Synthesis of cocarboxylase: process intensification via microwave irradiation

Authors

  • Наталия Александровна Пинчукова “Institute for Single Crystals” of NAS of Ukraine Lenin Av. 60, Kharkiv, Ukraine, 61001, Ukraine
  • Александр Юрьевич Волошко “Institute for Single Crystals” of NAS of Ukraine Lenin Av. 60, Kharkiv, Ukraine, 61001, Ukraine
  • Николай Юрьевич Горобец “Institute for Single Crystals” of NAS of Ukraine Lenin Av. 60, Kharkiv, Ukraine, 61001, Ukraine
  • Константин Николаевич Беликов “Institute for Single Crystals” of NAS of Ukraine Lenin Av. 60, Kharkiv, Ukraine, 61001, Ukraine
  • Людмила Васильевна Гудзенко “Institute for Single Crystals” of NAS of Ukraine Lenin Av. 60, Kharkiv, Ukraine, 61001, Ukraine
  • Валентин Анатольевич Чебанов “Institute for Single Crystals” of NAS of Ukraine Lenin Av. 60, Kharkiv, Ukraine, 61001, Ukraine

DOI:

https://doi.org/10.15587/1729-4061.2013.19203

Keywords:

microwave radiation, thermal heating, phosphorylation, dehydration, polyphosphoric acid, energy saving, scaling

Abstract

Energy saving is the key point in the development of new chemical technologies and industrial scaling of the processes of obtaining chemical reagents, functional materials, pharmaceutical substances, etc. The use of the non-classical process activation methods, including microwave radiation, known as effective heating source, allowing significant process acceleration, is a promising direction in the field of new energy-saving technologies.

The paper gives the results of modeling of the process of synthesis of cocarboxylase - known pharmaceutical substance - in a microwave field. The synthesis includes two stages – preparation of polyphosphoric acid (phosphorylating agent) and phosphorylation of thiamine chloride. The effect of microwave radiation on duration and energy parameters of these processes of various scales (from several grams to several kilograms) was studied. The efficiency of the microwave radiation use at both stages from the point of view of influence on the duration of processes and energy consumption was shown. The effective technique of the preparation of polyphosphoric acid by the method of phosphoric acid dehydration in the microwave field was developed. Optimal parameters of microwave thiamine chloride phosphorylation were found. The comparative assessments of time and energy expenditure in these processes, including taking into account their scaling to the industrial volumes were given for the justification of the economic feasibility of replacing the thermal heating by microwave radiation.

Author Biographies

Наталия Александровна Пинчукова, “Institute for Single Crystals” of NAS of Ukraine Lenin Av. 60, Kharkiv, Ukraine, 61001

Junior researcher in State Scientific Institution

Александр Юрьевич Волошко, “Institute for Single Crystals” of NAS of Ukraine Lenin Av. 60, Kharkiv, Ukraine, 61001

Senior researcher in State Scientific Institution

Николай Юрьевич Горобец, “Institute for Single Crystals” of NAS of Ukraine Lenin Av. 60, Kharkiv, Ukraine, 61001

Senior researcher in State Scientific Institution

Константин Николаевич Беликов, “Institute for Single Crystals” of NAS of Ukraine Lenin Av. 60, Kharkiv, Ukraine, 61001

Head of Department in State Scientific Institution

Людмила Васильевна Гудзенко, “Institute for Single Crystals” of NAS of Ukraine Lenin Av. 60, Kharkiv, Ukraine, 61001

Junior researcher in State Scientific Institution

Валентин Анатольевич Чебанов, “Institute for Single Crystals” of NAS of Ukraine Lenin Av. 60, Kharkiv, Ukraine, 61001

Deputy Director-General of State Scientific Institution

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Published

2013-12-17

How to Cite

Пинчукова, Н. А., Волошко, А. Ю., Горобец, Н. Ю., Беликов, К. Н., Гудзенко, Л. В., & Чебанов, В. А. (2013). Synthesis of cocarboxylase: process intensification via microwave irradiation. Eastern-European Journal of Enterprise Technologies, 6(6(66), 20–26. https://doi.org/10.15587/1729-4061.2013.19203

Issue

Vol. 6 No. 6(66) (2013): Technology of organic and inorganic substanse

Section

Technology organic and inorganic substances

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Copyright (c) 2014 Наталия Александровна Пинчукова, Александр Юрьевич Волошко, Николай Юрьевич Горобец, Константин Николаевич Беликов, Людмила Васильевна Гудзенко, Валентин Анатольевич Чебанов

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