Аналіз сучасного стану розроблення мікроголкових систем для трансдермальної доставки ліків (a scoping review)

Автор(и)

  • Любов Анатоліївна Боднар Національний фармацевтичний університет, Україна https://orcid.org/0000-0002-3268-0683
  • Тетяна Миколаївна Ковальова Національний фармацевтичний університет, Україна https://orcid.org/0000-0002-5984-6196
  • Наталя Вячеславівна Сидора Приватний вищий навчальний заклад «Київський медичний університет», Україна https://orcid.org/0000-0002-3333-2250
  • Олександр Олександрович Шмалько Чорноморський національний університет імені Петра Могили, Україна https://orcid.org/0000-0002-5777-0896
  • Ігор Іванович Бердей Тернопільський національний медичний університет імені І. Я. Горбачевського, Україна https://orcid.org/0000-0002-8344-1033
  • Лілія Іванівна Вишневська Національний фармацевтичний університет, Україна https://orcid.org/0000-0002-6887-3591

DOI:

https://doi.org/10.15587/2519-4852.2026.352761

Ключові слова:

мікроголкова система, трансдермальна доставка, покращення проникнення діючих речовин, бібліосемантичний аналіз

Анотація

Мета дослідження – вивчення сучасного стану розроблення мікроголкових систем для трансдермальної доставки ліків.

Матеріали і методи. Аналіз, систематизація та узагальнення даних наукових літературних джерел щодо розроблення мікроголкових систем, дослідження їх ефективності та перспектив використання у фармації. Використовували модифіковану методику Arskey та O’Malley, доопрацьовану науковою групою під керівництвом H.M. Daudt. Загалом проаналізовано 480 публікацій за останні десять років.

Результати. Результати аналізу свідчать, що основна частина експериментальних досліджень зосереджена на розробці мікроголкових систем для трансдермальної доставки вакцин, інсуліну та анальгетиків. Натомість дослідження, присвячені створенню препаратів з іншою направленістю дії або препаратів для поступового вивільнення активних речовин за допомогою мікроголок, займають менший сегмент від загальної кількості.

Висновки. Встановлено, що більшість вчених обирають напрям розроблення препаратів з мікроголками для системного застосування. Основними напрямами публікацій є огляд літературних джерел, розроблення нових мікроголкових систем тощо. Отримані результати вказують на потенціал і актуальність проведення досліджень з розроблення мікроголкових систем

Біографії авторів

Любов Анатоліївна Боднар, Національний фармацевтичний університет

Асистент

Кафедра аптечної технології ліків

Тетяна Миколаївна Ковальова, Національний фармацевтичний університет

Кандидат фармацевтичних наук, доцент

Кафедра аптечної технології ліків

Наталя Вячеславівна Сидора, Приватний вищий навчальний заклад «Київський медичний університет»

Доктор фармацевтичних наук, професор

Кафедра фармацевтичної і біологічної хімії, фармакогнозії

Олександр Олександрович Шмалько, Чорноморський національний університет імені Петра Могили

Доктор фармацевтичних наук, доцент

Кафедра фармації, фармакології, медичної, біоорганічної та біологічної хімії

Медичний інститут

Ігор Іванович Бердей, Тернопільський національний медичний університет імені І. Я. Горбачевського

Кандидат фармацевтичних наук, доцент

Кафедра управління та економіки фармації з технологією ліків

Лілія Іванівна Вишневська, Національний фармацевтичний університет

Доктор фармацевтичних наук, професорка, завідувачка кафедри

Кафедра аптечної технології ліків

Посилання

  1. Daudt, H. M., van Mossel, C., Scott, S. J. (2013). Enhancing the scoping study methodology: a large, inter-professional team’s experience with Arksey and O’Malley’s framework. BMC Medical Research Methodology, 13 (1). https://doi.org/10.1186/1471-2288-13-48
  2. Ledger, P. W., Nichols, K. C. (1989). Transdermal drug delivery devices. Clinics in Dermatology, 7 (3), 25–31. https://doi.org/10.1016/0738-081x(89)90004-7
  3. Henry, S., McAllister, D. V., Allen, M. G., Prausnitz, M. R. (1998). Microfabricated Microneedles: A Novel Approach to Transdermal Drug Delivery. Journal of Pharmaceutical Sciences, 87 (8), 922–925. https://doi.org/10.1021/js980042+
  4. Prausnitz, M. R., Langer, R. (2008). Transdermal drug delivery. Nature Biotechnology, 26 (11), 1261–1268. https://doi.org/10.1038/nbt.1504
  5. Gill, H. S., Prausnitz, M. R. (2007). Coated microneedles for transdermal delivery. Journal of Controlled Release, 117 (2), 227–237. https://doi.org/10.1016/j.jconrel.2006.10.017
  6. Davis, S. P., Martanto, W., Allen, M. G., Prausnitz, M. R. (2005). Hollow Metal Microneedles for Insulin Delivery to Diabetic Rats. IEEE Transactions on Biomedical Engineering, 52 (5), 909–915. https://doi.org/10.1109/tbme.2005.845240
  7. Ameri, M., Kadkhodayan, M., Nguyen, J., Bravo, J., Su, R., Chan, K. et al. (2014). Human Growth Hormone Delivery with a Microneedle Transdermal System: Preclinical Formulation, Stability, Delivery and PK of Therapeutically Relevant Doses. Pharmaceutics, 6 (2), 220–234. https://doi.org/10.3390/pharmaceutics6020220
  8. Kim, Y.-C., Park, J.-H., Prausnitz, M. R. (2012). Microneedles for drug and vaccine delivery. Advanced Drug Delivery Reviews, 64 (14), 1547–1568. https://doi.org/10.1016/j.addr.2012.04.005
  9. Donnelly, R. F., McCrudden, M. T. C., Zaid Alkilani, A., Larrañeta, E., McAlister, E., Courtenay, A. J. et al. (2014). Hydrogel-Forming Microneedles Prepared from “Super Swelling” Polymers Combined with Lyophilised Wafers for Transdermal Drug Delivery. PLoS ONE, 9 (10), e111547. https://doi.org/10.1371/journal.pone.0111547
  10. Zhang, Y. S., Yue, K., Aleman, J., Mollazadeh-Moghaddam, K., Bakht, S. M., Yang, J. et al. (2016). 3D Bioprinting for Tissue and Organ Fabrication. Annals of Biomedical Engineering, 45 (1), 148–163. https://doi.org/10.1007/s10439-016-1612-8
  11. Kulkarni, D., Damiri, F., Rojekar, S., Zehravi, M., Ramproshad, S., Dhoke, D. et al. (2022). Recent Advancements in Microneedle Technology for Multifaceted Biomedical Applications. Pharmaceutics, 14 (5), 1097. https://doi.org/10.3390/pharmaceutics14051097
  12. Gowda, B. H. J., Ahmed, M. G., Sahebkar, A., Riadi, Y., Shukla, R., Kesharwani, P. (2022). Stimuli-Responsive Microneedles as a Transdermal Drug Delivery System: A Demand-Supply Strategy. Biomacromolecules, 23 (4), 1519–1544. https://doi.org/10.1021/acs.biomac.1c01691
  13. Zulcaif, Zafar, N., Mahmood, A., Sarfraz, R. M., Elaissari, A. (2022). Simvastatin Loaded Dissolvable Microneedle Patches with Improved Pharmacokinetic Performance. Micromachines, 13 (8), 1304. https://doi.org/10.3390/mi13081304
  14. Sekar, L., Seenivasan, R., Reddy, M. V., Varma, K. D., Ahmed, S. S., Pachiyappan, J. K., Ganesh, G. (2024). Advancements in microneedle technology: comprehensive insights into versatile drug delivery mechanisms. International Journal of Applied Pharmaceutics, 16 (2), 1–11. https://doi.org/10.22159/ijap.2024v16i2.49564
  15. Zhang, X., Wang, Y., Chi, J., Zhao, Y. (2020). Smart Microneedles for Therapy and Diagnosis. Research, 2020. https://doi.org/10.34133/2020/7462915
  16. Balde, A., Kim, S.-K., Nazeer, R. A. (2025). A review on microneedle patch as a delivery system for proteins/peptides and their applications in transdermal inflammation suppression. International Journal of Biological Macromolecules, 307, 141963. https://doi.org/10.1016/j.ijbiomac.2025.141963
  17. Khalid, R., Mahmood, S., Mohamed Sofian, Z., Hilles, A. R., Hashim, N. M., Ge, Y. (2023). Microneedles and Their Application in Transdermal Delivery of Antihypertensive Drugs – A Review. Pharmaceutics, 15 (8), 2029. https://doi.org/10.3390/pharmaceutics15082029
  18. Gowda, B. H. J., Ahmed, M. G., Thakur, R. R. S., Donnelly, R. F., Vora, L. K. (2024). Microneedles as an Emerging Platform for Transdermal Delivery of Phytochemicals. Molecular Pharmaceutics, 21 (12), 6007–6033. https://doi.org/10.1021/acs.molpharmaceut.4c00894
  19. Wu, C., Yu, Q., Huang, C., Li, F., Zhang, L., Zhu, D. (2024). Microneedles as transdermal drug delivery system for enhancing skin disease treatment. Acta Pharmaceutica Sinica B, 14 (12), 5161–5180. https://doi.org/10.1016/j.apsb.2024.08.013
  20. Shin, J. Y., Han, D., Yoon, K. Y., Jeong, D. H., Park, Y. I. (2024). Clinical Safety and Efficacy Evaluation of a Dissolving Microneedle Patch Having Dual Anti-Wrinkle Effects With Safe and Long-Term Activities. Annals of Dermatology, 36 (4), 215–224. https://doi.org/10.5021/ad.23.136
  21. Chen, J., Ren, H., Zhou, P., Zheng, S., Du, B., Liu, X., Xiao, F. (2022). Microneedle-mediated drug delivery for cutaneous diseases. Frontiers in Bioengineering and Biotechnology, 10. https://doi.org/10.3389/fbioe.2022.1032041
  22. Jaiswal, S., Jawade, S. (2024). Microneedling in Dermatology: A Comprehensive Review of Applications, Techniques, and Outcomes. Cureus, 16 (9). https://doi.org/10.7759/cureus.70033
  23. Mashi, A., Oraybi, R. A., Hakami, M. S., Altalhi, A. M., Alrezqi, W. A., Hakami, T. K. et al. (2025). Microneedling for Non-cosmetic Dermatologic Conditions: A Systematic Review of Efficacy and Safety. Cureus, 18 (7). https://doi.org/10.7759/cureus.90857
  24. Tehrani, L., Tashjian, M., Mayrovitz, H. N. (2025). Physiological Mechanisms and Therapeutic Applications of Microneedling: A Narrative Review. Cureus, 17 (3). https://doi.org/10.7759/cureus.80510
  25. Vyshnevska, L. I. (2023). Rozchynni mikroholky yak odna z innovatsiinykh tekhnolohii transdermalnykh system dostavky likarskykh preparativ. Suchasni dosiahnennia farmatsevtychnoi spravy. Kharkiv, 138–142. Available at: https://dspace.nuph.edu.ua/bitstream/123456789/30828/1/138-142.pdf
  26. Wadte, S. S., Hatwar, P. R., Bakal, R. L., Korde, D. V. (2025). Microneedle technology: An innovative approach for transdermal drug delivery and vaccine administration. International Journal of Pharmacy and Pharmaceutical Science, 7 (1), 194–202. https://doi.org/10.33545/26647222.2025.v7.i1c.168
  27. Zhu, D. D., Zhang, X. P., Zhang, B. L., Hao, Y. Y., Guo, X. D. (2020). Safety Assessment of Microneedle Technology for Transdermal Drug Delivery: A Review. Advanced Therapeutics, 3 (8). https://doi.org/10.1002/adtp.202000033
  28. Sivamani, R. K., Stoeber, B., Wu, G. C., Zhai, H., Liepmann, D., Maibach, H. (2005). Clinical microneedle injection of methyl nicotinate: stratum corneum penetration. Skin Research and Technology, 11 (2), 152–156. https://doi.org/10.1111/j.1600-0846.2005.00107.x
  29. Lee, I.-C., He, J.-S., Tsai, M.-T., Lin, K.-C. (2015). Fabrication of a novel partially dissolving polymer microneedle patch for transdermal drug delivery. Journal of Materials Chemistry B, 3 (2), 276–285. https://doi.org/10.1039/c4tb01555j
  30. Yamagishi, R., Miura, S., Yabu, K., Ando, M., Hachikubo, Y., Yokoyama, Y. et al. (2024). Fabrication Technology of Self-Dissolving Sodium Hyaluronate Gels Ultrafine Microneedles for Medical Applications with UV-Curing Gas-Permeable Mold. Gels, 10 (1), 65. https://doi.org/10.3390/gels10010065
  31. Zhang, L., Guo, R., Wang, S., Yang, X., Ling, G., Zhang, P. (2021). Fabrication, evaluation and applications of dissolving microneedles. International Journal of Pharmaceutics, 604, 120749. https://doi.org/10.1016/j.ijpharm.2021.120749
  32. Andranilla, Rr. K., Anjani, Q. K., Hartrianti, P., Donnelly, R. F., Ramadon, D. (2023). Fabrication of dissolving microneedles for transdermal delivery of protein and peptide drugs: polymer materials and solvent casting micromoulding method. Pharmaceutical Development and Technology, 28 (10), 1016–1031. https://doi.org/10.1080/10837450.2023.2285498
  33. Bai, C., Huo, C., Zhang, P. (2020). Dissolving Microneedles for Transdermal Drug Delivery System. Journal of Physics: Conference Series, 1626 (1), 012104. https://doi.org/10.1088/1742-6596/1626/1/012104
  34. Yu, X., Zhao, J., Fan, D. (2023). The Progress in the Application of Dissolving Microneedles in Biomedicine. Polymers, 15 (20), 4059. https://doi.org/10.3390/polym15204059
  35. Yadav, P. R., Hingonia, P., Das, D. B., Pattanayek, S. K. (2024). Modeling of Dissolving Microneedle-Based Transdermal Drug Delivery: Effects of Dynamics of Polymers in Solution. Molecular Pharmaceutics, 21 (10), 5104–5114. https://doi.org/10.1021/acs.molpharmaceut.4c00492
  36. Bandral, M. R., Padgavankar, P. H., Japatti, S. R., Gir, P. J., Siddegowda, C. Y., Gir, R. J. (2018). Clinical Evaluation of Microneedling Therapy in the Management of Facial Scar: A Prospective Randomized Study. Journal of Maxillofacial and Oral Surgery, 18 (4), 572–578. https://doi.org/10.1007/s12663-018-1155-7
  37. Hirobe, S., Azukizawa, H., Matsuo, K., Zhai, Y., Quan, Y.-S., Kamiyama, F. et al. (2013). Development and Clinical Study of a Self-Dissolving Microneedle Patch for Transcutaneous Immunization Device. Pharmaceutical Research, 30 (10), 2664–2674. https://doi.org/10.1007/s11095-013-1092-6
  38. Bahadur, S., Radhika, Sahu, K. K., Singh, A. K. (2025). Advances and Challenges of Microneedle Assisted Drug Delivery for Biomedicals Applications: A Review. Current Pharmaceutical Biotechnology, 26 (16), 2566–2577. https://doi.org/10.2174/0113892010310769240924053724
  39. Vergilio, M. M., Birchall, J. C., Lima, L. L., Rezende, R. A., Leonardi, G. R. (2024). Drug Delivery Systems based on Microneedles for Dermatological Diseases and Aesthetic Enhancement. Current Medicinal Chemistry, 31 (23), 3473–3487. https://doi.org/10.2174/0929867330666230525122913
  40. Nagod, S., Halse, D. S. V. (2020). MEMS Based Microneedles in the Field of Drug Delivery. International Journal of Innovative Technology and Exploring Engineering, 9 (4), 2863–2867. https://doi.org/10.35940/ijitee.d1761.029420
  41. Huang, Y., Yu, H., Wang, L., Shen, D., Ni, Z., Ren, S. et al. (2022). Research progress on cosmetic microneedle systems: Preparation, property and application. European Polymer Journal, 163, 110942. https://doi.org/10.1016/j.eurpolymj.2021.110942
  42. Huo, T., Zhou, L., Bian, X., Wen, Y. (2025). Advancing microneedle technology for multiple distinct target organs drug delivery through 3D printing: a comprehensive review. Advanced Composites and Hybrid Materials, 8 (3). https://doi.org/10.1007/s42114-025-01336-8
  43. Lv, X., Xiang, C., Zheng, Y., Zhou, W.-X., Lv, X.-L. (2024). Recent Developments in Using Microneedle Patch Technology as a More Efficient Drug Delivery System for Treating Skin Photoaging. Clinical, Cosmetic and Investigational Dermatology, 17, 2417–2426. https://doi.org/10.2147/ccid.s492774
  44. Lee, J. Y., Dong, S. H., Ng, K. W., Goh, C. F. (2025). Assessing the integrity and mechanical properties of commercial microneedles: innovation or fad? Drug Delivery and Translational Research, 15 (11), 3986–4003. https://doi.org/10.1007/s13346-025-01888-8
  45. Shu, W., Lijnse, T., McCartney, F., Brayden, D. J., Ní Annaidh, A., O’Cearbhaill, E. D. (2025). Computational and Experimental Analysis of Drug‐Coated Microneedle Skin Insertion: The Mode of Administration Matters. Advanced Materials Interfaces, 12 (17). https://doi.org/10.1002/admi.202500202
  46. AL-shaibani, A., Ghareeb, M. M. (2025). Fabrication and Ex-vivo Evaluation of Olanzapine Nanoparticles Based Dissolved Microneedle for Transdermal Delivery. Iraqi Journal of Pharmaceutical Sciences, 34 (2), 155–167. https://doi.org/10.31351/vol34iss2pp155-167
  47. Sikandar, M., Shoaib, M. H., Yousuf, R. I., Ahmed, F. R., Siddiqui, F., Saleem, M. T., Irshad, A. (2025). Dissolving microneedle patches for transdermal delivery of paroxetine: in-vitro, ex-vivo studies and its PBPK modeling. Therapeutic Delivery, 16 (9), 835–851. https://doi.org/10.1080/20415990.2025.2542721
  48. Harris, E. (2024). Microneedle Vaccine Patches Generated Immune Response in Children. JAMA, 331 (23), 1982. https://doi.org/10.1001/jama.2024.8629
  49. Leone, M., Mönkäre, J., Bouwstra, J. A., Kersten, G. (2017). Dissolving Microneedle Patches for Dermal Vaccination. Pharmaceutical Research, 34 (11), 2223–2240. https://doi.org/10.1007/s11095-017-2223-2
  50. Bhatnagar, S., Chawla, S. R., Kulkarni, O. P., Venuganti, V. V. K. (2017). Zein Microneedles for Transcutaneous Vaccine Delivery: Fabrication, Characterization, and in Vivo Evaluation Using Ovalbumin as the Model Antigen. ACS Omega, 2 (4), 1321–1332. https://doi.org/10.1021/acsomega.7b00343
  51. Yu, Y., Wang, J., Wu, M. X. (2023). Microneedle-Mediated Immunization Promotes Lung CD8+ T-Cell Immunity. Journal of Investigative Dermatology, 143 (10), 1983-1992.e3. https://doi.org/10.1016/j.jid.2023.03.1672
  52. Marshall, S., Sahm, L. J., Moore, A. C. (2016). The success of microneedle-mediated vaccine delivery into skin. Human Vaccines & Immunotherapeutics, 12 (11), 2975–2983. https://doi.org/10.1080/21645515.2016.1171440
  53. Ruan, S., Zhang, Y., Feng, N. (2021). Microneedle-mediated transdermal nanodelivery systems: a review. Biomaterials Science, 9 (24), 8065–8089. https://doi.org/10.1039/d1bm01249e
  54. Hulimane Shivaswamy, R., Binulal, P., Benoy, A., Lakshmiramanan, K., Bhaskar, N., Pandya, H. J. (2025). Microneedles as a Promising Technology for Disease Monitoring and Drug Delivery: A Review. ACS Materials Au, 5 (1), 115–140. https://doi.org/10.1021/acsmaterialsau.4c00125
  55. Wang, Z., Xiao, M., Li, Z., Wang, X., Li, F., Yang, H., Chen, Y., Zhu, Z. (2024). Microneedle Patches‐Integrated Transdermal Bioelectronics for Minimally Invasive Disease Theranostics. Advanced Healthcare Materials, 13 (17). https://doi.org/10.1002/adhm.202303921
  56. Jiang, X., Zeng, Y., Zhang, W., Wang, C., Li, W. (2023). Advances in microneedle patches for long-acting contraception. Acta Materia Medica, 2 (1). https://doi.org/10.15212/amm-2022-0042
  57. Arshad, M. S., Nazari, K., Rana, S. J., Zafar, S., Uzair, M., Ahmad, Z. (2023). Dissolving Microneedle Patches as Vaccine Delivery Platforms. British Journal of Pharmacy, 8(2). https://doi.org/10.5920/bjpharm.1334
  58. Shah, S. W. A., Li, X., Yuan, H., Shen, H., Pan, G., Xie, H., Shao, J. (2025). State‐of‐the‐Art Fabrication of Microneedle Patches: A Mini‐Review on Emerging Techniques. MedComm – Biomaterials and Applications, 4 (3). https://doi.org/10.1002/mba2.70020
  59. Pundir, G., Morris, S., Jakhmola, V., Parashar, T. P. (2024). Microneedle Transdermal Patches- A Novel Painless Approach with Improved Bioavailability for the Treatment of Diseases with Special Prevalence to Neonatal Infection. International Journal of Drug Delivery Technology, 14 (3), 1749–1757. https://doi.org/10.25258/ijddt.14.3.71
  60. Li, J., Zeng, M., Shan, H., Tong, C. (2017). Microneedle Patches as Drug and Vaccine Delivery Platform. Current Medicinal Chemistry, 24 (22). https://doi.org/10.2174/0929867324666170526124053
  61. Chauhan, S. S., Lobo, V. M., Borate, S. N., Jagade, S. S., Venuganti, V. V. K. (2022). Microneedle Array Patches for the Delivery of Therapeutic Agents. Smart Nanomaterials in Biomedical Applications. Cham: Springer, 223–267. https://doi.org/10.1007/978-3-030-84262-8_9
  62. Arangannan, S. (2025). Microneedle patches based on herbal formulations for biofilm disruption and management: a comprehensive review. TMP Universal Journal of Advances in Pharmaceutical Sciences, 1 (2). https://doi.org/10.69557/ac68y940
  63. Freundlich, E., Shimony, N., Gross, A., Mizrahi, B. (2023). Bioadhesive microneedle patches for tissue sealing. Bioengineering & Translational Medicine, 9 (3). https://doi.org/10.1002/btm2.10578
  64. Rabiee, N. (2025). Revolutionizing biosensing with wearable microneedle patches: innovations and applications. Journal of Materials Chemistry B, 13 (18), 5264–5289. https://doi.org/10.1039/d5tb00251f
  65. Yan, Y. (2025). Research progress of artificial intelligence-enabled microneedle technology in the treatment of myocardial infarction. Proceedings of the 4th International Conference on Biomedical and Intelligent Systems. New York: Association for Computing Machinery, 553–558. https://doi.org/10.1145/3745034.3745118
  66. Patil, G., Patil, C., Patil, H., Nikume, D., Kalal, A. (2025). A review on microneedle patches transdermal drug delivery system. International Journal of Advanced Research in Science, Communication and Technology, 5 (2), 382–397. https://doi.org/10.48175/ijarsct-23045
  67. Zhang, C. Y., Zhang, X., Zhao, X., Li, Y., Zhang, W., Chen, Y. et al. (2025). Dissolved Bubble Microneedle Patches for Co-Delivery of Hydrophobic and Hydrophilic Drugs to Improve Acne Vulgaris Therapy. https://doi.org/10.21203/rs.3.rs-7269052/v1
  68. Seema, M., Veeresh, T., Muthukumar, S. P. (2025). Boosting Curcumin Bioavailability: Unveiling the Potential of Sodium Caseinate Nanoparticle Microneedle Patches. Polymers for Advanced Technologies, 36 (8). https://doi.org/10.1002/pat.70279
  69. Lammerding, L. C., Breitkreutz, J. (2023). Technical evaluation of precisely manufacturing customized microneedle array patches via inkjet drug printing. International Journal of Pharmaceutics, 642, 123173. https://doi.org/10.1016/j.ijpharm.2023.123173
  70. Fahad, F., Ahn, M., Soo Kim, B. (2025). Advanced 3D-printed microneedle patches for smart drug delivery in wound care. International Journal of Bioprinting, 8514. https://doi.org/10.36922/ijb.8514
  71. Zhang, S., Wei, M., Luan, C., Gao, B. (2025). Bioinspired wearable polymer microneedle patches: pioneering diabetic wound therapy for the horizon. RSC Advances, 15 (39), 32509–32535. https://doi.org/10.1039/d5ra02557e
  72. Tabriz, A. G., Viegas, B., Okereke, M., Uddin, M. J., Lopez, E. A., Zand, N. et al. (2022). Evaluation of 3D Printability and Biocompatibility of Microfluidic Resin for Fabrication of Solid Microneedles. Micromachines, 13 (9), 1368. https://doi.org/10.3390/mi13091368
  73. Rajabi, M., Roxhed, N., Shafagh, R. Z., Haraldson, T., Fischer, A. C., Wijngaart, W. van der et al. (2016). Flexible and Stretchable Microneedle Patches with Integrated Rigid Stainless Steel Microneedles for Transdermal Biointerfacing. PLOS ONE, 11 (12), e0166330. https://doi.org/10.1371/journal.pone.0166330
  74. Su, Y., Shahriar, S. S. M., Andrabi, S. M., Wang, C., Sharma, N. S., Xiao, Y. et al. (2024). It Takes Two to Tangle: Microneedle Patches Co‐delivering Monoclonal Antibodies and Engineered Antimicrobial Peptides Effectively Eradicate Wound Biofilms. Macromolecular Bioscience, 24 (5). https://doi.org/10.1002/mabi.202300519
  75. Lin, X., Jia, Q., Lin, X., Shi, J., Gong, W., Shen, K. et al. (2025). Galvanic Cell Bipolar Microneedle Patches for Reversing Photoaging Wrinkles. Advanced Materials, 37 (16). https://doi.org/10.1002/adma.202500552
  76. Sun, L., Fan, L., Bian, F., Chen, G., Wang, Y., Zhao, Y. (2021). MXene-Integrated Microneedle Patches with Innate Molecule Encapsulation for Wound Healing. Research, 2021. https://doi.org/10.34133/2021/9838490
  77. Nadeem, A. Y., Ul Islam, M., Khan, S., Al-Suhaimi, E. A., Shehzad, A., Noor, A. (2025). Transdermal glucose responsive composite polymeric microneedle patches for personalized diabetes treatment: A novel approach to precision medicine. Journal of Drug Delivery Science and Technology, 111, 107161. https://doi.org/10.1016/j.jddst.2025.107161
  78. Arshad, M. S., Gulfam, S., Zafar, S., Jalil, N. A., Ahmad, N., Qutachi, O. et al. (2022). Engineering of tetanus toxoid-loaded polymeric microneedle patches. Drug Delivery and Translational Research, 13 (3), 852–861. https://doi.org/10.1007/s13346-022-01249-9
  79. Coates, I. A., Driskill, M. M., Rajesh, N. U., Lipkowitz, G., Ilyin, D., Xu, Y. et al. (2025). Free-Form Microfluidic Microneedle Array Patches. https://doi.org/10.1101/2025.02.03.635973
  80. Zeng, J., Lu, M., Wang, Y., Zhao, X., Zhao, Y. (2024). Photothermal Fish Gelatin‐Graphene Microneedle Patches for Chronic Wound Treatment. Small, 20 (48). https://doi.org/10.1002/smll.202405847
  81. Fan, L., Wang, Y., Wang, L., Lin, X., Wang, X., Shang, L. et al. (2025). Breathable core–shell microneedle patches for diabetic wound treatment. Materials Futures, 4 (2), 025402. https://doi.org/10.1088/2752-5724/adcbc6
  82. González García, L. E., MacGregor, M., Cavallaro, A., Koynov, K., Vasilev, K. (2022). Plasma polymer barrier layers to control the release kinetics from dissolvable microneedle patches. Plasma Processes and Polymers, 19 (12). https://doi.org/10.1002/ppap.202200099
  83. Jeong, J.-O., Lim, Y.-M., Lee, J. Y., Park, J.-S. (2023). Polyvinylpyrrolidone based graphene oxide hydrogels by radiation crosslinking for conductive microneedle patches. European Polymer Journal, 184, 111726. https://doi.org/10.1016/j.eurpolymj.2022.111726
  84. Gan, J., Sun, L., Tang, W., Zhao, Y., Bi, Y. (2025). Separable cryo-microneedle patches delivery with capsaicin integrated mesoporous dopamine for obesity treatment. Journal of Nanobiotechnology, 23 (1). https://doi.org/10.1186/s12951-025-03645-y
  85. Roy, S., Ghosh, B., Chandra, A., Das, D., Ghosh, P., Choudhury, S., Bose, A., Dinda, S. C. (2025). Enhanced bioavailability of lobeglitazone via dissolving microneedle patches in rats. International Journal of Applied Pharmaceutics, 17, 488–498. https://doi.org/10.22159/ijap.2025v17i5.54818
  86. Balghonaim, F. A., Chandru, K. K., Krishnegowda, M. B., Naveen, N. R., Goudanavar, P., Joshi, V. et al. (2025). Formulation and Evaluation of Bosentan Monohydrate-loaded Liposome-based Dissolving Microneedle Array Patches. Journal of Pharmacology and Pharmacotherapeutics, 17 (1), 37–52. https://doi.org/10.1177/0976500x251327444
  87. Arshad, M. S., Zafar, S., Zahra, A. T., Zaman, M. H., Akhtar, A., Kucuk, I. et al. (2020). Fabrication and characterisation of self-applicating heparin sodium microneedle patches. Journal of Drug Targeting, 29 (1), 60–68. https://doi.org/10.1080/1061186x.2020.1795180
  88. Fan, L., Wang, L., Wang, X., Li, M., Gu, H., Zhang, H. (2025). Multifunctional Silk and Gelatin Composed Microneedle Patches for Enhanced Wound Healing. Smart Medicine, 4 (1). https://doi.org/10.1002/smmd.137
  89. Su, Y., Andrabi, S. M., Shahriar, S. M. S., Wong, S. L., Wang, G., Xie, J. (2023). Triggered release of antimicrobial peptide from microneedle patches for treatment of wound biofilms. Journal of Controlled Release, 356, 131–141. https://doi.org/10.1016/j.jconrel.2023.02.030
  90. Ali, S., Ahmad, Z., Mahmood, A., Khan, M. I., Siddique, W., Latif, R. et al. (2025). Enhanced Transdermal Drug Delivery of Labetalol via Nanoparticle-Loaded Dissolvable Microneedle Patches. BioNanoScience, 15 (1). https://doi.org/10.1007/s12668-025-01799-5
  91. Hu, F., Gao, Q., Liu, J., Chen, W., Zheng, C., Bai, Q. et al. (2023). Smart microneedle patches for wound healing and management. Journal of Materials Chemistry B, 11 (13), 2830–2851. https://doi.org/10.1039/d2tb02596e
  92. Wang, X., Zhang, X., Zhao, Y., Zhan, X., Hu, C., Li, H. et al. (2025). Recombinant human collagen microneedle patches loaded with PRP for diabetic wound treatment. Journal of Materials Chemistry B, 13 (31), 9607–9624. https://doi.org/10.1039/d5tb00836k
  93. Avcil, M., Klokkers, J., Jeong, D., Celik, A. (2025). Efficacy of Dissolvable Microneedle Patches with Skincare Actives in Acne Management: A Monocentric Clinical Study. Biologics, 5 (2), 15. https://doi.org/10.3390/biologics5020015
  94. Ju, H. J., Kim, J. Y., Jeong, D. H., Lee, M.-S., Kim, G. M., Bae, J. M., Lee, J. H. (2025). Additional Use of Hyaluronic Acid-Based Dissolving Microneedle Patches to Treat Psoriatic Plaques: A Randomized Controlled Trial. Annals of Dermatology, 37 (2), 105. https://doi.org/10.5021/ad.24.024
  95. Babakurd, F. M., Azzawi, S. K., Alkhouli, M., Al-Nerabieah, Z. (2024). Evaluation of EMLA cream with microneedle patches in palatal anesthesia in children: a randomized controlled clinical trial. Scientific Reports, 14 (1). https://doi.org/10.1038/s41598-024-66212-9
  96. Ding, Y., Wang, J., Li, J., Cheng, Y., Zhou, S., Zhang, Y. et al. (2025). Tβ4‐Engineered ADSC Extracellular Vesicles Rescue Cell Senescence Through Separable Microneedle Patches for Diabetic Wound Healing. Advanced Science, 12 (26). https://doi.org/10.1002/advs.202505009
  97. Zheng, K., Zhou, T., Xiao, E., Wei, Q., Zhao, C. (2023). Human collagen decorating microneedle patches for transdermal therapy. Journal of Polymer Science, 62 (14), 3171–3182. https://doi.org/10.1002/pol.20230597
  98. La Malfa, F., van Hulst, I., Maaden, K., Ossendorp, F., Staufer, U. (2023). Evaluation of microneedle patches for improved intradermal delivery of molecularly-defined cancer vaccines. ResearchGate. https://doi.org/10.13140/RG.2.2.21124.50560
  99. Lee, M., Jeong, D., Yoon, K., Jin, J., Back, Y. W., Jang, I.-T. et al. (2025). Inactivated mycobacterium paragordonae delivered via microneedle patches as a novel tuberculosis booster vaccine. Human Vaccines & Immunotherapeutics, 21 (1). https://doi.org/10.1080/21645515.2025.2507473
Аналіз сучасного стану розроблення мікроголкових систем для трансдермальної доставки ліків (a scoping review)

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2026-02-28

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Боднар, Л. А., Ковальова, Т. М., Сидора, Н. В., Шмалько, О. О., Бердей, І. І., & Вишневська, Л. І. (2026). Аналіз сучасного стану розроблення мікроголкових систем для трансдермальної доставки ліків (a scoping review). ScienceRise: Pharmaceutical Science, (1 (59), 31–42. https://doi.org/10.15587/2519-4852.2026.352761

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№ 1 (59) (2026)

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Авторське право (c) 2026 Liubov Bodnar, Tetiana Kovalova, Natalia Sydora, Oleksandr Shmalko, Ihor Berdey, Liliia Vyshnevska

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