An overview on various types of gastroretentive drug delivery system

Автор(и)

  • Sanjib Bahadur Columbia Institute of Pharmacy Vill. Tekari, Near Vidhan Sabha, Raipur, Chhattisgarh, India, 493111, Індія
  • Sahu Manisha Columbia Institute of Pharmacy Vill. Tekari, Near Vidhan Sabha, Raipur, Chhattisgarh, India, 493111, Україна https://orcid.org/0000-0002-9146-3558
  • Pragya Baghel Columbia Institute of Pharmacy Vill. Tekari, Near Vidhan Sabha, Raipur, Chhattisgarh, India, 493111, Україна
  • Kamesh Yadu Columbia Institute of Pharmacy Vill. Tekari, Near Vidhan Sabha, Raipur, Chhattisgarh, India, 493111, Україна https://orcid.org/0000-0003-3126-8803
  • Tripti Naurange Columbia Institute of Pharmacy Vill. Tekari, Near Vidhan Sabha, Raipur, Chhattisgarh, India, 493111, Україна https://orcid.org/0000-0001-9716-4041

DOI:

https://doi.org/10.15587/2519-4852.2020.211931

Ключові слова:

gastric emptying, gastro retentive drug delivery system (GRDSs), floating drug delivery system, biomucoadhesive system

Анотація

Gastro retentive drug delivery system is one of the approaches to achieve controlled drug delivery. The gastro retentive drug delivery system is a way to prolong residence time of active pharmaceutical ingredient in gastrointestinal tract. It is also applied for targeting drug in upper gastrointestinal tract for generating local and systemic effect. Controlled drug delivery creates a window of absorption that release drug for a longer duration of time before reaching absorption site. Gastro retentive drug delivery systems have gained wide variation of oral drug distribution in the area of late. It includes all the approaches that keep the dosage form in the stomach for a longer duration of time. This also enables sustained release of active pharmaceutical ingredient which in turn overcomes many limitations of conventional drug delivery systems. It has begun tremendous advances in the field of gastro-retention to meet controlled release of drugs.

Aim of research. The main aim of this survey to prolong the gastric retention dosage form in the stomach and improve the medication concentration in the stomach.

Material and Method. To prepare this manuscript, various keywords were searched in different search engines such as Google, Yahoo, Bing etc. The available information in public domain was collected and classified according to delivery system. This review paper aim to provide complete information about different delivery systems related to Gastro retentive drug delivery systems (GRDDS). It is also applied for targeting drug in upper gastrointestinal tract for generating local and systemic effect.

Result. After going through various literatures, it can be said that the GRDDS can improve local bioavailability and therapeutic efficacy and dosing frequency possible reduction in dose size. This paper is focused on various physiological contemplation and obtainable formulation approaches for development of gastro retentive drug delivery system.

Conclusions. This article discusses various types of GRDDS and their approaches. The gastric retentive drug delivery systems improve drug absorption. Prolonged gastric retention time of therapeutic mutations provide several benefits such as improving absorption, bioavailability and enhance the therapeutic action of drug

Біографії авторів

Sanjib Bahadur, Columbia Institute of Pharmacy Vill. Tekari, Near Vidhan Sabha, Raipur, Chhattisgarh, India, 493111

PhD, Associate Professor

Department of Pharmaceutics

Sahu Manisha, Columbia Institute of Pharmacy Vill. Tekari, Near Vidhan Sabha, Raipur, Chhattisgarh, India, 493111

Department of Pharmaceutics

Pragya Baghel, Columbia Institute of Pharmacy Vill. Tekari, Near Vidhan Sabha, Raipur, Chhattisgarh, India, 493111

PhD, Assistant Professor

Department of Pharmaceutics

Kamesh Yadu, Columbia Institute of Pharmacy Vill. Tekari, Near Vidhan Sabha, Raipur, Chhattisgarh, India, 493111

Department of Pharmaceutics

Tripti Naurange, Columbia Institute of Pharmacy Vill. Tekari, Near Vidhan Sabha, Raipur, Chhattisgarh, India, 493111

M. Pharm Student

Department of Pharmaceutics

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Опубліковано

2020-12-30

Як цитувати

Bahadur, S., Manisha, S., Baghel, P., Yadu, K., & Naurange, T. (2020). An overview on various types of gastroretentive drug delivery system. ScienceRise: Pharmaceutical Science, (6 (28), 4–13. https://doi.org/10.15587/2519-4852.2020.211931

Номер

№ 6 (28) (2020)

Розділ

Фармацевтичні науки

Ліцензія

Авторське право (c) 2020 Sanjib Bahadur, Sahu Manisha, Pragya Baghel, Kamesh Yadu, Tripti Naurange

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