Design of geriatric drug potentially increasing adiponectin expression

Authors

  • Діана Іванівна Данилко Kyiv National University of Technology and Design Nemirovich-Danchenko str., 2, Kyiv, Ukraine, 01011, Ukraine https://orcid.org/0000-0003-2684-5389
  • Володимир Іванович Бессарабов Kyiv National University of Technology and Design Nemyrovych-Danchenko st., 2, Kiev, Ukraine, 01011, Ukraine https://orcid.org/0000-0003-0637-1729
  • Тетяна Андріївна Пальчевська Kyiv National University of Technology and Design Nemirovich-Danchenko str., 2, Kyiv, Ukraine, 01011, Ukraine https://orcid.org/0000-0001-9532-7812

DOI:

https://doi.org/10.15587/2519-4852.2016.81471

Keywords:

adiponectin, metabolic syndrome, insulin resistance, endotoxicity, exotoxicity, in silico, virtual screening

Abstract

Aim. The aim is to create in silico composition of the complex geriatric drug that is able to increase adiponectin expression in patients with symptoms of the metabolic syndrome.

Methods. The study was carried out by using in silico virtual screening with Prediction of Activity Spectra for Substances (PASS).

Results. The first phase of the study included 65 substances that were analyzed for the probability of ADIPOQ gene activation separately according to the protein and mRNA. The research allowed selecting the perspective APIs that are probable to increase expression of adiponectin with a maximum activity (Ra), namely active components of Valeriana officinalis L. extract – isovaleric acid, valeric acid, and γ-aminobutyric acid. Endo- and exotoxicity assessment revealed that the designed drug API have low toxicity.

Conclusion. Proposed composition of the geriatric drug increasing the expression of adiponectin (based on ADIPOQ gene activation), is perspective for further pharmacological, biopharmaceutical properties research and development of dosage forms

Author Biographies

Діана Іванівна Данилко, Kyiv National University of Technology and Design Nemirovich-Danchenko str., 2, Kyiv, Ukraine, 01011

Department of Industrial Pharmacy

Володимир Іванович Бессарабов, Kyiv National University of Technology and Design Nemyrovych-Danchenko st., 2, Kiev, Ukraine, 01011

PhD, associate professor

Department of Industrial Pharmacy

Тетяна Андріївна Пальчевська, Kyiv National University of Technology and Design Nemirovich-Danchenko str., 2, Kyiv, Ukraine, 01011

PhD, associate professor

Department of Industrial Pharmacy

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Published

2016-10-30

How to Cite

Данилко, Д. І., Бессарабов, В. І., & Пальчевська, Т. А. (2016). Design of geriatric drug potentially increasing adiponectin expression. ScienceRise: Pharmaceutical Science, (3 (3), 55–59. https://doi.org/10.15587/2519-4852.2016.81471

Issue

No. 3 (3) (2016)

Section

Pharmaceutical Science

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Copyright (c) 2016 Діана Іванівна Данилко, Володимир Іванович Бессарабов, Тетяна Андріївна Пальчевська

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