The study of the antimicrobial activity of 6-sulfonyl derivatives of 4-methyl-1,2- dihydroquinoline-2-one
Keywords:
1, 2-dihydroquinoline-2-one, sulfones, amides, antimicrobial activity, "structure - activity" relationship.Abstract
Experimental study of the antimicrobial activity of the nineteen new 6-R-sulfonyl derivatives of 4-methyl-1,2- dihydroquinolin-2-one has been carried out using the
wells method and the serial dilution method in liquid medium. The experiment has shown that 6-alkylsulfonyl- 4-methyl-1,2-dihydroquinoline-2-ones have weak activity but 4-methyl-2-oxo-1,2-dihydroquinolin-6-sulfonic acid amides exhibit pronounced antibacterial activity, especially against strains of S. aureus and E. coli. The important structural feature of 4-methyl-2-oxo-1,2- dihydroquinolin-6-sulfonic acid anilides that increases this activity is the presence of the substituent in the orthoposition of the benzene ring of the amide residue.
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