Study of antimicrobial properties of pharmaceutical medication in the ointment form for treatment of mixed skin infections
DOI:
https://doi.org/10.5281/zenodo.15662782Keywords:
herpes, acyclovir, miramistin, patchouli essential oil, ointment, technology, pharmaceutical development, mixed infectionsAbstract
According to the WHO, 60 to 95% of the world's population with skin lesions are infected with an association of representatives from the herpesvirus family and bacterial flora. In recent years, infections caused by only one type of herpes or microorganism are becoming less common. The most commonly observed infections are mixed infections (63.7%) and those with bacterial flora, which are accompanied by various clinical manifestations and require special approaches to treatment. The development of mix-infections and resistance to single-agent drugs necessitate the development and implementation of combination drugs for effective treatment with a complex effect on the virus and bacteria and the associated infection. Purpose of the work: conducting microbiological studies of a pharmaceutical development in the form of an ointment for the treatment of herpesvirus mixed skin infections. Materials and methods: The object of the study is patchouli essential oil, a combined ointment with acyclovir, miramistin and patchouli essential oil, a comparison drug is a combined cream for the treatment of herpes "Herpesil" manufactured by New Medical Promotion LLC (Ukraine). Microbiological studies using the agar diffusion method were carried out in the laboratory of biochemistry and biotechnology of the State Institution "IMI named I. I. Mechnikov of the National Academy of Medical Sciences of Ukraine". Results: Microbiological studies have established that the combined proposed agent in the form of an ointment additionally exhibits antibacterial and antifungal properties to various test cultures and clinical isolates of microorganisms. Conclusions. The development of mixed infections necessitates the creation and introduction of combined drugs. For the treatment of herpesvirus mixed skin infections, a new drug in the form of an ointment with acyclovir, miramistin and patchouli essential oil has been proposed. The antiseptic properties of miramistin in combination with patchouli essential oil, the biologically active substances of which have antimicrobial activity, contribute to the expansion of the spectrum of action of acyclovir. The antiviral activity of the proposed agent has a high therapeutic effect, the index of therapeutic action is 94.2%. The wide spectrum of antimicrobial and antiviral action of the new proposed pharmaceutical development will have a comprehensive effect on associated herpesvirus mixed skin infections.
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