Structures and biological activity of cuprophyllins

Анотація

Chlorophylls (a, b) are the porphyrin compounds and most common chemical in the plant’s world. In fact, these compounds are an obligatory intermediate product both in energy metabolism and in plant catabolism. At the same time, currently there are few pharmaceutical preparations on the pharmaceutical market based on chlorophylls. Dyes based on hydrolyzed chlorophyll are successfully used in the food industry. Commercial chlorophylline is a copper complex of hydrolyzed chlorophylls.  As shown earlier in TLC, the chlorophyllin mixture  contains a large number of different compounds.  It is like water-soluble saponified derivatives in the form of sodium-magnesium complexes, and similar structures in the form of a complex with copper. The latter are more brightly colored, soluble in water and widely used as coloring agents in cooking. In this case, if the initial chlorophyll was not found to have a pronounced biological activity, the substituted derivatives in the form of copper complexes possessed a number of new unique biological properties. Non-hydrolyzed hydrophobic cuprophylline obtained from eucalyptus leaves possessed high antimicrobial activity to most strains of staphylococci, inclusion resistant to antimicrobials and multiresistant strains.  This drug is called Chlorophyllipt, it is allowed to be used as a medicinal product and is one of the oldest  antibacterial drugs from plants on the market. It is marketed as ethanoic and oily solutions for topical use, and as an alcohol solution for intravenous injections. Its main purpose is the fight against staphylococcal infections.  Recently, found that the oral administration of chlorophyllipt activates cellular immunity and indirectly exhibits antiviral activity. Another compound of cuprophyllin is water-soluble chlorophyllin.  Some authors show the variability of the structure and biological activity of cuprophyllins. Different derivatives of chlorophyll have different biological activity.  Hydrophilic cuprophyllin chlorophyllin very good studied and have good profile of toxicity and uses in cooking as colorant. Chlorophyllin have such biological effects: antiatherosclerotic, antiviral, antimicrobial, immunomodulating, antimutagenic and anticancerogenic, antioxidant. Most of the studies were carried out as in vitro and in vivo with statistically trustworth results. Derivatives of chlorophyll are very perspective candidates for fight with multiresistant strains of  mnicroorganisms and viral infections. Derivatives of chlorophyll must be more studied for using as active pharmaceutical ingredients for development a new drugs in the form of injection, tablets, ointments.