Formulation and evaluation of the nanosilver gel using bioreductor ethanol extract of Katuk leaf (Sauropus androgynus (l) Merr) as antibacterial

Abstract

Introduction: The current type of nanoparticle that attracts a lot of attention in the pharmaceutical field is Nanosilver. Nanosilver can be acted as an antimicrobial. The aim of this study is to obtain the Nanosilver gel preparation from katuk leaf extract, which is effective as an antibacterial agent against acne. Materials and Methods: Katuk leaf extract remains as a reducing agent in the synthesis of Nanosilver using a green synthesis method. Nanosilver characterization was performed using PSA, FTIR and TEM. Results and Discussions: Particle size of Nanosilver (Katuk leaf extract concentration 0.16% with a silver nitrate volume of 10 mM is 1: 9) of 164.40 nm, Nanosilver (Katuk leaf extract Concentration 0.32% with silver nitrate volume 10 mM is 1: 9) of 176.47 nm and Nanosilver (0.48% katuk leaf extract concentration with a volume of 10 mm silver nitrate of 1: 9) of 194.95 nm. Antibacterial activity using the Well method was shown that the nanosilver gel from Katuk leaf extract had an inhibitory effect on P. acnes bacteria with an inhibition zone of 26 mm  classified as very strong, and 12 mm was strongly categorized against S. aureus bacteria, namely in Formula 1. Conclusion: A variation in the concentration of katuk leaf extract influences the size of the particles formed. The Nanosilver of katuk leaf extract has an antibacterial cause for acne with a very strong category.

DOI: 10.5281/zenodo.4657734