Design of geriatric drug potentially increasing adiponectin expression
DOI:
https://doi.org/10.15587/2519-4852.2016.81471Keywords:
adiponectin, metabolic syndrome, insulin resistance, endotoxicity, exotoxicity, in silico, virtual screeningAbstract
Aim. The aim is to create in silico composition of the complex geriatric drug that is able to increase adiponectin expression in patients with symptoms of the metabolic syndrome.
Methods. The study was carried out by using in silico virtual screening with Prediction of Activity Spectra for Substances (PASS).
Results. The first phase of the study included 65 substances that were analyzed for the probability of ADIPOQ gene activation separately according to the protein and mRNA. The research allowed selecting the perspective APIs that are probable to increase expression of adiponectin with a maximum activity (Ra), namely active components of Valeriana officinalis L. extract – isovaleric acid, valeric acid, and γ-aminobutyric acid. Endo- and exotoxicity assessment revealed that the designed drug API have low toxicity.
Conclusion. Proposed composition of the geriatric drug increasing the expression of adiponectin (based on ADIPOQ gene activation), is perspective for further pharmacological, biopharmaceutical properties research and development of dosage forms
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