Review of formulation and evaluation of self-micro emulsifying drug delivery system (SMEDDS)
DOI:
https://doi.org/10.15587/2519-4852.2020.210825Ключові слова:
SMEDDS (self micro emulsifying drug delivery system), GI fluids (gastrointestinal fluids), o/w (oil in water), optimization, Isotropic mixture, X-ray powder diffraction (XPRD), zeta potential, surfactant, co-surfactantАнотація
Approximately half of the new drug applicants that reach formulation have poor water solubility. Oral delivery has been the main route of drug administration for the chronic treatment of numerous diseases. In different cases, in oral conveyance, 50 % of the medication compound is hampered because of the high lipid soluble or fat soluble of the medication itself. Around 40 % of new drug applicants show low solubility in water, which prompts poor oral bioavailability, high Intra and Intersubject changeability, and deficiency of dose proportionality
Aim of review. The main aim of this review article is to gather the information related to design and evaluation of SMEDDS. These information can be utilized to enhance the bioavailability of the poorly aqueous soluble drug for various types of orally administered drugs. In this review article, various literature are reviewed and summerised in single paper to serve as reference guide to various research scholars and researchers working on self-micro-emulsifying drug delivery systems.
Materials and Methods. To prepare this manuscript various keywords were searched in different search engine such as Google, Yahoo and Bing etc. This review article reviews the recent work done in the field of SMEDDS. It comprises review of literatures available in public domain and formulation of SMEDDS and its characterization is summarized in this article.
Result. The various strategies to developed poor aqueous soluble drug for improvement of bioavailability for example, salt development and molecular size reduction of the compound might be one technique to enhance the dissolution rate of the drug. In any case, these methods have their limitations. SMEDDS is one of the novel applications for the delivery of low water soluble and low bioavailability of drug. SMEDDS is a method to improve the aqueous solubility of the medication; SMEDDS are described as isotropic blenders of oils, surfactants, and co-surfactant. Upon slightly stir followed by dilution with distilled water, for example, gastrointestinal liquids, these techniques can define clear o/w micro emulsion. SMEDDS is first choice and key technology for developing the lipophilic drug and other different factors that chance to affect the oral bioavailability.
Conclusions. This review paper attempts to describe the preparation of SMEDDS and furthermore discusses the development of pseudo ternary phase diagram for SMEDDS. It describes the mechanism and method of preparation involved in SMEDDS. The capability of oral absorption of drug compound from the SMEDDS relies upon numerous formulation−related parameters, for example, surfactant concentration, oil/surfactant ratio, and hydrophobicity of emulsion, globule size and charge, in vitro, in vivo all of which basically characterized the ability of self-emulsification. SMEDDS are administered as unit dosage form and it also protect the degradation of drugПосилання
- Maurya, S. D., Arya, R. K., Rajpal, G., Dhakar, R. C. (2017). Self-micro emulsifying drug delivery systems (smedds): a review on physico-chemical and biopharmaceutical aspects. Journal of Drug Delivery and Therapeutics, 7 (3), 55–65. doi: http://doi.org/10.22270/jddt.v7i3.1453
- Ramya, A. R., Sudheer, P., Mohameid, A. S., Das, A. K. (2019). Design and Evaluation of a Self-Emulsifying Drug Delivery System of Aripiprazole. Indian Journal of Pharmaceutical Sciences, 81 (6), 1089–1098. doi: http://doi.org/10.36468/pharmaceutical-sciences.607
- Gumaste, S. G., Freire, B. O. S., Serajuddin, A. T. M. (2017). Development of solid SEDDS, VI: Effect of precoating of Neusilin® US2 with PVP on drug release from adsorbed self-emulsifying lipid-based formulations. European Journal of Pharmaceutical Sciences, 110, 124–133. doi: http://doi.org/10.1016/j.ejps.2017.02.022
- Ramesh, B. J., Ramu, A., Vidyadhara, S., Balakrishna, T. (2019). Design and Evaluation of Telmisartan SMEDDS for Enhancing Solubility and Dissolution Rate. International Journal of Pharmaceutical Sciences and Nanotechnology, 12 (6), 4721–4730. doi: http://doi.org/10.37285/ijpsn.2019.12.6.8
- Patel, M. J., Patel, S. S., Patel, N. M., Patel, M. M. (2010). A self-microemulsifying drug delivery system (SMEDDS). International Journal of Pharmaceutical Sciences Review and Research, 4 (3), 29–35. doi: http://doi.org/10.14843/jpstj.70.32
- Kalamkar, P., Pawar, K., Baddi, H., Thawkar, B., Yevale, R., Kale, M. (2016). A Review on “ Self Micro Emulsifying Drug Delivery System (SMEDDS ). Indian Journal of Drug, 4 (3), 361–373.
- Dokania, S., Joshi, A. K. (2014). Self-microemulsifying drug delivery system (SMEDDS) – challenges and road ahead. Drug Delivery, 22 (6), 675–690. doi: http://doi.org/10.3109/10717544.2014.896058
- Patel, M. H., Sawant, K. K. (2019). Self microemulsifying drug delivery system of lurasidone hydrochloride for enhanced oral bioavailability by lymphatic targeting: In vitro, Caco-2 cell line and in vivo evaluation. European Journal of Pharmaceutical Sciences, 138, 105027. doi: http://doi.org/10.1016/j.ejps.2019.105027
- Aggarwal, G., Harikumar, S., Jaiswal, P., Singh, K. (2014). Development of self-microemulsifying drug delivery system and solid-self-microemulsifying drug delivery system of telmisartan. International Journal of Pharmaceutical Investigation, 4 (4), 195. doi: http://doi.org/10.4103/2230-973x.143123
- Shakeel, F., Raish, M., Anwer, M. K., Al-Shdefat, R. (2016). Self-nanoemulsifying drug delivery system of sinapic acid: In vitro and in vivo evaluation. Journal of Molecular Liquids, 224, 351–358. doi: http://doi.org/10.1016/j.molliq.2016.10.017
- Bolko Seljak, K., Ilić, I. G., Gašperlin, M., Zvonar Pobirk, A. (2018). Self-microemulsifying tablets prepared by direct compression for improved resveratrol delivery. International Journal of Pharmaceutics, 548 (1), 263–275. doi: http://doi.org/10.1016/j.ijpharm.2018.06.065
- Pandit, A., Kedar, A., Koyate, K. (2020). Hollow pessary loaded with lawsone via self-microemulsifying drug delivery system for vaginal candidiasis. Journal of Drug Delivery Science and Technology, 60, 101955. doi: http://doi.org/10.1016/j.jddst.2020.101955
- Reddy, S., Katyayani, T., Navatha, A., Ramya, G. (2011). Review on self micro emulsifying drug delivery systems. International Journal of Research in Pharmaceutical Sciences, 2 (3), 382–392.
- Akiladevi, D. N. M. (2017). Formulation And Development Of Self Emulsifying Drug Delivery System For Few Drugs. International Journal of Pharmacy and Pharmaceutical Sciences, 8 (0975–1491), 1–133.
- Yetukuri, K. S. P. (2012). Yetukuri and Sudheer. Internation Journal of Pharmaceutical Science and Research, 3 (10), 3550–3558.
- Talele, S. G., Gudsoorkar, V. R., Pharmacy, M. V. P. C. (2016). Novel Approaches for Solidification of Smedds. International Journal of pharma and bio sciences, 4, 90–101.
- Patil, A. S., Mahajan, H. D., Wagh, R. D., Deore, B. L., Mali, B. J. (2016). Self-micro emulsifying drug delivery system (SMDDS): a novel approach for enhancement of bioavailability. Pharma Science Monitor, 5 (1), 133–143. Available at: http://www.pharmasm.com/download1.php?articleid=712&download_file=20140320110931_20140123221316_10_amod.pdf
- Shah Sanket, P., Shah Mansi, D. A. Y. (2012). Self- Micro Emulsifying Drug Delivery System: A Novel Approach For Enhancement Of Oral Bioavailability Of Poorly Soluable Drugs. American Journal of PharmTech Research, 2249-3387, 194–215.
- Shi, C.-H., Cai, S., Zhang, X., Tang, xiaojiao, Suo, H., Yang, li, Zhao, Y. (2014). Self-microemulsifying drug-delivery system for improved oral bioavailability of 20(S)-25-methoxyl-dammarane-3beta;, 12beta;, 20-triol: preparation and evaluation. International Journal of Nanomedicine, 9, 913–920. doi: http://doi.org/10.2147/ijn.s56894
- Chaudhari, K. S., Akamanchi, K. G. (2019). Novel bicephalous heterolipid based self-microemulsifying drug delivery system for solubility and bioavailability enhancement of efavirenz. International Journal of Pharmaceutics, 560, 205–218. doi: http://doi.org/10.1016/j.ijpharm.2019.01.065
- Timur, S. S., Yöyen-Ermiş, D., Esendağlı, G., Yonat, S., Horzum, U., Esendağlı, G., Gürsoy, R. N. (2019). Efficacy of a novel LyP-1-containing self-microemulsifying drug delivery system (SMEDDS) for active targeting to breast cancer. European Journal of Pharmaceutics and Biopharmaceutics, 136, 138–146. doi: http://doi.org/10.1016/j.ejpb.2019.01.017
- Huang, W., Su, H., Wen, L., Shao, A., Yang, F., Chen, G. (2018). Enhanced anticancer effect of Brucea javanica oil by solidified self-microemulsifying drug delivery system. Journal of Drug Delivery Science and Technology, 48, 266–273. doi: http://doi.org/10.1016/j.jddst.2018.10.001
- Cirri, M., Roghi, A., Valleri, M., Mura, P. (2016). Development and characterization of fast-dissolving tablet formulations of glyburide based on solid self-microemulsifying systems. European Journal of Pharmaceutics and Biopharmaceutics, 104, 19–29. doi: http://doi.org/10.1016/j.ejpb.2016.04.008
- Janković, J., Djekic, L., Dobričić, V., Primorac, M. (2016). Evaluation of critical formulation parameters in design and differentiation of self-microemulsifying drug delivery systems (SMEDDSs) for oral delivery of aciclovir. International Journal of Pharmaceutics, 497 (1-2), 301–311. doi: http://doi.org/10.1016/j.ijpharm.2015.11.011
- Chintalapudi, R., Murthy, T. E. G. K., Lakshmi, Kr., Manohar, Gg. (2015). Formulation, optimization, and evaluation of self-emulsifying drug delivery systems of nevirapine. International Journal of Pharmaceutical Investigation, 5 (4), 205. doi: http://doi.org/10.4103/2230-973x.167676
- Nardin, I., Köllner, S. (2019). Successful development of oral SEDDS: screening of excipients from the industrial point of view. Advanced Drug Delivery Reviews, 142, 128–140. doi: http://doi.org/10.1016/j.addr.2018.10.014
- Truong, D. H., Tran, T. H., Ramasamy, T., Choi, J. Y., Lee, H. H., Moon, C. et. al. (2015). Development of Solid Self-Emulsifying Formulation for Improving the Oral Bioavailability of Erlotinib. AAPS PharmSciTech, 17 (2), 466–473. doi: http://doi.org/10.1208/s12249-015-0370-5
- Parakh, D. R., Patil, M. P., Sonawane, S. S., Kshirsagar, S. J. (2016). Application of factorial design approach in development and evaluation of self microemulsifying drug delivery system (SMEDDS) of mebendazole. Journal of Pharmaceutical Investigation, 47 (6), 507–519. doi: http://doi.org/10.1007/s40005-016-0279-3
- Sunazuka, Y., Ueda, K., Higashi, K., Tanaka, Y., Moribe, K. (2018). Combined effects of the drug distribution and mucus diffusion properties of self-microemulsifying drug delivery systems on the oral absorption of fenofibrate. International Journal of Pharmaceutics, 546 (1-2), 263–271. doi: http://doi.org/10.1016/j.ijpharm.2018.05.031
- Chou, Y.-C., Li, S., Ho, C.-T., Pan, M.-H. (2020). Preparation and evaluation of self-microemulsifying delivery system containing 5-demethyltangeretin on inhibiting xenograft tumor growth in mice. International Journal of Pharmaceutics, 579, 119134. doi: http://doi.org/10.1016/j.ijpharm.2020.119134
- Zheng, D., Lv, C., Sun, X., Wang, J., Zhao, Z. (2019). Preparation of a supersaturatable self-microemulsion as drug delivery system for ellagic acid and evaluation of its antioxidant activities. Journal of Drug Delivery Science and Technology, 53, 101209. doi: http://doi.org/10.1016/j.jddst.2019.101209
- Jo, K., Kim, H., Khadka, P., Jang, T., Kim, S. J., Hwang, S.-H., Lee, J. (2020). Enhanced intestinal lymphatic absorption of saquinavir through supersaturated self-microemulsifying drug delivery systems. Asian Journal of Pharmaceutical Sciences, 15 (3), 336–346. doi: http://doi.org/10.1016/j.ajps.2018.11.009
- Shete, H., Sable, S., Tidke, P., Selkar, N., Pawar, Y., Chakraborty, A. et. al. (2015). Mono-guanidine heterolipid based SMEDDS: A promising tool for cytosolic delivery of antineoplastics. Biomaterials, 57, 116–132. doi: http://doi.org/10.1016/j.biomaterials.2015.03.040
- Pandey, V., Kohli, S. (2017). SMEDDS of pioglitazone: Formulation, in-vitro evaluation and stability studies. Future Journal of Pharmaceutical Sciences, 3 (1), 53–59. doi: http://doi.org/10.1016/j.fjps.2017.02.003
- Wu, L., Qiao, Y., Wang, L., Guo, J., Wang, G., He, W. et. al. (2015). A Self-microemulsifying Drug Delivery System (SMEDDS) for a Novel Medicative Compound Against Depression: a Preparation and Bioavailability Study in Rats. AAPS PharmSciTech, 16 (5), 1051–1058. doi: http://doi.org/10.1208/s12249-014-0280-y
- Akula, S., Gurram, A. K., Devireddy, S. R. (2014). Self-Microemulsifying Drug Delivery Systems: An Attractive Strategy for Enhanced Therapeutic Profile. International Scholarly Research Notices, 2014, 1–11. doi: http://doi.org/10.1155/2014/964051
- Djekic, L., Janković, J., Rašković, A., Primorac, M. (2018). Semisolid self-microemulsifying drug delivery systems (SMEDDSs): Effects on pharmacokinetics of acyclovir in rats. European Journal of Pharmaceutical Sciences, 121, 287–292. doi: http://doi.org/10.1016/j.ejps.2018.06.005
- Gao, H., Wang, M., Sun, D., Sun, S., Sun, C., Liu, J., Guan, Q. (2017). Evaluation of the cytotoxicity and intestinal absorption of a self-emulsifying drug delivery system containing sodium taurocholate. European Journal of Pharmaceutical Sciences, 106, 212–219. doi: http://doi.org/10.1016/j.ejps.2017.06.005
- Akram, J., Khan, J., Asbi, A., Budiasih, S. (2014). Formulation And Development Of Self Micro- Emulsifying Drug. World Journal of Pharmaceutical Research, 3 (7), 105–124.
- Hintzen, F., Perera, G., Hauptstein, S., Müller, C., Laffleur, F., Bernkop-Schnürch, A. (2014). In vivo evaluation of an oral self-microemulsifying drug delivery system (SMEDDS) for leuprorelin. International Journal of Pharmaceutics, 472 (1-2), 20–26. doi: http://doi.org/10.1016/j.ijpharm.2014.05.047
- Sprunk, A., Strachan, C. J., Graf, A. (2012). Rational formulation development and in vitro assessment of SMEDDS for oral delivery of poorly water soluble drugs. European Journal of Pharmaceutical Sciences, 46 (5), 508–515. doi: http://doi.org/10.1016/j.ejps.2012.04.001
- Rajpoot, K., Tekade, M., Pandey, V., Nagaraja, S., Youngren-Ortiz, S. R., Tekade, R. K. (2020). Self-microemulsifying drug-delivery system: ongoing challenges and future ahead. Drug Delivery Systems. Elsevier Inc., 393–454. doi: http://doi.org/10.1016/b978-0-12-814487-9.00009-0
- Chen, X.-Q., Ziemba, T., Huang, C., Chang, M., Xu, C., Qiao, J. X. et. al. (2018). Oral Delivery of Highly Lipophilic, Poorly Water-Soluble Drugs: Self-Emulsifying Drug Delivery Systems to Improve Oral Absorption and Enable High-Dose Toxicology Studies of a Cholesteryl Ester Transfer Protein Inhibitor in Preclinical Species. Journal of Pharmaceutical Sciences, 107 (5), 1352–1360. doi: http://doi.org/10.1016/j.xphs.2018.01.003
- Tung, N.-T., Tran, C.-S., Pham, T.-M.-H., Nguyen, H.-A., Nguyen, T.-L., Chi, S.-C. et. al. (2018). Development of solidified self-microemulsifying drug delivery systems containing l-tetrahydropalmatine: Design of experiment approach and bioavailability comparison. International Journal of Pharmaceutics, 537 (1-2), 9–21. doi: http://doi.org/10.1016/j.ijpharm.2017.12.027
- Wei, Y., Ye, X., Shang, X., Peng, X., Bao, Q., Liu, M. et. al. (2012). Enhanced oral bioavailability of silybin by a supersaturatable self-emulsifying drug delivery system (S-SEDDS). Colloids and Surfaces A: Physicochemical and Engineering Aspects, 396, 22–28. doi: http://doi.org/10.1016/j.colsurfa.2011.12.025
- Cheng, G., Hu, R., Ye, L., Wang, B., Gui, Y., Gao, S. et. al. (2015). Preparation and In Vitro/In Vivo Evaluation of Puerarin Solid Self-Microemulsifying Drug Delivery System by Spherical Crystallization Technique. AAPS PharmSciTech, 17 (6), 1336–1346. doi: http://doi.org/10.1208/s12249-015-0469-8
- Ujhelyi, Z., Kalantari, A., Vecsernyés, M., Róka, E., Fenyvesi, F., Póka, R. et. al. (2015). The Enhanced Inhibitory Effect of Different Antitumor Agents in Self-Microemulsifying Drug Delivery Systems on Human Cervical Cancer HeLa Cells. Molecules, 20 (7), 13226–13239. doi: http://doi.org/10.3390/molecules200713226
- Yang, S., Gursoy, R. N., Lambert, G., Benita, S. (2004). Enhanced Oral Absorption of Paclitaxel in a Novel Self-Microemulsifying Drug Delivery System with or Without Concomitant Use of P-Glycoprotein Inhibitors. Pharmaceutical Research, 21 (2), 261–270. doi: http://doi.org/10.1023/b:pham.0000016238.44452.f1
- Aswar, M., Bhalekar, M., Trimukhe, A., Aswar, U. (2020). Self-microemulsifying drug delivery system (SMEDDS) of curcumin attenuates depression in olfactory bulbectomized rats. Heliyon, 6 (8), e04482. doi: http://doi.org/10.1016/j.heliyon.2020.e04482
- Visetvichaporn, V., Kim, K.-H., Jung, K., Cho, Y.-S., Kim, D.-D. (2020). Formulation of self-microemulsifying drug delivery system (SMEDDS) by D-optimal mixture design to enhance the oral bioavailability of a new cathepsin K inhibitor (HL235). International Journal of Pharmaceutics, 573, 118772. doi: http://doi.org/10.1016/j.ijpharm.2019.118772
- Gumaste, S. G., Serajuddin, A. T. M. (2017). Development of solid SEDDS, VII: Effect of pore size of silica on drug release from adsorbed self-emulsifying lipid-based formulations. European Journal of Pharmaceutical Sciences, 110, 134–147. doi: http://doi.org/10.1016/j.ejps.2017.05.014
- Prachi, S., Prajapati, S. K. K. S. U., Shipra, S., Ali, A. (2012). a Review on Self Micro Emulsifying Drug Delivery System: an Approach To Enhance the Oral Bioavailability of Poorly Water Soluble Drugs. International Research Journal of Pharmacy, 3 (9), 1–6.
- Sha, X., Wu, J., Chen, Y., Fang, X. (2012). Self-microemulsifying drug-delivery system for improved oral bioavailability of probucol: Preparation and evaluation. International Journal of Nanomedicine, 7, 705–712. doi: http://doi.org/10.2147/ijn.s28052
- Joyce, P., Dening, T. J., Meola, T. R., Schultz, H. B., Holm, R., Thomas, N., Prestidge, C. A. (2019). Solidification to improve the biopharmaceutical performance of SEDDS: Opportunities and challenges. Advanced Drug Delivery Reviews, 142, 102–117. doi: http://doi.org/10.1016/j.addr.2018.11.006
- Goyal, U., Gupta, A., Rana, A. C., Aggarwal, G. (2012). Self microemulsifying drug delivery system: A method for enhancement of bioavailability. International Journal of Pharmaceutical Sciences, 3 (1), 66–79.
- Milović, M., Djuriš, J., Djekić, L., Vasiljević, D., Ibrić, S. (2012). Characterization and evaluation of solid self-microemulsifying drug delivery systems with porous carriers as systems for improved carbamazepine release. International Journal of Pharmaceutics, 436 (1-2), 58–65. doi: http://doi.org/10.1016/j.ijpharm.2012.06.032
- Hyma, P., Abbulu, K. (2013). Formulation and characterisation of self-microemulsifying drug delivery system of pioglitazone. Biomedicine & Preventive Nutrition, 3 (4), 345–350. doi: http://doi.org/10.1016/j.bionut.2013.09.005
- Chen, X.-Q., Ziemba, T., Huang, C., Chang, M., Xu, C., Qiao, J. X. et. al. (2018). Oral Delivery of Highly Lipophilic, Poorly Water-Soluble Drugs: Self-Emulsifying Drug Delivery Systems to Improve Oral Absorption and Enable High-Dose Toxicology Studies of a Cholesteryl Ester Transfer Protein Inhibitor in Preclinical Species. Journal of Pharmaceutical Sciences, 107 (5), 1352–1360. doi: http://doi.org/10.1016/j.xphs.2018.01.003
- Shahnaz, G., Hartl, M., Barthelmes, J., Leithner, K., Sarti, F., Hintzen, F. et. al. (2011). Uptake of phenothiazines by the harvested chylomicrons ex vivo model: Influence of self-nanoemulsifying formulation design. European Journal of Pharmaceutics and Biopharmaceutics, 79 (1), 171–180. doi: http://doi.org/10.1016/j.ejpb.2011.01.025
- McConville, C., Friend, D. (2013). Development and characterisation of a self-microemulsifying drug delivery systems (SMEDDSs) for the vaginal administration of the antiretroviral UC-781. European Journal of Pharmaceutics and Biopharmaceutics, 83 (3), 322–329. doi: http://doi.org/10.1016/j.ejpb.2012.10.007
- Qureshi, M. J., Mallikarjun, C., Kian, W. G. (2015). Enhancement of solubility and therapeutic potential of poorly soluble lovastatin by SMEDDS formulation adsorbed on directly compressed spray dried magnesium aluminometasilicate liquid loadable tablets: A study in diet induced hyperlipidemic rabbits. Asian Journal of Pharmaceutical Sciences, 10 (1), 40–56. doi: http://doi.org/10.1016/j.ajps.2014.08.003
- Gu, M., Gong, M., Qian, Y., Yan, G. (2013). Development of a self-microemulsifying drug delivery system to enhance oral bioavailability of β-elemene in rats. Journal of Drug Delivery Science and Technology, 23 (5), 485–491. doi: http://doi.org/10.1016/s1773-2247(13)50070-0
- Niederquell, A., Völker, A. C., Kuentz, M. (2012). Introduction of diffusing wave spectroscopy to study self-emulsifying drug delivery systems with respect to liquid filling of capsules. International Journal of Pharmaceutics, 426 (1-2), 144–152. doi: http://doi.org/10.1016/j.ijpharm.2012.01.042
- Abdulkarim, M., Sharma, P. K., Gumbleton, M. (2019). Self-emulsifying drug delivery system: Mucus permeation and innovative quantification technologies. Advanced Drug Delivery Reviews, 142, 62–74. doi: http://doi.org/10.1016/j.addr.2019.04.001
- Djekic, L., Jankovic, J., Čalija, B., Primorac, M. (2017). Development of semisolid self-microemulsifying drug delivery systems (SMEDDSs) filled in hard capsules for oral delivery of aciclovir. International Journal of Pharmaceutics, 528 (1-2), 372–380. doi: http://doi.org/10.1016/j.ijpharm.2017.06.028
- Čerpnjak, K., Pobirk, A. Z., Vrečer, F., Gašperlin, M. (2015). Tablets and minitablets prepared from spray-dried SMEDDS containing naproxen. International Journal of Pharmaceutics, 495 (1), 336–346. doi: http://doi.org/10.1016/j.ijpharm.2015.08.099
- Li, Q., Zhai, W., Jiang, Q., Huang, R., Liu, L., Dai, J. et. al. (2015). Curcumin–piperine mixtures in self-microemulsifying drug delivery system for ulcerative colitis therapy. International Journal of Pharmaceutics, 490 (1-2), 22–31. doi: http://doi.org/10.1016/j.ijpharm.2015.05.008
- Krstić, M., Popović, M., Dobričić, V., Ibrić, S. (2015). Influence of Solid Drug Delivery System Formulation on Poorly Water-Soluble Drug Dissolution and Permeability. Molecules, 20 (8), 14684–14698. doi: http://doi.org/10.3390/molecules200814684
- Shanmugam, S., Im, H. T., Sohn, Y. T., Kim, Y.-I., Park, J.-H., Park, E.-S., Woo, J. S. (2015). Enhanced oral bioavailability of paclitaxel by solid dispersion granulation. Drug Development and Industrial Pharmacy, 41 (11), 1864–1876. doi: http://doi.org/10.3109/03639045.2015.1018275
- Kanwal, T., Kawish, M., Maharjan, R., Ghaffar, I., Ali, H. S., Imran, M. et. al. (2019). Design and development of permeation enhancer containing self-nanoemulsifying drug delivery system (SNEDDS) for ceftriaxone sodium improved oral pharmacokinetics. Journal of Molecular Liquids, 289, 111098. doi: http://doi.org/10.1016/j.molliq.2019.111098
- Kumar, R., Khursheed, R., Kumar, R., Awasthi, A., Sharma, N., Khurana, S. et. al. (2019). Self-nanoemulsifying drug delivery system of fisetin: Formulation, optimization, characterization and cytotoxicity assessment. Journal of Drug Delivery Science and Technology, 54, 101252. doi: http://doi.org/10.1016/j.jddst.2019.101252
- Čerpnjak, K., Zvonar, A., Vrečer, F., Gašperlin, M. (2015). Characterization of naproxen-loaded solid SMEDDSs prepared by spray drying: The effect of the polysaccharide carrier and naproxen concentration. International Journal of Pharmaceutics, 485 (1-2), 215–228. doi: http://doi.org/10.1016/j.ijpharm.2015.03.015
- Garg, V., Kaur, P., Singh, S. K., Kumar, B., Bawa, P., Gulati, M., Yadav, A. K. (2017). Solid self-nanoemulsifying drug delivery systems for oral delivery of polypeptide-k: Formulation, optimization, in-vitro and in-vivo antidiabetic evaluation. European Journal of Pharmaceutical Sciences, 109, 297–315. doi: http://doi.org/10.1016/j.ejps.2017.08.022
- Gupta, S., Chavhan, S., Sawant, K. K. (2011). Self-nanoemulsifying drug delivery system for adefovir dipivoxil: Design, characterization, in vitro and ex vivo evaluation. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 392 (1), 145–155. doi: http://doi.org/10.1016/j.colsurfa.2011.09.048
- Kumar, B., Garg, V., Singh, S., Pandey, N. K., Bhatia, A., Prakash, T. et. al. (2018). Impact of spray drying over conventional surface adsorption technique for improvement in micromeritic and biopharmaceutical characteristics of self-nanoemulsifying powder loaded with two lipophilic as well as gastrointestinal labile drugs. Powder Technology, 326, 425–442. doi: http://doi.org/10.1016/j.powtec.2017.12.005
- Silva, L. A. D., Almeida, S. L., Alonso, E. C. P., Rocha, P. B. R., Martins, F. T., Freitas, L. A. P. et. al. (2018). Preparation of a solid self-microemulsifying drug delivery system by hot-melt extrusion. International Journal of Pharmaceutics, 541 (1-2), 1–10. doi: http://doi.org/10.1016/j.ijpharm.2018.02.020
- Parmar, N., Singla, N., Amin, S., Kohli, K. (2011). Study of cosurfactant effect on nanoemulsifying area and development of lercanidipine loaded (SNEDDS) self nanoemulsifying drug delivery system. Colloids and Surfaces B: Biointerfaces, 86 (2), 327–338. doi: http://doi.org/10.1016/j.colsurfb.2011.04.016
- Inugala, S., Eedara, B. B., Sunkavalli, S., Dhurke, R., Kandadi, P., Jukanti, R., Bandari, S. (2015). Solid self-nanoemulsifying drug delivery system (S-SNEDDS) of darunavir for improved dissolution and oral bioavailability: In vitro and in vivo evaluation. European Journal of Pharmaceutical Sciences, 74, 1–10. doi: http://doi.org/10.1016/j.ejps.2015.03.024
- Shakeel, F., Raish, M., Anwer, M. K., Al-Shdefat, R. (2016). Self-nanoemulsifying drug delivery system of sinapic acid: In vitro and in vivo evaluation. Journal of Molecular Liquids, 224, 351–358. doi: http://doi.org/10.1016/j.molliq.2016.10.017
- Kuentz, M. (2011). Oral self-emulsifying drug delivery systems, from biopharmaceutical to technical formulation aspects. Journal of Drug Delivery Science and Technology, 21 (1), 17–26. doi: http://doi.org/10.1016/s1773-2247(11)50002-4
- Kalam, M. A., Raish, M., Ahmed, A., Alkharfy, K. M., Mohsin, K., Alshamsan, A. et. al. (2017). Oral bioavailability enhancement and hepatoprotective effects of thymoquinone by self-nanoemulsifying drug delivery system. Materials Science and Engineering: C, 76, 319–329. doi: http://doi.org/10.1016/j.msec.2017.03.088
- Aloisio, C., Bueno, M. S., Ponte, M. P., Paredes, A., Palma, S. D., Longhi, M. (2019). Development of solid self-emulsifying drug delivery systems (SEDDS) to improve the solubility of resveratrol. Therapeutic Delivery, 10 (10), 626–641. doi: http://doi.org/10.4155/tde-2019-0054
- Balata, G., Eassa, E., Shamrool, H., Zidan, S., Abdo Rehab, M. (2016). Self-emulsifying drug delivery systems as a tool to improve solubility and bioavailability of resveratrol. Drug Design, Development and Therapy, 10, 117–128. doi: http://doi.org/10.2147/dddt.s95905
- Dhumal, D. M., Akamanchi, K. G. (2018). Self-microemulsifying drug delivery system for camptothecin using new bicephalous heterolipid with tertiary-amine as branching element. International Journal of Pharmaceutics, 541 (1-2), 48–55. doi: http://doi.org/10.1016/j.ijpharm.2018.02.030
- Mekjaruskul, C., Yang, Y.-T., Leed, M. G. D., Sadgrove, M. P., Jay, M., Sripanidkulchai, B. (2013). Novel formulation strategies for enhancing oral delivery of methoxyflavones in Kaempferia parviflora by SMEDDS or complexation with 2-hydroxypropyl-β-cyclodextrin. International Journal of Pharmaceutics, 445 (1-2), 1–11. doi: http://doi.org/10.1016/j.ijpharm.2013.01.052
- Kheawfu, K., Pikulkaew, S., Rades, T., Müllertz, A., Okonogi, S. (2018). Development and characterization of clove oil nanoemulsions and self-microemulsifying drug delivery systems. Journal of Drug Delivery Science and Technology, 46, 330–338. doi: http://doi.org/10.1016/j.jddst.2018.05.028
- Ishak, R. A. H., Osman, R. (2015). Lecithin/TPGS-based spray-dried self-microemulsifying drug delivery systems: In vitro pulmonary deposition and cytotoxicity. International Journal of Pharmaceutics, 485 (1-2), 249–260. doi: http://doi.org/10.1016/j.ijpharm.2015.03.019
- Vasconcelos, T., Marques, S., Sarmento, B. (2018). Measuring the emulsification dynamics and stability of self-emulsifying drug delivery systems. European Journal of Pharmaceutics and Biopharmaceutics, 123, 1–8. doi: http://doi.org/10.1016/j.ejpb.2017.11.003
- Christiansen, M. L., Holm, R., Abrahamsson, B., Jacobsen, J., Kristensen, J., Andersen, J. R., Müllertz, A. (2016). Effect of food intake and co-administration of placebo self-nanoemulsifying drug delivery systems on the absorption of cinnarizine in healthy human volunteers. European Journal of Pharmaceutical Sciences, 84, 77–82. doi: http://doi.org/10.1016/j.ejps.2016.01.011
- Kauss, T., Gaubert, A., Tabaran, L., Tonelli, G., Phoeung, T., Langlois, M.-H. et. al. (2018). Development of rectal self-emulsifying suspension of a moisture-labile water-soluble drug. International Journal of Pharmaceutics, 536 (1), 283–291. doi: http://doi.org/10.1016/j.ijpharm.2017.11.067
- Kadu, P. J., Kushare, S. S., Thacker, D. D., Gattani, S. G. (2010). Enhancement of oral bioavailability of atorvastatin calcium by self-emulsifying drug delivery systems (SEDDS). Pharmaceutical Development and Technology, 16 (1), 65–74. doi: http://doi.org/10.3109/10837450903499333
- Baghel, P., Roy, A., Verma, S., Satapathy, T., Bahadur, S. (2020). Amelioration of lipophilic compounds in regards to bioavailability as self-emulsifying drug delivery system (SEDDS). Future Journal of Pharmaceutical Sciences, 6 (1). doi: http://doi.org/10.1186/s43094-020-00042-0
- Yi, T., Wan, J., Xu, H., Yang, X. (2008). A new solid self-microemulsifying formulation prepared by spray-drying to improve the oral bioavailability of poorly water soluble drugs. European Journal of Pharmaceutics and Biopharmaceutics, 70 (2), 439–444. doi: http://doi.org/10.1016/j.ejpb.2008.05.001
- Patel, D., Sawant, K. K. (2007). Oral Bioavailability Enhancement of Acyclovir by Self-Microemulsifying Drug Delivery Systems (SMEDDS). Drug Development and Industrial Pharmacy, 33 (12), 1318–1326. doi: http://doi.org/10.1080/03639040701385527
- Shen, H., Zhong, M. (2006). Preparation and evaluation of self-microemulsifying drug delivery systems (SMEDDS) containing atorvastatin. Journal of Pharmacy and Pharmacology, 58 (9), 1183–1191. doi: http://doi.org/10.1211/jpp.58.9.0004
- Singh, A. K., Chaurasiya, A., Awasthi, A., Mishra, G., Asati, D., Khar, R. K., Mukherjee, R. (2009). Oral Bioavailability Enhancement of Exemestane from Self-Microemulsifying Drug Delivery System (SMEDDS). AAPS PharmSciTech, 10 (3), 906–916. doi: http://doi.org/10.1208/s12249-009-9281-7
- Truong, D. H., Tran, T. H., Ramasamy, T., Choi, J. Y., Lee, H. H., Moon, C. et. al. (2015). Development of Solid Self-Emulsifying Formulation for Improving the Oral Bioavailability of Erlotinib. AAPS PharmSciTech, 17 (2), 466–473. doi: http://doi.org/10.1208/s12249-015-0370-5
- Xu, Y., Wang, Q., Feng, Y., Firempong, C. K., Zhu, Y., Omari-Siaw, E. et. al. (2016). Enhanced oral bioavailability of [6]-Gingerol-SMEDDS: Preparation, in vitro and in vivo evaluation. Journal of Functional Foods, 27, 703–710. doi: http://doi.org/10.1016/j.jff.2016.10.007
- Mahmood, A., Bernkop-Schnürch, A. (2019). SEDDS: A game changing approach for the oral administration of hydrophilic macromolecular drugs. Advanced Drug Delivery Reviews, 142, 91–101. doi: http://doi.org/10.1016/j.addr.2018.07.001
- Kazi, M., Al-Swairi, M., Ahmad, A., Raish, M., Alanazi, F. K., Badran, M. M. et. al. (2019). Evaluation of Self-Nanoemulsifying Drug Delivery Systems (SNEDDS) for Poorly Water-Soluble Talinolol: Preparation, in vitro and in vivo Assessment. Frontiers in Pharmacology, 10. doi: http://doi.org/10.3389/fphar.2019.00459
- Peltier, S., Oger, J.-M., Lagarce, F., Couet, W., Benoît, J.-P. (2006). Enhanced Oral Paclitaxel Bioavailability After Administration of Paclitaxel-Loaded Lipid Nanocapsules. Pharmaceutical Research, 23 (6), 1243–1250. doi: http://doi.org/10.1007/s11095-006-0022-2
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