Influence of physicochemical properties and structure of mixed solvents propylene glycol – macrogol 400 on their in vitro release

Authors

DOI:

https://doi.org/10.15587/2519-4852.2023.274468

Keywords:

propylene glycol, macrogol 400, solvent, density, viscosity, activation parameters of viscous flow, in vitro release

Abstract

Aim. To study the density and dynamic viscosity of the mixed solvents propylene glycol (PG) – macrogol 400 (M400), to calculate their excess values and excess activation parameters of viscous flow, to evaluate the features of the structure of the mixed solvents and its influence on the in vitro release of PG and M400.

Materials and methods. The mixed solvents PG - M400 were studied over the entire concentration range at temperatures from 293.15 to 313.15 K. The density and dynamic viscosity were determined, and the excess density, excess dynamic viscosity, activation parameters of viscous flow, and excess activation parameters of viscous flow were calculated. The in vitro release of PG and M400 from the mixed solvents was studied using vertical diffusion cells. The content of PG and M400 in the receptor medium was determined by gas chromatography using validated analytical procedures. The release rate, cumulative content, percentage of released PG or M400, coefficients of correlation and coefficients of determination were calculated.

Results. The isotherms of excess density and excess dynamic viscosity of the mixed solvents PG-M400 pass through a maximum. The enthalpy makes the main contribution to the free activation energy of the viscous flow. The excess free energy is positive and has small values; the values of the excess entropy and excess enthalpy are negative, and the isotherms have the minimum at PG concentrations of 70‑75mol %. The release parameters of M400 are greater in binary mixtures where the M400 structure predominates. At PG content of ~75 mol %, the release parameters for PG and M400 are identical. With the increase in PG content above 75 mol %, when the PG structure predominates in the system, the release parameters of PG increase dramatically, and the release parameters of M400 decrease sharply.

Conclusions. The structure of the binary system PG – M400 depends on its composition. Based on the isotherms of excess activation of viscous flow, it is possible to differentiate the areas where the structure of PG or the structure of M400 dominates, or the mixed structure of the binary solvent prevails. The in vitro release parameters for PG and M400 depend on the structure of the mixed solvents. The greatest difference in the release parameters of PG and M400 was observed in the area where the structure of PG dominates

Author Biographies

Elena Bezuglaya, State Scientific Institution «Institute for Single Crystals» of National Academy of Sciences of Ukraine

PhD, Senior Researcher, Head of Laboratory

Laboratory of Technology and Analysis of Medicinal Products

Alla Krasnopyorova, V. N. Karazin Kharkiv National University

PhD, Senior Researcher, Head of Department

Department of Radiochemistry and Radioecology

Anna Liapunova, State Scientific Institution «Institute for Single Crystals» of National Academy of Sciences of Ukraine

PhD, Researcher

Laboratory of Technology and Analysis of Medicinal Products

Igor Zinchenko, State Scientific Institution «Institute for Single Crystals» of National Academy of Sciences of Ukraine

PhD, Junior Researcher

Laboratory of Technology and Analysis of Medicinal Products

Nikolay Lyapunov, State Scientific Institution «Institute for Single Crystals» of National Academy of Sciences of Ukraine

Doctor of Pharmaceutical Sciences, Professor, Leading Researcher

Laboratory of Technology and Analysis of Medicinal Products

Oksana Sytnik, Branch of Ukrainian Scientific Research Institute of Natural Gases of Joint Stock Company "Ukrgazvydobuvannya"

PhD, Head of Laboratory

Laboratory of Ecological Research

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Published

2023-02-28

How to Cite

Bezuglaya, E., Krasnopyorova, A., Liapunova, A., Zinchenko, I., Lyapunov, N., & Sytnik, O. (2023). Influence of physicochemical properties and structure of mixed solvents propylene glycol – macrogol 400 on their in vitro release. ScienceRise: Pharmaceutical Science, (1(41), 4–13. https://doi.org/10.15587/2519-4852.2023.274468

Issue

No. 1(41) (2023)

Section

Pharmaceutical Science

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Copyright (c) 2023 Elena Bezuglaya, Alla Krasnopyorova, Anna Liapunova, Igor Zinchenko, Nikolay Lyapunov, Oksana Sytnik

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