Study of the chemical components of CO2 extracts from the underground part of Ferula Asafoetida L.

Authors

DOI:

https://doi.org/10.15587/2519-4852.2025.323987

Keywords:

medicinal plants, plant raw materials, Ferula asafoetida L., CO2 extract, chemical compounds, fatty acids, amino acids, GC-MS

Abstract

The aim of this study was to determine the chemical composition of the CO2 extract obtained from the underground part of Ferula asafoetida L., a plant widely used in traditional Kazakhstani medicine, with a particular focus on the amino acid and fatty acid profiles.

Materials and methods. The plant material was collected in accordance with current Good Agricultural and Collection Practice (GACP) guidelines and underwent thorough pre-processing. A subcritical CO2 extraction method was applied to preserve thermolabile and volatile components while minimizing solvent residues. Chemical analysis was performed using GC-MS, and the amino acid and fatty acid profiles were determined by gas-liquid chromatography (GLC) based on standardized methods.

Results. The resulting CO₂ extract had a high proportion of unsaturated fatty acids (90.2 %), primarily oleic acid (46.1 %) and linoleic acid (43.0 %), along with a complete set of 20 amino acids, including 25.92 % essential amino acids. The major bioactive compounds identified were 9,12-Octadecadienoic acid, ethyl ester (18.61 %) and ethyl oleate (13.18 %), which have potential antioxidant and anti-inflammatory properties. These findings suggest the extract’s suitability for pharmaceutical and nutraceutical applications.

Conclusions. Although the extract shows promising potential for pharmaceutical applications, further verification through comprehensive pharmacological studies is necessary

Author Biographies

Serzhan Mombekov, S. D. Asfendiyarov Kazakh National Medical University

PhD, Associate Professor

School of Pharmacy

Nurgali Rakhymbayev, S. D. Asfendiyarov Kazakh National Medical University

PhD

School of Pharmacy

Kairat Zhakipbekov, S. D. Asfendiyarov Kazakh National Medical University

PhD, Associate Professor

School of Pharmacy

Bayan Sagindykova, South Kazakhstan Medical Academy

Doctor of Pharmaceutical Sciences, Professor

Faculty of Pharmacy

Symbat Akhatova, I. Altynsarin Arkalyk Pedagogical Institute

Master of Natural Sciences

Faculty of Natural Science and Informatization

Maral Amirov, I. Altynsarin Arkalyk Pedagogical Institute

Master of Natural sciences

Faculty of Natural Science and Informatization

Iryna Zhuravel, National University of Pharmacy

Doctor of Chemical Sciences, Professor

Department of Pharmaceutical Technology, Standardization and Certification of Medicines

Akmaral Nurmahanova, Al Farabi Kazakh National University

PhD, Associate Professor

Faculty of Biology and Biotechnology

Murat Ashirov, S. D. Asfendiyarov Kazakh National Medical University

Lecturer

School of Pharmacy

Arailym Daulbayeva, S. D. Asfendiyarov Kazakh National Medical University

PhD student

School of Pharmacy

Sergii Kolisnyk, National University of Pharmacy

Doctor of Pharmaceutical Sciences, Professor

Department of General Chemistry

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Study of the chemical components of CO2 extracts from the underground part of Ferula Asafoetida L.

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Published

2025-02-28

How to Cite

Mombekov, S., Rakhymbayev, N., Zhakipbekov, K., Sagindykova, B., Akhatova, S., Amirov, M., Zhuravel, I., Nurmahanova, A., Ashirov, M., Daulbayeva, A., & Kolisnyk, S. (2025). Study of the chemical components of CO2 extracts from the underground part of Ferula Asafoetida L. ScienceRise: Pharmaceutical Science, (1 (53), 115–122. https://doi.org/10.15587/2519-4852.2025.323987

Issue

No. 1 (53) (2025)

Section

Pharmaceutical Science

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Copyright (c) 2025 Serzhan Mombekov, Nurgali Rakhymbayev, Kairat Zhakipbekov, Bayan Sagindykova, Symbat Akhatova, Maral Amirov, Iryna Zhuravel, Akmaral Nurmahanova, Murat Ashirov, Arailym Daulbayeva, Sergii Kolisnyk

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