Застосування методу математичного планування для підбору допоміжних компонентів для створення лікувально-косметичного засобу функціонального призначення

Автор(и)

DOI:

https://doi.org/10.15587/2519-4852.2026.350751

Ключові слова:

лікувально-косметичний крем, метод математичного планування експерименту, рослинний екстракт , біофармацевтичні дослідження in vitro, сума флавоноїдів, високоефективна рідинна хроматографія, нікотинамід, саліцилова кислота, камфора, склад, технологія виготовлення

Анотація

Мета дослідження: підбір оптимального комплексу допоміжних речовин та розробка технології лікувально-косметичного крему для лікування акне.

Матеріали та методи. Як активні фармацевтичні інгредієнти були вибрані сухий екстракт «Фітоінфлам», нікотинамід, саліцилова кислота, камфора. Як допоміжні компоненти було використано двадцять інгредієнтів, що виконують функцію структуроутворювача, емульгатора, емоленту або масляної фази. Підбір допоміжних речовин проводили з використанням чотирифакторного плану на основі 5х5 греко-латинського квадрата. Дослідження in vitro проводили методом рівноважного діалізу через напівпроникну мембрану по Крувчинському. Кількісне визначення суми флавоноїдів перерахунку на рутин визначали методом високоефективної рідинної хроматографії.

Результати. Із застосуванням рангового критерію Дункана були визначені найбільш оптимальні допоміжні компоненти для крему, що розробляється: аеросил (структуроутворювач), натрію тетраборат (емульгатор), гліцерин (емолент) і рицинова олія (олійне середовище). Емпіричним методом була підібрана концентрація лимонної кислоти як регулятор рН: згідно з отриманими даними, найбільш оптимальною концентрацією є 1%.

Висновки. За результатами планування експерименту за планом греко-латинських квадратів 5х5 розроблено склад лікувально-косметичного крему емульсійного типу проти акне: сухий екстракт «Фітоінфлам», нікотинамід, саліцилова кислота, камфора, аеросил, тетраборат натрію, гліцерин, рицинова олія, лимонна кислота, ефірна олія чайного дерева, вода очищена. Виходячи з фізико-хімічних властивостей активних фармакологічних субстанцій та допоміжних речовин розроблено технологію отримання даного лікувально-косметичного крему

Біографії авторів

Ekut Karieva, Tashkent Pharmaceutical Institute

Doctor of Pharmaceutical Sciences, Professor, Head of Department

Department of Technology of Dosage Forms

Malika Baratova, Tashkent Pharmaceutical Institute

Department of Technology of Dosage Forms

Mukhammadjon Matazimov, Andijan Branch of Kokand University

Doctor Of Philosophy in Pharmaceutical Sciences (Phd)

Department of Biological Chemistry And Pharmaceutics

Олександр Сергійович Кухтенко, Національний фармацевтичний університет

Доктор фармацевтичних наук, професор, ректор

Посилання

  1. Hazarika, N. (2019). Acne vulgaris: new evidence in pathogenesis and future modalities of treatment. Journal of Dermatological Treatment, 32 (3), 277–285. https://doi.org/10.1080/09546634.2019.1654075
  2. Heath, C. R., Usatine, R. P. (2021). Acne vulgaris. The Journal of Family Practice, 70 (7), 356. https://doi.org/10.12788/jfp.0271
  3. Vasam, M., Korutla, S., Bohara, R. A. (2023). Acne vulgaris: A review of the pathophysiology, treatment, and recent nanotechnology based advances. Biochemistry and Biophysics Reports, 36, 101578. https://doi.org/10.1016/j.bbrep.2023.101578
  4. Chen, H., Zhang, T. C., Yin, X. L., Man, J. Y., Yang, X. R., Lu, M. (2022). Magnitude and temporal trend of acne vulgaris burden in 204 countries and territories from 1990 to 2019: an analysis from the Global Burden of Disease Study 2019. British Journal of Dermatology, 186 (4), 673–683. https://doi.org/10.1111/bjd.20882
  5. Tan, A. U., Schlosser, B. J., Paller, A. S. (2018). A review of diagnosis and treatment of acne in adult female patients. International Journal of Women’s Dermatology, 4 (2), 56–71. https://doi.org/10.1016/j.ijwd.2017.10.006
  6. Heng, A. H. S., Chew, F. T. (2020). Systematic review of the epidemiology of acne vulgaris. Scientific Reports, 10 (1). https://doi.org/10.1038/s41598-020-62715-3
  7. Zhu, Z., Zhong, X., Luo, Z., Liu, M., Zhang, H., Zheng, H., Li, J. (2024). Global, regional and national burdens of acne vulgaris in adolescents and young adults aged 10–24 years from 1990 to 2021: a trend analysis. British Journal of Dermatology, 192 (2), 228–237. https://doi.org/10.1093/bjd/ljae352
  8. Dias da Rocha, M. A., Saint Aroman, M., Mengeaud, V., Carballido, F., Doat, G., Coutinho, A., Bagatin, E. (2024). Unveiling the Nuances of Adult Female Acne: A Comprehensive Exploration of Epidemiology, Treatment Modalities, Dermocosmetics, and the Menopausal Influence. International Journal of Women’s Health, 16, 663–678. https://doi.org/10.2147/ijwh.s431523
  9. Tolino, E., Skroza, N., Proietti, I., Bernardini, N., Balduzzi, V., Anzalone, A. et al. (2021). Postacne scarring: which factors are involved? Giornale Italiano Di Dermatologia e Venereologia, 155 (6), 793–794. https://doi.org/10.23736/s0392-0488.19.06154-6
  10. Muzaffar, K. H., Halilu, H. B., Dantata, B. A., Saati, S. M., Salah, L. A. (2024). Prevalence of Anxiety, Depression, and Body Dysmorphic Disorders Among Dermatology Outpatients With Acne Vulgaris at a Public Hospital in Saudi Arabia. Cureus, 16 (7), 64917. https://doi.org/10.7759/cureus.64917
  11. Fox, L., Csongradi, C., Aucamp, M., Du Plessis, J., Gerber, M. (2016). Treatment Modalities for Acne. Molecules, 21 (8), 1063. https://doi.org/10.3390/molecules21081063
  12. Sobkiewicz, P., Józefiak, M., Kania, J., Kania, K., Jędrak, M., Niekurzak, K. (2023). Seborrheic dermatitis – pathogenesis, epidemiology and effective treatment – literature review. Journal of Education, Health and Sport, 38 (1), 230–245. https://doi.org/10.12775/jehs.2023.38.01.016
  13. Shamloul, G., Khachemoune, A. (2021). An updated review of the sebaceous gland and its role in health and diseases Part 1: Embryology, evolution, structure, and function of sebaceous glands. Dermatologic Therapy, 34 (1). https://doi.org/10.1111/dth.14695
  14. Byrd, A. L., Belkaid, Y., Segre, J. A. (2018). The human skin microbiome. Nature Reviews Microbiology, 16 (3), 143–155. https://doi.org/10.1038/nrmicro.2017.157
  15. Mayslich, C., Grange, P. A., Dupin, N. (2021). Cutibacterium acnes as an Opportunistic Pathogen: An Update of Its Virulence-Associated Factors. Microorganisms, 9 (2), 303. https://doi.org/10.3390/microorganisms9020303
  16. Jhawat, V., Gulia, M., Maddiboyina, B., Dutt, R., Gupta, S. (2020). Fate and Applications of Superporous Hydrogel Systems: A Review. Current Nanomedicine, 10 (4), 326–341. https://doi.org/10.2174/2468187310999200819201555
  17. Chauhan, P. N., Sharma, A., Rasheed, H., Mathur, H., Sharma, P. (2023). Treatment Opportunities and Technological Progress Prospective for Acne Vulgaris. Current Drug Delivery, 20 (8), 1037–1048. https://doi.org/10.2174/1567201819666220623154225 stress and antioxidant strategie
  18. Baek, J., Lee, M.-G. (2016). Oxidative s in dermatology. Redox Report, 21(4), 164–169. https://doi.org/10.1179/1351000215y.0000000015
  19. Kurokawa, I., Layton, A. M., Ogawa, R. (2021). Updated Treatment for Acne: Targeted Therapy Based on Pathogenesis. Dermatology and Therapy, 11 (4), 1129–1139. https://doi.org/10.1007/s13555-021-00552-6
  20. Tan, J. K. L., Stein Gold, L. F., Alexis, A. F., Harper, J. C. (2018). Current Concepts in Acne Pathogenesis: Pathways to Inflammation. Seminars in Cutaneous Medicine and Surgery, 37 (3S), S60–S62. https://doi.org/10.12788/j.sder.2018.024
  21. Cui, H., Feng, C., Guo, C., Duan, Z. (2022). Development of Novel Topical Anti-Acne Cream Containing Postbiotics for Mild-to-Moderate Acne. Indian Journal of Dermatology, 67 (6), 667–673. https://doi.org/10.4103/ijd.ijd_655_22
  22. Tobiasz, A., Nowicka, D., Szepietowski, J. C. (2022). Acne Vulgaris–Novel Treatment Options and Factors Affecting Therapy Adherence: A Narrative Review. Journal of Clinical Medicine, 11 (24), 7535. https://doi.org/10.3390/jcm11247535
  23. Shah, N., Shukla, R., Chaudhari, P., Patil, S., Patil, A., Nadkarni, N., Goldust, M. (2021). Prevalence of acne vulgaris and its clinico‐epidemiological pattern in adult patients: Results of a prospective, observational study. Journal of Cosmetic Dermatology, 20 (11), 3672–3678. https://doi.org/10.1111/jocd.14040
  24. Shtrimaitis, O., Kukhtenko, O., Nesteruk, T. (2024). Research of soft dosage forms containing retinoids. Health & Education, 1, 149–154. https://doi.org/10.32782/health-2024.1.20
  25. Sevimli Dikicier, B. (2019). Topical treatment of acne vulgaris: efficiency, side effects, and adherence rate. Journal of International Medical Research, 47 (7), 2987–2992. https://doi.org/10.1177/0300060519847367
  26. Maddiboyina, B., Jhawat, V., Desu, P. K., Gandhi, S., Nakkala, R. K., Singh, S. (2021). Formulation and evaluation of thermosensitive flurbiprofen in situ nano gel for the ocular delivery. Journal of Biomaterials Science, Polymer Edition, 32 (12), 1584–1597. https://doi.org/10.1080/09205063.2021.1927460
  27. Lukić, M., Pantelić, I., Savić, S. D. (2021). Towards Optimal pH of the Skin and Topical Formulations: From the Current State of the Art to Tailored Products. Cosmetics, 8 (3), 69. https://doi.org/10.3390/cosmetics8030069
  28. Han, G., Wu, J. J., Del Rosso, J. Q. (2020). Use of Topical Tazarotene for the Treatment of Acne Vulgaris in Pregnancy: A Literature Review. The Journal of Clinical And Aesthetic Dermatology, 13 (9), E59–E65. Available at: https://pmc.ncbi.nlm.nih.gov/articles/PMC7577328/
  29. Dando, T. M., Wellington, K. (2005). Topical Tazarotene: a review of its use in the treatment of plaque psoriasis. American Journal of Clinical Dermatology, 6 (4), 255–272. https://doi.org/10.2165/00128071-200506040-00006
  30. Bagatin, E., Costa, C. S. (2020). The use of isotretinoin for acne – an update on optimal dosing, surveillance, and adverse effects. Expert Review of Clinical Pharmacology, 13 (8), 885–897. https://doi.org/10.1080/17512433.2020.1796637
  31. Garg, A. K., Maddiboyina, B., Alqarni, M. H. S., Alam, A., Aldawsari, H. M., Rawat, P. et al. (2021). Solubility enhancement, formulation development and antifungal activity of luliconazole niosomal gel-based system. Journal of Biomaterials Science, Polymer Edition, 32 (8), 1009–1023. https://doi.org/10.1080/09205063.2021.1892471
  32. Swallow, M., Fan, R., Cohen, J., Bunick, C. (2022). Antibiotic Resistance Risk with Oral Tetracycline Treatment of Acne Vulgaris. Antibiotics, 11 (8), 1032. https://doi.org/10.3390/antibiotics11081032
  33. Baldwin, H. (2020). Oral Antibiotic Treatment Options for Acne Vulgaris. The Journal of Clinical And Aesthetic Dermatology, 13 (9), 26–32. Available at: https://pubmed.ncbi.nlm.nih.gov/33133338/
  34. Elsaie, M. (2016). Hormonal treatment of acne vulgaris: an update. Clinical, Cosmetic and Investigational Dermatology, 9, 241–248. https://doi.org/10.2147/ccid.s114830
  35. Hassoun, L., Chahal, D., Sivamani, R., Larsen, L. (2016). The use of hormonal agents in the treatment of acne. Seminars in Cutaneous Medicine and Surgery, 35 (2), 68–73. https://doi.org/10.12788/j.sder.2016.027
  36. Moradi Tuchayi, S., Alexander, T., Nadkarni, A., Feldman, S. R. (2016). Interventions to increase adherence to acne treatment. Patient Preference and Adherence, 10, 2091–2096. https://doi.org/10.2147/ppa.s117437
  37. Zhao, J., Wang, Y., Jiang, L., Mu, Y. (2020). The application of skin care product in acne treatment. Dermatologic Therapy, 33 (6). https://doi.org/10.1111/dth.14287
  38. Dessinioti, C., Katsambas, A. (2022). Antibiotics and Antimicrobial Resistance in Acne: Epidemiological Trends and Clinical Practice Considerations. Yale Journal of Biology and Medicine, 95 (4), 429–443. Available at: https://pubmed.ncbi.nlm.nih.gov/36568833/
  39. Zhu, C., Wei, B., Li, Y., Wang, C. (2025). Antibiotic resistance rates in Cutibacterium acnes isolated from patients with acne vulgaris: a systematic review and meta-analysis. Frontiers in Microbiology, 16. https://doi.org/10.3389/fmicb.2025.1565111
  40. El-Shiekh, R. A., Merghany, R. M., Fayez, N., Hassan, M., Bakr, A. F., Eid, O. et al. (2025). Phytochemicals as emerging therapeutics for acne vulgaris: a comprehensive review. Future Journal of Pharmaceutical Sciences, 11 (1). https://doi.org/10.1186/s43094-025-00842-2
  41. Karieva, E. S., Gaipova, N. N., Maksudova, F. Kh. (2020). The utilization of the strategy of mathematical planning of the experiment in the selection of auxiliary substances for a gel based on dry extract «Fitoinflam». International Journal of Pharmaceutical Research, 12 (4), 3968–3973. https://doi.org/10.31838/ijpr/2020.12.04.545
  42. Gaipova, N. N., Tuliaganov, R. T., Karieva, E. S., Nuridullaeva, K. N. (2020). Izuchenie spetcificheskoi aktivnosti i bezvrednosti sukhogo ekstrakta “Fitoinflam”. Infektciia, immunitet i farmakologiia, 4, 39–45.
  43. Yuan, Y., Wang, Y., Xia, J., Liu, H., Liu, J. P., Li, D. et al. (2021). Topical, light-based, and complementary interventions for acne: an overview of systematic reviews. Cochrane Database of Systematic Reviews, 2021 (11). https://doi.org/10.1002/14651858.cd014918
  44. Zhang, Y., Lane, M. E., Moore, D. J. (2020). An Investigation of the Influence of PEG 400 and PEG-6-Caprylic/Capric Glycerides on Dermal Delivery of Niacinamide. Polymers, 12 (12), 2907. https://doi.org/10.3390/polym12122907
  45. Shih, Y.-H., Liu, D., Chen, Y.-C., Liao, M.-H., Lee, W.-R., Shen, S.-C. (2021). Activation of Deoxyribonuclease I by Nicotinamide as a New Strategy to Attenuate Tetracycline-Resistant Biofilms of Cutibacterium acnes. Pharmaceutics, 13 (6), 819. https://doi.org/10.3390/pharmaceutics13060819
  46. Marques, C., Hadjab, F., Porcello, A., Lourenço, K., Scaletta, C., Abdel-Sayed, P., Hirt-Burri, N., Applegate, L. A., Laurent, A. (2024). Mechanistic Insights into the Multiple Functions of Niacinamide: Therapeutic Implications and Cosmeceutical Applications in Functional Skincare Products. Antioxidants, 13 (4), 425. https://doi.org/10.3390/antiox13040425
  47. Akarsu, S., Fetil, E., Yücel, F., Gül, E., Güneş, A. T. (2011). Efficacy of the addition of salicylic acid to clindamycin and benzoyl peroxide combination for acne vulgaris. The Journal of Dermatology, 39 (5), 433–438. https://doi.org/10.1111/j.1346-8138.2011.01405.x
  48. Zheng, Y., Wan, M., Chen, H., Ye, C., Zhao, Y., Yi, J. et al. (2013). Clinical evidence on the efficacy and safety of an antioxidant optimized 1.5% salicylic acid (SA) cream in the treatment of facial acne: an open, baseline‐controlled clinical study. Skin Research and Technology, 19 (2), 125–130. https://doi.org/10.1111/srt.12022
  49. Rozporządzenie Komisji (UE) 2019/1966 z. dnia 27 listopada 2019 r. w sprawie zmiany i sprostowania załączników II, III i V do rozporządzenia Parlamentu Europejskiego i Rady (WE) nr 1223/2009 dotyczącego produktów kosmetycznych (2019). Dziennik Urzędowy Unii Europejskiej.
  50. Hamidpour, R., Hamidpour, S., Hamidpour, M., Shahlari, M. (2013). Camphor (Cinnamomum camphora), a traditional remedy with the history of treating several diseases. International Journal of Case Reports and Images, 4 (2), 86–89. https://doi.org/10.5348/ijcri-2013-02-267-ra-1
  51. Duda-Madej, A., Viscardi, S., Grabarczyk, M., Topola, E., Kozłowska, J., Mączka, W., Wińska, K. (2024). Is Camphor the Future in Supporting Therapy for Skin Infections? Pharmaceuticals, 17 (6), 715. https://doi.org/10.3390/ph17060715
  52. Nurzyńska-Wierdak, R., Pietrasik, D., Walasek-Janusz, M. (2022). Essential Oils in the Treatment of Various Types of Acne – A Review. Plants, 12 (1), 90. https://doi.org/10.3390/plants12010090
  53. OTC Monograph M017 – External Analgesic Drug Products for Over-the-Counter Human Use (2023). U.S. Food and Drug Administration. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/omuf/monographs/OTC%20Monograph_M017-External%20Analgesic%20Drug%20Products%20for%20OTC%20Human%20Use%2005.02.2023.pdf
  54. Cosmetic Ingredient Hotlist (2015). Health Canada. Available at: https://www.canada.ca/content/dam/hc-sc/migration/hc-sc/cps-spc/alt_formats/pdf/cosmet-person/hot-list-critique/hotlist-liste-eng.pdf
  55. Vinardell, M., Mitjans, M. (2017). Lignins and Their Derivatives with Beneficial Effects on Human Health. International Journal of Molecular Sciences, 18 (6), 1219. https://doi.org/10.3390/ijms18061219
  56. Ariyanta, H. A., Santoso, E. B., Suryanegara, L., Arung, E. T., Kusuma, I. W., Azman Mohammad Taib, M. N. et al. (2023). Recent Progress on the Development of lignin as future ingredient biobased cosmetics. Sustainable Chemistry and Pharmacy, 32, 100966. https://doi.org/10.1016/j.scp.2022.100966
  57. Burban, K., Kukhtenko, H., Kriukova, A., Yakovenko, V., Matsiuk, K., Slipchenko, H., Vyshnevska, L. (2023). Research by choice of excipients ingredients of the gel for the therapy of radiation lesions of the skin based on rheological studies. ScienceRise: Pharmaceutical Science, 5 (45), 44–52. https://doi.org/10.15587/2519-4852.2023.290004
  58. Saryanti, D., Setiawan, I., Dayanto, H. H. (2022). Use of CMC Na as Gelling Agent in Nanoemulgel Formulation of Methanol Extract of Sappan Wood (Caesalpinia sappan L). Journal of Tropical Pharmacy and Chemistry, 6 (1), 21–29. https://doi.org/10.25026/jtpc.v6i1.276
  59. Santos, J., Calero, N., Trujillo-Cayado, L. A., Muñoz, J. (2018). Development and characterisation of a continuous phase based on a fumed silica and a green surfactant with emulsion applications. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 555, 351–357. https://doi.org/10.1016/j.colsurfa.2018.07.017
  60. Churadze, L., Chagelishvili, V., Kakhetelidze, M., Iavich, P., Mskhiladze, L. (2021). Study of the possibility of using silicon dioxide, obtained from metal manganese production waste, in the production of cosmetic creams and ointments. Journal Georgian Medical-News, 314, 166–171. Available at: https://pubmed.ncbi.nlm.nih.gov/34248049/
  61. Shettar, A., Shankar, V. K., Ajjarapu, S., Kulkarni, V. I., Repka, M. A., Murthy, S. N. (2021). Development and characterization of Novel topical oil/PEG creams of voriconazole for the treatment of fungal infections. Journal of Drug Delivery Science and Technology, 66, 102928. https://doi.org/10.1016/j.jddst.2021.102928
  62. Zhang, Y., Lane, M. E., Moore, D. J. (2020). An Investigation of the Influence of PEG 400 and PEG-6-Caprylic/Capric Glycerides on Dermal Delivery of Niacinamide. Polymers, 12 (12), 2907. https://doi.org/10.3390/polym12122907
  63. Babahoum, N., Ould Hamou, M. (2021). Characterization and purification of Algerian natural bentonite for pharmaceutical and cosmetic applications. BMC Chemistry, 15 (1). https://doi.org/10.1186/s13065-021-00776-9
  64. Kabdrakhmanova, S. K., Kerimkulova, A. Z., Nauryzova, S. Z., Aryp, K., Shaimardan, E., Kukhareva, A. D. et al. (2025). Bentonite-Based Composites in Medicine: Synthesis, Characterization, and Applications. Journal of Composites Science, 9(6), 310. https://doi.org/10.3390/jcs9060310
  65. G. Sridhar, G. S., A. S. K. Sankar, A. S. K. S., D. Abirami, D. A., D. ArunKumar, D. A., G. Purushothaman, G. P., J. Renu, J. R., S. RubanPrasath, S. R. (2025). A Review on Formulated Herbal cream. International Journal of Pharmaceutical Research and Applications, 10 (4), 482–495. https://doi.org/10.35629/4494-1004482495
  66. Daud, N. S., Akbar, A. J., Nurhikma, E., Karmilah, K. (2018). Formulation of Snail Slime (Achatina Fulica) Anti-Acne Emulgel using Tween 80-Span 80 as Emulsifying and HPMC as Gelling Agent. Borneo Journal of Pharmacy, 1 (2), 64–67. https://doi.org/10.33084/bjop.v1i2.369
  67. Dhanashri, J., Pradnya, G. (2024). Formulation & evalutaion of herbal anti acne cream with antibacterial, anti-inflammatory, and anti-acne activities. World Journal of Pharmaceutical Research, 13 (4), 556–580.
  68. Polly, G., Shashank, T., Palak, G. (2025). Soothing touch: Formulation and analysis of a rejuvenating herbal massage cream. World Journal of Biology Pharmacy and Health Sciences, 23 (2), 255–269. https://doi.org/10.30574/wjbphs.2025.23.2.0598
  69. Kaur, G., Mehta, S. K. (2017). Developments of Polysorbate (Tween) based microemulsions: Preclinical drug delivery, toxicity and antimicrobial applications. International Journal of Pharmaceutics, 529 (1-2), 134–160. https://doi.org/10.1016/j.ijpharm.2017.06.059
  70. Gorjian, H., Mihankhah, P., Khaligh, N. G. (2022). Influence of tween nature and type on physicochemical properties and stability of spearmint essential oil (Mentha spicata L.) stabilized with basil seed mucilage nanoemulsion. Journal of Molecular Liquids, 359, 119379. https://doi.org/10.1016/j.molliq.2022.119379
  71. Sharma, S., Ahmad, U., Akhtar, J., Islam, A., Muazzam Khan, M., Rizvi, N. (2023). The Art and Science of Cosmetics: Understanding the Ingredients. Cosmetic Products and Industry – New Advances and Applications. https://doi.org/10.5772/intechopen.112925
  72. Agredo, P., Rave, M. C., Echeverri, J. D., Romero, D., Salamanca, C. H. (2019). An Evaluation of the Physicochemical Properties of Stabilized Oil-In-Water Emulsions Using Different Cationic Surfactant Blends for Potential Use in the Cosmetic Industry. Cosmetics, 6 (1), 12. https://doi.org/10.3390/cosmetics6010012
  73. Yakub, J., Setyani, W. (2023). Optimization of Stearic Acid and Triethanolamine in The Antibacterial Cream Staphylococcus aureus Ethanol Extract of Papaya Seeds (Carica papaya L.): Factorial Design Method. Journal of Pharmaceutical Sciences and Community, 20 (1), 1–9. https://doi.org/10.24071/jpsc.002396
  74. Kamrani, P., Hedrick, J., Marks, J. G., Zaenglein, A. L. (2024). Petroleum jelly: A comprehensive review of its history, uses, and safety. Journal of the American Academy of Dermatology, 90 (4), 807–813. https://doi.org/10.1016/j.jaad.2023.06.010
  75. Swati, M. K., Tushar, D. L., Priyanka, S. P., Pankaj, T. G., Sharayu, R. B., Manorama, D. Sh. et al. (2024). Formulation and Evaluation of Poly-Herbal Anti-Acne Cream. Tuijin Jishu/Journal of Propulsion Technology, 45 (2), 5428–5438.
  76. Alam, S., Algahtani, M. S., Ahmad, M. Z., Ahmad, J. (2020). Investigation Utilizing the HLB Concept for the Development of Moisturizing Cream and Lotion: In-Vitro Characterization and Stability Evaluation. Cosmetics, 7 (2), 43. https://doi.org/10.3390/cosmetics7020043
  77. Kaur, S., Bains, P. (2023). Silicone in dermatology: An update. Journal of Cutaneous and Aesthetic Surgery, 16 (1), 14–20. https://doi.org/10.4103/jcas.jcas_204_22
  78. Nong, Y., Maloh, J., Natarelli, N., Gunt, H. B., Tristani, E., Sivamani, R. K. (2023). A review of the use of beeswax in skincare. Journal of Cosmetic Dermatology, 22 (8), 2166–2173. https://doi.org/10.1111/jocd.15718
  79. Modarresy, S. Z., Sattarpour, R., Sadeghimoghadam, P., Maleki, F. M., Belar, S., Saniani, A. M. et al. (2025). Efficacy of a Topical Lanolin-Beeswax-Olive Oil Blend (RepoGen Cream) in Preventing Nipple Fissures in Breastfeeding Women: A Randomized Controlled Trial. Journal of Cosmetic Dermatology, 24 (9), 70409. https://doi.org/10.1111/jocd.70409
  80. Vaillant, L., Georgescou, G., Rivollier, C., Delarue, A. (2019). Combined effects of glycerol and petrolatum in an emollient cream: A randomized, double‐blind, crossover study in healthy volunteers with dry skin. Journal of Cosmetic Dermatology, 19 (6), 1399–1403. https://doi.org/10.1111/jocd.13163
  81. Montiel, M. C., Máximo, F., Serrano‐Arnaldos, M., Ortega‐Requena, S., Murcia, M. D., Bastida, J. (2019). Biocatalytic solutions to cyclomethicones problem in cosmetics. Engineering in Life Sciences, 19 (5), 370–388. https://doi.org/10.1002/elsc.201800194
  82. Mawazi, S. M., Ann, J., Othman, N., Khan, J., Alolayan, S. O., Al thagfan, S. S., Kaleemullah, M. (2022). A Review of Moisturizers; History, Preparation, Characterization and Applications. Cosmetics, 9 (3), 61. https://doi.org/10.3390/cosmetics9030061
  83. Raj, H., Sharma, P., Jain, V. (2025). Formulation & Evaluation of Cream of Suhaga & Salicylic Acid for Acne Treatment. Journal of Neonatal Surgery, 14 (18S), 747–758. https://doi.org/10.63682/jns.v14i18s.5256
  84. Sinodukoo, O., Avbunudiogba, J. A., Ochonogor, A., Benedict, B. I., Anie, C. O. (2024). Evaluation of the Physicochemical, Antimicrobial and in vivo Wound Healing Properties of Castor Oil-Loaded Nanogels. Tropical Journal of Natural Product Research, 8 (5), 7292–7300. https://doi.org/10.26538/tjnpr/v8i5.35
  85. Yusuf, S., Nurbik, Kh. (2022). Formulation and Evaluation of Grape Seed Oil (Vitis Vinifera, L) Facial Cream with Variations in The Concentration of Stearic Acid as an Emulsifier. Journal of Health Sciences and Medical Development, 1 (1), 20–30. https://doi.org/10.56741/hesmed.v1i01.32
  86. Shawahna, R. (2022). Effects of a grapeseed oil (Vitis vinifera L.) loaded dermocosmetic nanoemulgel on biophysical parameters of facial skin: A split‐face, blinded, placebo‐controlled study. Journal of Cosmetic Dermatology, 21 (11), 5730–5738. https://doi.org/10.1111/jocd.15161
  87. Mota, A. H., Silva, C. O., Nicolai, M., Baby, A., Palma, L., Rijo, P. et al. (2017). Design and evaluation of novel topical formulation with olive oil as natural functional active. Pharmaceutical Development and Technology, 23 (8), 794–805. https://doi.org/10.1080/10837450.2017.1340951
  88. Abdalla, S., Aroua, M. K., Gew, L. T. (2024). A Comprehensive Review of Plant-Based Cosmetic Oils (Virgin Coconut Oil, Olive Oil, Argan Oil, and Jojoba Oil): Chemical and Biological Properties and Their Cosmeceutical Applications. ACS Omega, 9 (44), 44019–44032. https://doi.org/10.1021/acsomega.4c04277
  89. Goik, U., Goik, T., Załęska, I. (2019). The Properties and Application of Argan Oil in Cosmetology. European Journal of Lipid Science and Technology, 121 (4). https://doi.org/10.1002/ejlt.201800313
  90. Serrafi, A., Chegdani, F., Bennis, F., Kepinska, M. (2024). The Importance of Argan Oil in Medicine and Cosmetology. Nutrients, 16 (20), 3573. https://doi.org/10.3390/nu16203573
  91. Karemore, M. N., Charde, Y. M., Dharmadhikari, P., Bhise, S. M. (2017). Formulation and evaluation of a moisturizing cream using almond butter. International Journal of Pharmaceutical Sciences and Drug Research, 9 (3), 105–112. https://doi.org/10.25004/ijpsdr.2017.090302
  92. Blaak, J., Staib, P. (2022). An updated review on efficacy and benefits of sweet almond, evening primrose and jojoba oils in skin care applications. International Journal of Cosmetic Science, 44 (1), 1–9. https://doi.org/10.1111/ics.12758
  93. Krowczynski, Goawej, L. S. (1984). Badan naukowych w dziedxinie technologii postaci leku (1972–1982). Farmacja Polska, 40 (1), 21–26.
  94. Kiselyova, K., Vyshnevska, L., Yudkevych, T., Bodnar, L., Skybitska, M., Ivanauskas, L. et al. (2025). Development of the composition of a dermatological product in the form of a cream with extracts of the aerial part of lespedeza bicolor. ScienceRise: Pharmaceutical Science, 1 (53), 26–40. https://doi.org/10.15587/2519-4852.2025.322855
Застосування методу математичного планування для підбору допоміжних компонентів для створення лікувально-косметичного засобу функціонального призначення

##submission.downloads##

Опубліковано

2026-02-28

Як цитувати

Karieva, E., Baratova, M., Matazimov, M., & Кухтенко, О. С. (2026). Застосування методу математичного планування для підбору допоміжних компонентів для створення лікувально-косметичного засобу функціонального призначення. ScienceRise: Pharmaceutical Science, (1 (59), 11–21. https://doi.org/10.15587/2519-4852.2026.350751

Номер

№ 1 (59) (2026)

Розділ

Фармацевтичні науки

Ліцензія

Авторське право (c) 2026 Ekut Karieva, Malika Baratova, Mukhammadjon Matazimov, Oleksandr Kukhtenko

Creative Commons License

Ця робота ліцензується відповідно до Creative Commons Attribution 4.0 International License.

Наше видання використовує положення про авторські права Creative Commons CC BY для журналів відкритого доступу.