Похідні дихлорооцтової кислоти як потенційні протипухлинні та протизапальні агенти

Автор(и)

  • Любомир Михайлович Гаврищук Івано-Франківський національний медичний університет, Україна https://orcid.org/0000-0002-2261-5474
  • Володимир Ярославович Горішній Львівський національний медичний університет імені Данила Галицького, Україна https://orcid.org/0000-0002-5497-6485
  • Надія Іванівна Рущак Івано-Франківський національний медичний університет, Україна http://orcid.org/0000-0003-1050-2613
  • Роман Богданович Лесик University of Information Technology and Management in Rzeszow; Львівський національний медичний університет імені Данила Галицького, Україна

DOI:

https://doi.org/10.15587/2519-4852.2024.299229

Ключові слова:

дихлороацетат, дихлорооцтова кислота, дихлороацетамід, гібридні молекули, протипухлинна активність, протизапальна активність, холестерин, пухлини, апоптоз, хіміотерапія

Анотація

Мета. Метою даного огляду є надання всебічного розуміння похідних дихлорооцтової кислоти. Ми маємо на меті охопити всі аспекти цих сполук, включаючи їхні хімічні властивості, різні методи синтезу та їхнє широке застосування в медичній хімії. Через дослідження їхньої різноманітної ролі у розробці ліків, ми прагнемо підкреслити їх значення та потенціал у формуванні майбутніх фармацевтичних інновацій.

Матеріали та методи. У дослідженні застосовано бібліосемантичний та аналітичний методи.

Результати. Наші дослідження підтверджують потенційну ефективність дихлорооцтової кислоти та її похідних в лікуванні раку та інших захворювань. Ці сполуки виявилися здатними індукувати процес апоптозу, що є програмованою смертю клітин, та пригнічувати ріст ракових клітин. Це особливо ефективно, коли дихлорооцтова кислота та її похідні використовуються в поєднанні з іншими терапевтичними методами, як вказано в патентах, що були наведені в нашому дослідженні. Дихлорооцтова кислота та її похідні також показали здатність знижувати рівень глюкози та холестерину у крові. Це вказує на можливість їх застосування для лікування цукрового діабету, гіперліпідемії, та лактоацидозу. Цукровий діабет, гіперліпідемія та лактоацидоз – це серйозні стани, які можуть призвести до значних проблем зі здоров’ям. Тому можливість використання дихлорооцтової кислоти та її похідних для лікування цих станів відкриває нові перспективи в медичній науці.

Висновки. Наші висновки вказують на перспективи подальших досліджень в галузі розробки нових методів терапії та використання похідних дихлорооцтової кислоти як потенційних лікарських засобів для покращення ефективності лікування раку та інших захворювань. Ми вважаємо, що ці сполуки мають великий потенціал для подальшого вивчення та можуть відіграти важливу роль у майбутніх медичних інноваціях

Біографії авторів

Любомир Михайлович Гаврищук, Івано-Франківський національний медичний університет

Асистент

Кафедра хімії, фармацевтичного аналізу та післядипломної освіти

Володимир Ярославович Горішній, Львівський національний медичний університет імені Данила Галицького

Кандидат фармацевтичних наук, доцент

Кафедра фармацевтичної, органічної і біоорганічної хімії

Надія Іванівна Рущак, Івано-Франківський національний медичний університет

Асистент

Кафедра хімії, фармацевтичного аналізу та післядипломної освіти

Роман Богданович Лесик, University of Information Technology and Management in Rzeszow; Львівський національний медичний університет імені Данила Галицького

Доктор фармацевтичних наук, професор, завідувач кафедри

Кафедра фармацевтичної, органічної і біоорганічної хімії

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Похідні дихлорооцтової кислоти як потенційні протипухлинні та протизапальні агенти

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2024-02-29

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Гаврищук, Л. М., Горішній, В. Я., Рущак, Н. І., & Лесик, Р. Б. (2024). Похідні дихлорооцтової кислоти як потенційні протипухлинні та протизапальні агенти. ScienceRise: Pharmaceutical Science, (1(47), 60–78. https://doi.org/10.15587/2519-4852.2024.299229

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