Ivermectin - molecular mechanisms of antivirus and antiparasitic effects

Abstract

Specific highly affinity recognition of imports is crucial for the viral proteins nuclear localization. One of the drugs that affects the viral nuclear localization signal is ivermectin. It is shown that the addition of 5 mcM ivermectin to Vero-hSLAM cells 2 hours after the SARS-COV-2 infection led to a decrease in the viral RNA load by 99.98% after 48 hours. Ivermectin for treatment SARS-COV-2 people have already approved in a number of states and countries, including Peru and the Northeastern region of Beni in Bolivia. It is important to note that about 70 tests around the world are currently checking the clinical efficacy of ivermectin for the treatment or prevention of SARS-COV-2; They include variations in dosing modes, combined therapy and prophylactic protocols. Scientists suggested that this drug can reduce viral load in infected patients with potential influence on the progression and dissemination of the disease. Possible directions for the further study of the recruitment of Ivermectin for the treatment of SARS-COV-2 may be in the development of an inhalation preparation for the effective delivery of high local concentration into the lungs with minimal systemic exposure and estimating the synergistic effects of ivermectin with other connections that also inhibit SARS-COV-2 replication.

DOI: 10.5281/zenodo.4657699