The value of the dynamics some interleukins of blood serum in patients with multiresystance relapse pulmonary tuberculosis
Keywords:
multidrug-resistant tuberculosis, recurrent tuberculosis, newly diagnosed tuberculosis, immunity, cytokines, interleukin.Abstract
The study of interleukin (IL)-2, IL-4 and IL-8 in 140 patients with pulmonary tuberculosis and 30 healthy donors. In patients with pulmonary tuberculosis before treatment was an increase levels of IL-2, IL-8 and decrease IL-4 compared to the relatively healthy donors. After two-month standard antimycobacterial therapy found significant decrease IL-2, IL-8 and increase IL-4 in patients with pulmonary tuberculosis. More significant changes were expressed as before treatment so after two months of chemotherapy were observed in patients with pulmonary multirezystent pulmonary
tuberculosis, especially in patients with recurrent process than patients without the multirezystent pulmonary tuberculosis and newly diagnosed pulmonary tuberculosis.
References
Global tuberculosis control [Text]: WHO report 2011/ World Health Organization. – Geneva, Switzerland 2011. – 73 p.
The global burden of disease: 2004 update [Text]: Document. W 74. / World Health Organization. – Geneva, Switzerland, 2008 – 146 p.
Multidrug-resistant and extensively drug-resistant tuberculosis: a threat to global control of tuberculosis [Text] / N.R. Gandhi [et al.] // Lancet. – 2010. – №375. – Р.1830–1843.
World Health Organization (2012) Global Tuberculosis Report 2012 [Electronic resource]/ Electronic access: http://apps.who.int/iris/bitstream/10665/75938/1/978924
_eng.pdf.
Analytical view on a problem of drug-resistant tuberculosis: current status, achievements and unsolved issues [Text] / Melnyk V.M., Novozhylova I.O., Matusevych V.G., Linnyk M.I. // Ukrainian pulmonol.
J. – 2012. – №1. – Р. 5-7.
Sokolov G. Clinical and radiological and bacteriological characteristics of drug-resistant tuberculosis [Text] / G. Sokolov, I. Bogadelnikova, M. Biron //Problems of Tuberculosis and Lung Disease. – 2006. – №12. – Р.16-20.
Caminero J.A. Multidrug-resistant tuberculosis: epidemiology, risk factor and case finding [Text] / J.A. Caminero // Int. J. Tuberc. Lung Dis. – 2010. – Vol. 14, №4 – Р.382-390.
Modern features of recurrence of pulmonary tuberculosis in Ukraine [Text] / L.M. Protsyk, M.M. Kuzhko, Y.N. Valetsky, L.A. Grischuk // XXI National Congress on Respiratory Diseases. - Ufa, 25 - 28 October 2011. – Р. 512.
Major risk factors for recurrence of tuberculosis in Poltava region [Text] / A. G. Yareshko, M.G. Boyko, M.V. Kulish, V.G. Bondarenko, A.K. Vorodyuhina // Tuberculosis, pulmonary disease, HIV infection. - 2013. - №4. - P. 55-58.
Tuberculosis in Ukraine (analytical and statistical handbook for 2000-2011) [Text] / Ministry of Health Ukraine. - Kyiv, 2012. - 98 p.
Evaluation of treatment of patients with newly diagnosed pulmonary tuberculosis and recurrent disease indicators for cohort analysis [Text] / V.M. Petrenko, S.O. Cherenko, N.A. Litvinenko, L.M. Tsygankova // Ukrainian pulmonol. J. - 2011. - №3. - P. 5-9.
Aref'eva E.V. Socio-hygienic study of the causes and factors of recurrence of tuberculosis, according to monitoring in the Russian Federation [Text]: dis. … candidate medical sciences: 14.00.33 / Aref'eva Elina Viktorovna. – Moscow, 2008. – 131 p.
The most significant recurrence of pulmonary tuberculosis [Text] / M.M. Kuzhko [et al.] / / Infectious diseases. – 2012. – № 3. – P. 91-94.
Analysis of the impact the effectiveness of basic chemotherapy of newly diagnosed pulmonary tuberculosis on the occurrence of relapses [Text] / M.M. Kuzhko [et al.] // Ukr. Journal of Chemotherapy. –
– № 1-2 (25). – P. 56-61.
Cytokines in the evaluation of the immune system in patients with pulmonary tuberculosis [Text] / E.F. Tchernushenko [et al.] // Ukrainian pulmonol. J. – 2010. – №2. – P.39-43.
Tchernushenko E.F. Antituberculous immunity (Part 1) [Text] / E.F. Tchernushenko, R.G. Protsjuk // Ukrainian pulmonol. J. – 2010. – №4. – P.53-58.
Tchernushenko E.F. Antituberculous immunity (Part 2) [Text] / E.F. Tchernushenko, R.G. Protsjuk // Ukrainian pulmonol. J. – 2011. – №1. – P.29-32.
Detection of interleukin-2 in addition to interferongamma discriminates active tuberculosis patients, latently infected individuals, and controls [Text] / R. Biselli , S. Mariotti, V. Sargentini [at al.] // Clin. Microbiol. Infect. – 2010. – №16(8). – P.1282-1284.
Wu B. Messenger RNA expression of IL-8, FOXP3, and IL-12beta differentiates latent tuberculosis infection from disease [Text] / B. Wu , C. Huang , Kato-M. Maeda // J. Immunol. – 2007 – N178(6). – P. 3688- 3694.
Guo P. Immunotherapy for tuberculosis: what's the better choice? [Text] / S. Guo, J. Zhao// Front Biosci Landmark Ed. – 2012. – №1 (17). – P. 2684-2690.
Increased specific T cell cytokine responses in patients with active pulmonary tuberculosis from Central Africa [Text] / S. Winkler, M. Necek, H. Winkler [et al.] // Microbes Infect. – 2005. – №7. –
Р.1161-1169.
High levels of intracellular IL-4 are expressed in circulating apoptotic T cells in patients with tuberculosis and in community controls [Text] / H. Veenstra, R. Baumann, P.T. Lukey [et al.] // Tuberculosis (Edinb). – 2008. – Vol. 88, №1. – Р.21-30.
Serum concentrations of cytokines in patients with active tuberculosis (TB) and after treatment [Text] / A. Verbon, N. Juffermans, S.J. Van Deventer [et al.] // Clin. Exp. Immunol. – 1999. – Vol. 115, №1. – Р. 110– 113.
Immunosuppression during active tuberculosis is characterized by decreased interferon- gamma production and CD25 expression with elevated forkhead box P3, transforming growth factor- beta , and interleukin-4 mRNA levels [Text] / T. Roberts, N. Beyers, A. Aguirre [et al.] // J. Infect. Dis. – 2007. – Vol. 195, №6. – Р.870-878.
Decreased IFN- gamma and increased IL-4 production by human CD8(+) T cells in response to Mycobacterium tuberculosis in tuberculosis patients [Text] / S.M. Smith, M.R. Klein, A.S. Malin [et al.]// Tuberculosis. – 2002. – Vol. 82, №1. – Р.7-13.
Cytokine Profiles for Peripheral Blood Lymphocytes from Patients with Active Pulmonary Tuberculosis and Healthy Household Contacts in Response to the 30- Kilodalton Antigen of Mycobacterium tuberculosis
[Text] /Martha Torres, Teresa Herrera, Hector Villareal [et al.] // Infect. Immun. – 1998. – Vol. 66, №1. – 176– 180.
Cytokine profiles for peripheral blood lymphocytes from patients with active pulmonary tuberculosis and healthy household contacts in response to the 30- kilodalton antigen of Mycobacterium tuberculosis
[Text] / M. Torres, T. Herrera, H. Villareal [et al.]// Infect. Immun. – 1998. – Vol.66, №1. – Р. 176-80.
Lapach S.N. Statistical methods in biomedical studies using Excel [Text] / Lapach S.N., Chubenko A.V., Babich P.N. – Kyiv: Morion, 2000. – 320 p.
Downloads
How to Cite
Issue
Section
License
Copyright (c) 2020 Annals of Mechnikov's Institute
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 Unported License.
