Systematic analysis of the theoretical arsenal of antihypertensive drugs in Ukraine
DOI:
https://doi.org/10.5281/zenodo.10838296Keywords:
arsenal of medicines, antihypertensive drugs, marketing analysis, standards of pharmacotherapy of arterial hypertension, anatomical, therapeutic and chemical classificationAbstract
Introduction. According to the World Heart Federation (WHF) and the World Health Organization (WHO), the number of patients with arterial hypertension (AH) aged 30-79 years has increased from 0.65 billion to 1.28 billion over the past 30 years. At the same time, about 50% of those diagnosed were unaware of the presence of a chronic disease and only 20% of patients had controlled hypertension, so about 17 million people die prematurely every year due to complications of cardiovascular disease. Materials and methods. The objects of the study were: international recommendations and guidelines on pharmacotherapy of hypertension, British National Formulary (BNF), 83rd edition, WHO Model List of Essential Medicines, State Register of Medicines (SRM) and State Formulary of Medicines of Ukraine (SFMU), 15th edition. Research methods: content analysis, comparative analysis and generalization of information. Results of the study. The analysis of international recommendations and guidelines revealed differences in the recommended treatment regimens for hypertension. In the comparative analysis of the AGEs registered in Ukraine in 2019 and in 2023, 1055 AGEs were analyzed in the 2019 State Register and 967 in the 2023 State Register, which in total include 562 single-, 352 two- and 53 three-component oral AGEs. It was found that during the five-year monitoring period, 109 imported and 109 domestic AGVs were included in the State List of Essential Medicines (taking into account the dose and manufacturer). However, there is a significant difference in the rates of exclusion of specialized medicines from the SMART: 227 imported and 14 domestically produced. The final stage of our study was a comparison of the theoretical arsenal of APIs with the arsenal of APIs available for purchase by outpatients in pharmacies (tabletki.ua was used as a model site) as of October 2023. It was found that of the imported APIs registered in Ukraine, only 48% are available for purchase by outpatients in pharmacies. For domestically manufactured AHLs, this figure is 81%. Conclusions. It has been established that differences in the recommended treatment regimens for hypertension in monitoring recommendations and guidelines have a significant impact on the formation of a rational pharmacotherapy process. The significant dynamics of the theoretical arsenal of AGEs in Ukraine over the past 5 years (2019-2023) has been recorded: an increase in the number of domestically produced AGEs in the DRLZ by 43%, and a decrease in the number of imported AGEs by 14%. The ratio between the number of imported and domestically manufactured AEDs available for booking (on the tabletki.ua website) is approximately 1:1.
Keywords: arsenal of medicines, antihypertensive drugs, marketing analysis, standards of pharmacotherapy of arterial hypertension, anatomical, therapeutic and chemical classification
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