Development of the composition and technology of extemporaneous suppositories with сlindamycin and sea buckthorn oil

Автор(и)

  • V Chushenko National University of Pharmacy, Україна
  • T Yarnykh National University of Pharmacy,
  • T Osolodchenko Mechnikov Institute of Microbiology and Immunology,
  • G Yuryeva National University of Pharmacy, Україна
  • I Herasymova National University of Pharmacy, Україна

Ключові слова:

suppositories, technology, suppository base, clindamycin phosphate, sea buckthorn oil.

Анотація

Introduction. Antibacterial therapy certainly plays an important role in the treatment of these pathologies, although in most cases it causes allergic states, antibiotic resistance of various types of microorganism strains, and also a disfunction of normal vaginal biocoenosis. Anti-protozoal, antibacterial and antifungal agents are preferred, namely, ternidazole, metronidazole, fluconazole, clindamycin, miconazole, clotrimazole, nystatin, isoconazole etc. among the synthetic drugs used in gynecological practice. Prospective plant medicines for solving this problem are essential oils (tea tree, sea buckthorn, wormwood, chamomile), which provide inhibition of the development of pathogenic anaerobes. The aim of the work was to substantiate the composition and development of technology of combined vaginal suppositories (pessaries) with clindamycin phosphate and sea buckthorn oil for the treatment of infectious-inflammatory gynecological diseases. Materials and methods. Model samples of suppositories were prepared with 0.100 g of clindamycin phosphate and 0.500 g of sea buckthorn oil. Disperse system of suppositories with clindamycin and sea buckthorn oil is an emulsion of 1st type, therefore it is possible to use as emulsifiers the following substances: polysorbate-80, emulsion wax or alkaline soaps. Model samples of suppositories with clindamycin phosphate and sea buckthorn oil were checked by pharmaco-technological parameters (description, homogeneity, disintegration time, pH). The study of antibacterial properties of suppository model samples with clindamycin and sea buckthorn oil was carried out. Results and discussion. Samples of suppositories with polysorbate-80 become homogeneous and meet the requirements of the SPhU 2.0. The results of the conducted researches of pharmaco-technological parameters shown that model samples of suppositories with clindamycin phosphate and sea buckthorn oil meet the requirements of the SPhU 2.0 for the following parameters: description, homogeneity, disintegration time, pH. Conclusions. The composition and technology of suppositories with clindamycin phosphate and sea buckthorn oil for pharmacy preparation was developed. A technological instruction for the pharmacy preparation of suppositories has been developed and tested in the conditions of pharmacy.

Посилання

Podolskyi V.V. Modern possibilities of treating inflammatory diseases of the genital organs in women of childbearing age. V.V. Podolskyi, V.V. Podolskyi. Women's health. 2017. №5 (121). Р. 132-136.

Pharmacological research of Loravit suppositories. I.V. Herasymova, O.I. Tykhonov, O.S. Shpychak et al. Asian Journal of Pharmaceutics. 2018. N 12(1). P. 106-110.

Yarnykh T.G. Study of antibacterial activity of combined vaginal pessaries with fluconazole and amaranth oil / T.G. Yarnykh, Yu.V. Levachkova, V.М. Chushenko et al. Pharmaceutical Journal. 2016. № 2. P. 60-64.

A complete book on aromatherapy. Prevention and treatment of diseases by essential oils . S. S. Soldatchenko et al. .2nd ed., add. and recycled. Symferopol: Tavryda., 2007. 529 p.

Shapovalova N. V. Application of aromatherapy procedures for treatment of inflammatory processes of female genital organs .N. V. Shapovalova, A. P. Onishchuk, S. P. Ivaniuk. Pharmaceutical magazine. 2008. № 4. P. 53 56.

Yarnykh T.G. Study of the stability of the combined pessaries "Klimedeks" . T.G. Yarnykh, Yu.V. Levachkova, V.М. Chushenko et al. Pharmacy of Kazakhstan. 2013. № 6. P. 54-57.

The problem of scientific substantiation of technologies of extemporal formulation and ways of its solution. Message 2. Comparative analysis of modern pharmacopoeial requirements for technology and quality control of extemporaneous drugs. O. S. Soloviov et al. Pharmaceutical Journal . 2014. № 2. P. 3-12.

Burt S. Essential oils: their antibacterial properties and potential applications in foods – a review. S. Burt. Int. J. Food Microbiol. 2004. Vol. 94, Is. 6. P. 223–253.

Carson C. F. Melaleuca alternifolia (Tea Tree) oil: a review of anti-microbial and other medicinal properties. C. F. Carson, K. A. Hammer, T. V. Riley. Clin. Microbiol. Rev. 2006. Vol. 19, Is. 7. P. 50–62.

Melissa officinalis oil affects infectivity of enveloped herpesviruses. P. Chnitzler, A. Schuhmacher, A. Astani et al. Phytomedicine. 2008. Vol. 15, Is. 9. P. 734–740. 11. European Pharmacopoeia. 9th ed. Strasbourg: Council of Europe. 2017.

The United States Pharmacopoeia 40: The National Formulary 35. New York, 2017. 2569 p.

Governmental Pharmacopoeia of Ukraine: Suppositories and pessaries made in pharmacies . «Scientifical Pharmacopoeia center». – 2 App. – Kh. : RІRЕG, 2014. – P. 716-723.

##submission.downloads##

Як цитувати

Chushenko, V., Yarnykh, T., Osolodchenko, T., Yuryeva, G., & Herasymova, I. (2019). Development of the composition and technology of extemporaneous suppositories with сlindamycin and sea buckthorn oil. Анали Мечниковського Інституту, (2), 21–24. вилучено із https://journals.uran.ua/ami/article/view/185957

Номер

Розділ

Дослідні статті