of this extract.

Results. The plant raw materials were collected in accordance with GACP requirements. Conducted subcritical CO2 extraction of plant raw materials showed a 2.5% extraction yield. The study of the component composition by GC-MS revealed 46.3% of sulfate compounds. The determination of antimicrobial activities showed high efficacy against gram-positive (Staphylococcus aureus subsp. Aureus, Bacillus subtilis subsp. Spizizenii), gram-negative bacteria (Escherichia coli, Klebsiella pneumoniae subsp. pneumoniae, Salmonella enterica subsp. enterica) and fungi (Candida albicans, Aspergillus niger).

Conclusions. The possibility of using the obtained CO2 extract of Ferula asafoetida L. in the field of pharmaceutical products as a substance and a drug that has a huge antimicrobial effect

Author Biographies

Nurgali Rakhymbayev, S. D. Asfendiyarov Kazakh National Medical University

School of Pharmacy

Ubaidilla Datkhayev, S. D. Asfendiyarov Kazakh National Medical University

Doctor of Pharmaceutical Sciences, Professor

School of Pharmacy

Bayan Sagindykova, South Kazakhstan Medical Academy

Doctor of Pharmaceutical Sciences, Professor

Diyas Myrzakozha, S. D. Asfendiyarov Kazakh National Medical University

Doctor of Chemical Sciences, Professor

School of Pharmacy

Kairat Zhakipbekov, S. D. Asfendiyarov Kazakh National Medical University

PhD, Associate Professor

School of Pharmacy

Zhanar Iskakbayeva, Scientific Center for Anti-Infectious Drugs

Microbiology Laboratory

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Component composition and antimicrobial activity of subcritical CO2 extract of Ferula asafoetida L., growing in the territory of Kazakhstan

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Published

2023-04-30

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Rakhymbayev, N., Datkhayev, U., Sagindykova, B., Myrzakozha, D., Zhakipbekov, K., & Iskakbayeva, Z. (2023). Component composition and antimicrobial activity of subcritical CO2 extract of Ferula asafoetida L., growing in the territory of Kazakhstan. ScienceRise: Pharmaceutical Science, (2(42), 82–91. https://doi.org/10.15587/2519-4852.2023.266654

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No. 2(42) (2023)

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Pharmaceutical Science

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Copyright (c) 2023 Nurgali Rakhymbayev, Ubaidilla Datkhayev, Bayan Sagindykova, Diyas Myrzakozha, Kairat Zhakipbekov, Zhanar Iskakbayeva

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