Marketing research in terms of the prospects for creating a gel based on the phyto-substance Parmelia sulcata

Authors

DOI:

https://doi.org/10.5281/zenodo.17923308

Keywords:

пармелія борозенчаста, гель, фітосубстанції, опіки, ранозагоювальні препарати, маркетингові дослідження

Abstract

The aim of the study. To conduct marketing and analytical research of the pharmaceutical market of Ukraine to determine the assortment of domestic and imported drugs with burn-healing and wound-healing effects, as well as to evaluate the prospects for creating a new gel based on Parmelia sulcata liquid extract. Materials and Methods. Information-analytical, bibliosemantic, and marketing research methods were used. The data sources included the State Register of Medicinal Products of Ukraine, the Compendium reference book, and publications of domestic and foreign scientists. A comparative analysis of the range of medicinal products by dosage forms, active pharmaceutical ingredients, origin, and manufacturers was performed. Results. It was found that most burn-healing drugs are presented in soft dosage forms, particularly ointments (60.4%) and creams (26.4%), while gels account for only 5.6%. Medicines containing synthetic components prevail (over 70%), which leads to the risk of microbial resistance and allergic reactions. The share of herbal-based preparations does not exceed 25%. Parmelia sulcata raw material contains usnic acid, flavonoids, polysaccharides, and amino acids, which provide antimicrobial, anti-inflammatory, and reparative effects. The obtained results confirm the feasibility of developing a domestic hydrophilic gel containing Parmelia sulcata liquid extract as a promising agent for the treatment of burn injuries. Conclusions. It has been shown that the use of phytosubstances is an effective approach to improving the quality and safety of topical medicinal products. The creation of a gel based on Parmelia sulcata liquid extract has significant potential for the pharmacotherapy of burns and wounds under both military and civilian conditions.

References

World Health Organization. Burns [Internet]. Geneva: WHO; 2024 [cited 2025 Oct 25]. Available from: https://www.who.int/news-room/fact-sheets/detail/burns

Goh MC, et al. Advancing burn wound treatment: exploring hydrogel as a carrier—a review. Drug Deliv Transl Res. 2024;14:1150–1164. doi:10.1007/s13346-024-01455-7

Algül D, et al. Wound healing effects of new cream formulations with natural extracts: an experimental study. J Dermatol Sci. 2025;110(2):101–108. doi:10.1016/j.jdermsci.2025.101108

Chandika P, Noh H, Kim S. Enhanced wound-healing capability with inherent antimicrobial usnic-acid-containing scaffolds. Mater Today Bio. 2022;15:100328. doi:10.1016/j.mtbio.2022.100328

Maltezou HC, et al. Antimicrobial effectiveness of an usnic-acid-containing self-decontaminating coating. Int J Environ Res Public Health. 2022;19(22):15091. doi:10.3390/ijerph192215091

Munir M, et al. Assessment of the wound healing potential of a herbal gel formulation. J Ethnopharmacol. 2021;267:113541. doi:10.1016/j.jep.2020.113541

Khanna S, Singh G, Sharma S. Herbal formulations for wound healing: a review. J Ethnopharmacol. 2022;284:114757. doi:10.1016/j.jep.2021.114757

Lyggitsou G, et al. Wound healing potential of herbal hydrogel formulations: in vitro and in vivo evaluation. Polymers (Basel). 2024;16(11):2507. doi:10.3390/polym16112507

Alberts A, et al. Hydrogels for wound dressings: applications in burn care. Polymers (Basel). 2025;17(3):133. doi:10.3390/polym17030133

Hashemi SS, et al. Review on application of herbals and their polymer carriers for wound healing. J Herb Sci. 2024;14(1):45–59. doi:10.1016/j.herbsci.2024.45

Shukla AK, Tripathi S, Yadav S. Usnic acid: a promising bioactive agent for wound healing. J Nat Prod Res. 2022;36(4):511–520. doi:10.1080/14786419.2021.1908743

Ren M, Zhang Q, Zhao Y, et al. Discovery and excavation of lichen bioactive natural products. Nat Prod Rep. 2023;40(5):782–799. doi:10.1039/D2NP00090

Poulsen-Silva E, dos Santos A, Lima R. Bioactive lichen secondary metabolites and their applications. Metabolites. 2023;13(7):805. doi:10.3390/metabo1307080

Paździora W, Zielińska-Bliźniewska H, et al. Critical assessment of the anti-inflammatory potential of usnic acid and its derivatives: a review. Life (Basel). 2023;13(4):1046. doi:10.3390/life13041046

Poulsen-Silva E, et al. Gelatin-based membranes with usnic acid improve dermal burn healing. Int J Pharm. 2016;513(1–2):473–482. doi:10.1016/j.ijpharm.2016.09.033

Baczewska I, Kowalczyk J, Śliwińska-Bartkowiak M. Towards the use of lichens as a source of bioactive natural products. Front Pharmacol. 2024;15:1298476. doi:10.3389/fphar.2024.1298476

Wang H, Zhang Y, Li M, et al. Advances in research on bioactivity, toxicity, and metabolism of usnic acid. Front Pharmacol. 2022;13:963741. doi:10.3389/fphar.2022.963741

Usnea and Parmelia species as potential antimicrobial agents: a review. Phytomedicine Plus. 2023;3(4):100346. doi:10.1016/j.phyplu.2023.100346

Published

2025-12-14

How to Cite

Blahovisna, K., & Zuikina, S. (2025). Marketing research in terms of the prospects for creating a gel based on the phyto-substance Parmelia sulcata. Annals of Mechnikov’s Institute, (4), 72–88. https://doi.org/10.5281/zenodo.17923308

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Section

Research Articles