Development of adhesive for full removable dentures fixing


  • Yuliia Maslii National University of Pharmacy, Ukraine
  • Alexandra Rebrova National University of Pharmacy, Ukraine
  • Olena Ruban National University of Pharmacy, Ukraine


Introduction. Nowadays in Ukraine, a large number of people suffer from tooth loss, which is most often due to age, injuries, diseases or insufficient care of the oral cavity. The reliable and most common way to restore dentition defects today is removable prosthetics. However, adaptation to prostheses is often accompanied by injury to the mucous membrane: inflammation, bleeding, ulceration, etc., which interferes with the normal fixation of prostheses in the oral cavity, leads to pain and reduces the quality of patient’s life. That is why when using removable prostheses, special adhesives are necessary, which in most cases solve only the problem of fixing a removable denture, without providing any therapeutic effect. The aim of our work was to develop a new adhesive for fixing removable dentures with salvia essential oil, which has been widely used in dental practice and proved antimicrobial, antiseptic, anti-inflammatory, hemostatic, analgesic and regenerative effects. Material & methods. The following objects were selected: API – salvia essential oil; excipients – a copolymer of methyl vinyl ether and maleic anhydride (PMV/MA) under the trade name OraRez® MS (adhesive polymer), carboxymethylcellulose (adhesive polymer and consistency regulator), vaseline and vaseline oil (base-vehicle, thickener). The following parameters were tested: organoleptic, homogeneity, colloidal stability, structural-mechanical (rheological) properties, adhesion ability. The studies were performed in comparison with the reference drug "Protefix" (Kweisser Pharma GmbH and Co. KG, Germany). Results & discussion. According to the results of organoleptic and physicochemical studies, it was found that the increase in the concentration of vaseline in the adhesive caused an increase in the viscosity of the system, which, in turn, leaded to clumping and inhomogeneous mass. At the same time, increasing the quantity of vaseline oil leaded to a decrease in the viscosity of the mass and to its stratification. On this basis, the rational concentration of vaseline oil and vaseline was selected 25% and 19%, respectively, which allowed obtaining a homogeneous and stable system. According to the results of structural-mechanical studies, it was found that increasing the concentration of carboxymethylcellulose leaded to an increase in the viscosity of the adhesive. Based on the obtained rheograms and adhesion test results, the sample containing carboxymethylcellulose and OraRez® MS with concentrations of 30% and 25%, respectively, was selected, which was as close as possible to the reference preparation in terms of its rheological behavior, viscosity characteristics and adhesion strength. Conclusion. As stated in the results of a number of experimental studies, a rational composition of the new adhesive with salvia essential oil was developed, which would allow expanding the range of domestic drugs for prostheses fixing on the pharmaceutical market of Ukraine.

DOI: 10.5281/zenodo.5761223

Author Biography

Yuliia Maslii, National University of Pharmacy

доцент кафедри заводської технології ліків



How to Cite

Maslii, Y. ., Rebrova, A., & Ruban, O. (2021). Development of adhesive for full removable dentures fixing. Annals of Mechnikov’s Institute, (4), 39–44. Retrieved from



Research Articles