The modern view of the etiology and treatment of pelvic pain in young women with genitals inflammation

Authors

  • A Chernyakova Kharkiv National Medical University,
  • O Kosilova Kharkiv National Medical University,
  • L Dobrovol'skaya Children's Clinic № 1, r .. Kharkov,

Keywords:

inflammatory diseases, antimicrobial treatment, harmons, women reproductive system, dismenorrhea.

Abstract

Sensitive issue of modern gynecology can be considered widespread and substantial "rejuvenation" of inflammatory diseases of the pelvic organs in women of reproductive age.Ascending path of infection prevails in the pathogenesis of inflammatory diseases of the internal genital organs. Invasion of microbes in the internal genital organs may occur during the various manipulations, different pelvic operations and  in the postpartum period. The degree of colonization of microorganisms of the vagina and cervix plays an important   role  in the development of the infectious process. In obstetrics and gynecology inflammatory diseases can be caused by pathogenic and non- pathogenic (opportunistic) microorganisms. Among the pathogens causing the defeat of the female genital organs, most often found N. gonorrhea, C. trachomatis, T. vaginalis. Opportunistic pathogens, part of the normal flora of the genital tract, in certain circumstances, can become agents of post-partum, post-abortion, post-operative complications and inflammatory diseases of the female genital organs. Among the opportunistic pathogens that are part of the normal microflora of the female genital organs, found hemolytic and non-hemolytic streptococci (the most important are streptococci groups A, B, D), coagulase-negative staphylococci and micrococci (allocated 60% and 35% of healthy women, respectively). They can cause secondary infectious processes of the urinary system, inflammatory diseases of the genital organs of pregnant women and mothers with immunosuppression. These microorganisms are often the agents of inflammatory diseases in the newborn, especially with low weight and malnutrition children. Gram-negative opportunistic bacteria that are isolated from the genital tract, can also be agents of inflammatory processes of various localization. Escherichia coli is the most frequently obtain and cause urinary tract infection in pregnant and postpartum women. It is also causative agent of postpartum sepsis and postoperative peritonitis. Among other gram-negative bacteria should be noted genus Klebsiella. Therefore, therapy of inflammatory diseases of the pelvic organs high demands due to the risk that represents this state to the reproductive function of patients. The mixed nature of the infection, the increasing rates of resistance of pathogens to antibiotics creates difficulties in selecting antimicrobial therapy, which remains the empirical  till now. The inclusion of specific bacteriophages and plant antiseptics in therapeutic regimens for local treatment of inflammatory diseases of the vagina associated with an excessive colonization of the vaginal mucosa by aerobic opportunistic bacteria justified and can serve as an alternative to the traditional antibiotic therapy.  All this determines the necessity for further studying   the etiology and pathogenesis of infectious and inflammatory complications, the development of new highly effective methods of prevention and treatment.

References

Tikhomirov A.L. The modern principles of prevention and treatment of inflammatory diseases of the female genital organs in the operational and non-operational gynecology [Text] / A.L. Tikhomirov, S.I. Sarsaniya // Guidelines. - 2005.

Cooper M.A. Fix the antibiotics pipeline [Text] / M.A. Cooper, D. Shlaes // Nature – 2011. – Vol.472(7341). – Р. 32.

Benyuk V.A. Dismenorea [Text] / V.A. Benyuk, I.B. Ventskovskaya // Medical aspects of women's health. - 2008. - №2 (11). – Р. 45 - 48.

Tuchkіna І.А. Some pathogenetic features of the course of puberty in adolescent girls with genitals inflammation on extragenital pathology background [Text] / І.А. Tuchkіna, G.M. Tisyachka // Belgorod State University. - 2014. - № 4 (175). - P. 79-82.

Rational pharmacotherapy in obstetrics and gynecology // guide for practitioners, edited by V. Kulakov, V.N. Serov - Moscow, "Litterra", 2005. - Р.724-727.

Handbook of Obstetrics, Gynecology and Perinatology [Text] / edited by G.M. Savelevoj. - M., "MIA", 2006 - Р.487-501.

Kutateladze M. Bacteriophages as potential new therapeutics to replace or supplement antibiotics [Text] / M. Kutateladze, R. Adamia // Trends in Biotechnology. – 2010. – Vol. 28(12). – Р. 591–595.

Bush K. Tackling antibiotic resistance [Text] / K. Bush, P. Courvalin, G. Dantas [et al] // Nature Reviews Microbiology. – 2011. – Vol. 9(12). – Р. 894–896.

Roberts R.R. Hospital and societal costs of antimicrobial-resistant infections in a chicago teaching hospital: implications for antibiotic stewardship [Text] / R.R. Roberts, B. Hota, L. Ahmad [et al] // Clinical Infectious Diseases. – 2009. – Vol. 49(8). – Р. 1175–1184.

Wattal C. Current status of newer antiinfectives [Text] / C. Wattal, J.K. Oberoi, R. Raveendran, K.J.Prasad // Recent Patents on Anti-Infective Drug Discovery. – 2008. – Vol.3(3). – Р. 206–224.

Fernebro J. Fighting bacterial infections—future treatment options [Text] / J. Fernebro // Drug Resistance Updates. – 2011. – Vol.14(2). – Р.125–139.

Ness R.B. Effectiveness of treatment strategies of some women with pelvic inflammatory disease: a randomized trial [Text] / R.B. Ness, G. Trautmann, H.E. Richter, H. Randall [et al.] // Obstet Gynecol. – 2005. – Vol. 106(3). – Р. 573–80.

Maura D. Bacteriophages as twenty-first century antibacterial tools for food and medicine [Text] / D. Maura, L. Debarbieux // Applied Microbiology and Biotechnology. – 2011. – Vol. 90(3). – Р. 851–859.

Kumarasamy K.K. Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study [Text] / K.K. Kumarasamy, M.A. Toleman, T.R. Walsh [et al] // The Lancet Infectious Diseases. – 2010. – Vol.10(9). – Р. 597–602.

Nikonov A.P. Diagnosis and antimicrobial chemotherapy of infections of the upper genital tract [Text] / A.P. Nikonov // Gynecology, ekstra edition. - 2005 – Р. 5-7.

Banikarim C. Pelvic inflammatory disease in adolescents [Text] / C. Banikarim, M.R.Chacko // Semin Pediatr Infect Dis. – 2005. – Vol. 16(3). – Р. 175-80.

Rice L.B. Federal funding for the study of antimicrobial resistance in nosocomial pathogens: no ESKAPE [Text] / L.B. Rice // Journal of Infectious Diseases. – 2008. – Vol.197(8). – Р.1079–1081.

Burrington-Brown J. AHIMA e-HIM Personal Health Record Work Group. Defining the personal health record. AHIM releases definition, attributes of consumer health record [Text] / J. Burrington-Brown, L.Fox [et al.] // J AHIMA. – 2005. – Vol. 76(6). – Р. 24-5.

Munyaradzi M. Critical reflections on the principle of beneficence in biomedicine [Text] / M. Munyaradzi // The Pan African Medical Journal. – 2012. – Vol.11, article 29 [PMC free article]

N.V. Lazareva "The role of the implementation of prevention in the areas of strengthening the reproductive health of the female population"/ Medical almanac / Obstetrics and Gynecology / - 2008 - № 4 (5) – pp. 124-125 / [Electron resource] / N.V.Lazareva// access mode http://www.medalmanac.ru/archive/year2008/number_four/obstetrics_gyn/gynaecology/?doc=468

Ness R.B., Effectiveness of treatment strategies of some women with pelvic inflammatory disease: a randomized trial [Text] / R.B. Ness, G. Trautmann, H.E. Richter, H. Randall [et al.] // Obstet Gynecol. – 2005. – Vol. 106(3). – Р. 573-80.

Eliseev E.V. The empirical antibiotic therapy of inflammatory diseases of the pelvic organs on the stationary phase [Text] / E.V. Eliseev [et al.] // Gynecology: Zh. for the Practical. physicians. - 2013. - Vol. 15. - N 1. – P.12-17.

Tkachenko L. Meaning of bacterial vaginosis treatment for the prevention of obstetric complications [Text] / L. Tkachenko, T. Składanowski // Gynecology: Zh. for the Practical. physicians. - 2013. - Vol. 15. – N 1. – P.18-25.

Dovlethanova E.R. Vaginal dysbiosis and its consequences: a rational approach to treatment [Text] / E.R Dovlethanova // Gynecology: Zh. for the Practical. physicians. - 2013. - Vol. 15. - N 1. – P. 63-65.

Tuchkina I.A. Clinico-pathogenetic features of inflammatory diseases of the genitals at puberty [Text] / I.A. Tuchkina, G.M. Tysyachka // Reproductive Health. Eastern Europe - 2014. - № 3 (33). - P. 64-69.

Benyuk V.A. Timely approach to complex adjustments dysmenorrhea [Text] / V.A. Benyuk, T.R. Nikonyuk, L.D. Lastavetska // Female Health - 2008. - №1 (33). – Р. 76 - 82.

Rapkin A.J. Relationships amongself-rated tanner staging hormones and psychosocial factors in healthy female adolescents [Text] / A.J. Rapkin, J.C. Tsao [et al] // J Pediatr Adolesc Gynecol. – 2006. – Vol.19 (3). – Р. 181 – 187.

Yudina M.A. Optimization of treatment of bacterial vaginosis [Text] / M.A. Yudina, G.O. Grechkanev, R. Chandra D`Mello // Medical almanac – 2012. – №5 (24) – Р.93-95.

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How to Cite

Chernyakova, A., Kosilova, O., & Dobrovol’skaya, L. (2020). The modern view of the etiology and treatment of pelvic pain in young women with genitals inflammation. Annals of Mechnikov’s Institute, (4), 27–31. Retrieved from https://journals.uran.ua/ami/article/view/208182

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Reviews